Results 31 to 40 of about 10,226 (209)

DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2

Journal of Biological Chemistry, 2021
Microprocessor complex, including DiGeorge syndrome critical region gene 8 (DGCR8) and DROSHA, recognizes and cleaves primary transcripts of microRNAs (pri-miRNAs) in the maturation of canonical miRNAs.
Masahiro Nogami, Yoshika Hayakawa-Yano, Atsushi Nakanishi   +2 more
exaly   +2 more sources

HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma. [PDF]

Oncol Rep
Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents and the current typical strategy remains unsatisfactory in clinical practice.
Ding SC, Shi CJ, Pang FX, Wen RJ, Li N, Mai YX, Zhou ST, Zhang JF.   +7 more
europepmc   +2 more sources

Peptidylarginine Deiminase 2 Regulates Expression of DGCR8 Affecting miRNA Biogenesis in Gonadotrope Cells

Reproduction, 2023
Canonical miRNA biogenesis requires DGCR8 microprocessor complex subunit, which helps cleave pri-miRNAs into pre-miRNAs. Previous studies found that inhibiting peptidylarginine deiminase (PAD) enzyme activity results in increased DGCR8 expression.
Brett A. Ralston, Lamia Khan, Stanley B. DeVore, Trent A Bronnenberg, Joseph W Flock, Ari O Sequoia, P. Thompson, Amy M. Navratil, Brian D. Cherrington   +8 more
semanticscholar   +2 more sources

Expression levels and polymorphisms of the microRNA maturing components; diagnostic values of Drosha, DGCR8 and Dicer in patients with vitiligo. [PDF]

Afr Health Sci
Background and Objective Even though the pathogenesis of vitiligo is still unclear, recent studies have suggested that miRNAs can contribute to the occurrence and progression of the disease.
Aşır S, İzci Ay Ö, Ertan Ay M, Çevik K, Özdemir GD, Türkegün Şengül M, Erdal ME, Türsen Ü.   +7 more
europepmc   +2 more sources

Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia [PDF]

BMC Medical Genetics, 2019
Background PE (preeclampsia) is a heterogeneous disorder with early onset PE (EOPE) and late onset PE (LOPE) subtypes. Associations between maternal miRNAs biosynthesis genes polymorphisms and risk of PE have been previously observed. However, the impact
Xin Huang, Zuodong Li, Jun Lei, Dapeng Wang, Yujing Zhang   +4 more
doaj   +3 more sources

Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules

Journal of Clinical Endocrinology and Metabolism
Background Mutations in micro-RNA (miRNA) regulators DICER1 and DGCR8 have recently been uncovered, revealing a potential novel mechanism driving thyroid tumor development.
Vincenzo Condello, Anello Marcello Poma, Elisabetta Macerola   +2 more
exaly   +2 more sources

The UGU-recognizing mechanism of DGCR8

, 2019
Human Microprocessor is a trimeric complex, composed of a RNase Ill - Drosha and the DGCR8 (DiGeorge syndrome chromosomal region 8) dimer, that processes primary microRNAs (pri-miRNAs) to initiate microRNA (miRNA) biogenesis.
Dang, Thi Lieu
core   +3 more sources

Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis [PDF]

Molecular Biology of the Cell, 2021
MicroRNAs (miRNAs) are ∼22 nt small noncoding RNAs that control gene expression at the posttranscriptional level through translational inhibition and destabilization of their target mRNAs.
Katheryn E. Lett, Madelyn K. Logan, Douglas M McLaurin, M. Hebert   +3 more
semanticscholar   +3 more sources

Disrupted miRNA Biogenesis Machinery Reveals Common Molecular Pathways and Diagnostic Potential in MDS and AML [PDF]

Biomedicines
Background: Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal stem cell disorders in which disrupted post-transcriptional regulation contributes to aberrant hematopoiesis and leukemic transformation.
Kenan Çevik, Mustafa Ertan Ay, Anıl Tombak, Özlem İzci Ay, Ümit Karakaş, Mehmet Emin Erdal   +5 more
doaj   +2 more sources

Primary MicroRNA Processing Assay Reconstituted Using Recombinant Drosha and DGCR8 [PDF]

, 2013
In animals, the Microprocessor complex cleaves primary transcripts of microRNAs (pri-miRNAs) to produce precursor microRNAs in the nucleus. The core components of Microprocessor include the Drosha ribonuclease and its RNA-binding partner protein DiGeorge
Ian Barr, Barr, Ian, Barr, I, Guo, F, Guo, Feng, Feng Guo   +5 more
core   +8 more sources