Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs [PDF]
Nature Communications, 2017 Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular ...
Alexander C. Partin +5 more
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CCDC137/DGCR8 axis promotes aerobic glycolysis in hepatocellular carcinoma via activation of the AKT/mTOR signaling pathway [PDF]
European Journal of Medical ResearchIntroduction Hepatocellular carcinoma (HCC) is a leading cause of global cancer fatality. Understanding its molecular mechanisms is crucial for developing effective treatments.
Zhiying Xu +6 more
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Establishing a human embryonic stem cell clone with a heterozygous mutation in the DGCR8 gene
Stem Cell Research, 2021 DiGeorge Syndrome (DGS) Critical Region 8 (DGCR8) is a primary candidate gene in they DGS. The DGCR8 microprocessor complex subunit is an essential cofactor in the canonical miRNA biogenesis which is involved in diverse cellular functions such as cell ...
Dóra Reé +9 more
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Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis [PDF]
Molecular Biology of the Cell, 2021 We show that coilin, the Cajal body marker protein, impacts microRNA biogenesis in cell lines with or without Cajal bodies. We also show that coilin reduction decreases DGCR8 stability and phosphorylation at S377. Collectively, our results implicate coilin as a member of the regulatory network governing miRNA biogenesis.
Lett, Katheryn E. +3 more
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DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria
Life Science Alliance, 2021 Lack of miRNA biosynthesis in DGCR8-deficient macrophages did not block macrophage differentiation but caused overshooting type I IFN responses to mycobacterial glycolipids.
Barbara Killy +9 more
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The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response
Frontiers in Immunology, 2022 We have previously shown that the microRNA (miRNA) processor complex consisting of the RNAse Drosha and the DiGeorge Critical Region (DGCR) 8 protein is essential for B cell maturation. To determine whether miRNA processing is required to initiate T cell-
Patrick Daum +10 more
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Post-transcriptional control of DGCR8 expression by the Microprocessor [PDF]
RNA, 2009 The Microprocessor, comprising the RNase III Drosha and the double-stranded RNA binding protein DGCR8, is essential for microRNA (miRNA) biogenesis. In the miRNA processing pathway certain hairpin structures within primary miRNA (pri-miRNA) transcripts are specifically cleaved by the Microprocessor to release ∼60–70-nucleotide precursor miRNA (pre ...
Robinson, Triboulet +3 more
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Versatility of DGCR8 controls stem cell fate [PDF]
Cell Cycle, 2017 MicroRNAs (miRNA) are a class of small non-coding RNAs, which control the expression of protein coding genes via translational repression and/or mRNA degradation.
D. Cirera-Salinas, M. Bodak, C. Ciaudo
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Regulation of the MicroRNA Processor DGCR8 by the Tumor Suppressor ING1 [PDF]
Cancer Research, 2010 Abstract The ING family of tumor suppressor proteins controls several cellular functions relevant to antitumor protection, such as cell cycle control, apoptosis, senescence, or migration. ING proteins are functionally linked to the p53 pathway, and they participate in transcriptional control via the recognition of histone marks and ...
Gómez-Cabello, Daniel +5 more
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Expression levels of Drosha and Dicer enzymes and DGCR8 protein in pre-eclamptic patients [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2018 Introduction: Pre-eclampsia is a serious problem of pregnancy that is associated with proteinuria and increased blood pressure in the second half of pregnancy. It is one of the three leading causes of maternal and fetal mortality. Dysregulated expression
Roghayeh Dargahi +3 more
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