Results 61 to 70 of about 9,673 (191)

DiGeorge Critical Region 8 (DGCR8) Is a Double-cysteine-ligated Heme Protein [PDF]

, 2011
All known heme-thiolate proteins ligate the heme iron using one cysteine side chain. We previously found that DiGeorge Critical Region 8 (DGCR8), an essential microRNA processing factor, associates with heme of unknown redox state when overexpressed in ...
Ian Barr, Brooke D. Scheidemantle, Barr, Ian, Rachel Senturia, Smith, Aaron T, Yanqiu Chen, Feng Guo, Scheidemantle, Brooke D, Judith N. Burstyn, Aaron T. Smith, Chen, Yanqiu, Senturia, Rachel, Burstyn, Judith N, Guo, Feng   +13 more
core   +1 more source

Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma

Cells
MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays
Lia Rodrigues, Arnaud Da Cruz Paula, Paula Soares, João Vinagre   +3 more
openaire   +4 more sources

Unmasking the Influence of Viral Micro‐RNAs on Host Immunity

Immunology &Cell Biology, Volume 104, Issue 10, Page 964-974, November‐December 2026.
Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton, Bernadette M. Saunders   +1 more
wiley   +1 more source

Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Understanding the neuronal functions of diverse RNA pathways will lead to treatments of human neurological diseases that are caused by perturbations in RNA metabolism. Two proteins, Drosha and Pasha/DGCR8, play important roles in neurons, where they are responsible for the biogenesis of many microRNAs.
Arthur, Luhur, Geetanjali, Chawla, Yen-Chi, Wu, Jing, Li, Nicholas S, Sokol   +4 more
openaire   +2 more sources

DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. [PDF]

PLoS ONE, 2013
Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease.
Lukas T Jeker, Xuyu Zhou, Robert Blelloch, Jeffrey A Bluestone   +3 more
doaj   +1 more source

Interplay Between Epigenetics and Reactive Oxygen Species in Tumor Radioresistance: Mechanisms and Therapeutic Strategies for Radiotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Radiotherapy efficacy is constrained by tumor radioresistance, which arises in part from the interplay between reactive oxygen species (ROS) and epigenetic regulation. This review systematically synthesizes the bidirectional “epigenetics‐ROS interactive network” that governs tumor radiosensitivity. We propose that this network operates through
Zhengmao Yang, Jiaxin Wang, Guofang Wang, Jiamin Zhu, Shengnan Zhang, Wenjian Guo   +5 more
wiley   +1 more source

DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures

, 2010
DiGeorge critical region 8 (DGCR8) is essential for maturation of microRNAs (miRNAs) in animals. In the cleavage of primary transcripts of miRNAs (pri-miRNAs) by the Drosha nuclease, the DGCR8 protein directly binds and recognizes pri-miRNAs through a ...
Z. Hong Zhou, Rachel Senturia, Michael Faller, Michio Matsunaga, Daniel Toso, Yanqiu Chen, Ivo Atanasov, Feng Guo   +7 more
core   +1 more source

DGCR8 acts as an adaptor for the exosome complex to degrade double-stranded structured RNAs [PDF]

, 2015
The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA (snoRNA)
Cáceres, Javier F., Cordiner, Ross, Macias, Sara, Plass, Mireya, Cordiner, Ross A., Gautier, Phillipe, Macias Ribela, Sara, Gautier, Philippe   +7 more
core   +1 more source

Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells

, 2023
In brief: DGCR8 microprocessor complex, which is important for miRNA biogenesis, is regulated by peptidylarginine deiminase 2 and expression fluctuates in gonadotrope cells across the mouse estrous cycle.
DeVore, Stanley B, Cherrington, Brian D, Ralston, Brett A, Thompson, Paul R, Flock, Joseph W, Sequoia, Ari O, Navratil, Amy M, Khan, Lamia, Bronnenberg, Trent A   +8 more
core   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source