Results 61 to 70 of about 10,226 (209)

WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complex

Life Science Alliance, 2021
WBP2 protein blocks the microRNA biogenesis via physical interactions with the microprocessor complex, and reverts the tumor-suppressive role of DGCR8.
Hossein Tabatabaeian, Shen Kiat Lim, Tinghine Chu, Sock Hong Seah, Yoon Pin Lim   +4 more
doaj   +1 more source

Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures [PDF]

Biophysical Journal, 2020
Although conformational dynamics of RNA molecules are potentially important in microRNA (miRNA) processing, the role of the protein binding partners in facilitating the requisite structural changes is not well understood. In previous work, we and others have demonstrated that nonduplex structural elements and the conformational flexibility they support
Suzette A. Pabit, Yen-Lin Chen, Emery T. Usher, Erik C. Cook, Lois Pollack, Scott A. Showalter   +5 more
openaire   +2 more sources

Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells

Stem Cell Reports, 2017
Summary: Pluripotent stem cells (PSCs) deficient for microRNAs (miRNAs), such as Dgcr8−/− or Dicer−/– embryonic stem cells (ESCs), contain no mature miRNA and cannot differentiate into somatic cells.
Zhong Liu, Cheng Zhang, Maria Skamagki, Alireza Khodadadi-Jamayran, Wei Zhang, Dexin Kong, Chia-Wei Chang, Jingyang Feng, Xiaosi Han, Tim M. Townes, Hu Li, Kitai Kim, Rui Zhao   +12 more
doaj   +1 more source

Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells

Redox Biology, 2020
The use of human mesenchymal stem cells (hMSCs) in clinical applications requires large-scale cell expansion prior to administration. However, the prolonged culture of hMSCs results in cellular senescence, impairing their proliferation and therapeutic ...
Yi-deun Jung, Seul-Ki Park, Dayeon Kang, Supyong Hwang, Myoung-Hee Kang, Seung-Woo Hong, Jai-Hee Moon, Jae-Sik Shin, Dong-Hoon Jin, Dalsan You, Joo-Yong Lee, Yun-Yong Park, Jung Jin Hwang, Choung Soo Kim, Nayoung Suh   +14 more
doaj   +1 more source

Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation

Scientific Reports, 2018
DiGeorge syndrome chromosomal region 8 (DGCR8), a double-stranded-RNA-binding protein, participates in the miRNA biogenesis pathway and contributes to miRNA maturation by interacting with the RNAase III enzyme Drosha in cell nuclei.
Yanan Zou, Zixuan Chen, Brett L. Jennings, Guannan Zhao, Qingqing Gu, Anindya Bhattacharya, Yan Cui, Bo Yu, Kafait U. Malik, Junming Yue   +9 more
doaj   +1 more source

Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8

Journal of Clinical Endocrinology and Metabolism, 2021
Background The genomic and transcriptomic landscape of widely invasive follicular thyroid carcinomas (wiFTCs) and Hürthle cell carcinoma (HCC) are poorly characterized, and subsets of these tumors lack information on genetic driver events.
Johan O Paulsson, N. Rafati, Sebastian DiLorenzo, Yi Chen, F. Haglund, J. Zedenius, C. Juhlin   +6 more
semanticscholar   +1 more source

The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.

General Physiology and Biophysics, 2022
Study was focused on regulatory interactions between the circadian system and the renin-angiotensin system in control of microRNA (miRNA) biosynthesis. Responsiveness of the miRNA biosynthetic pathway, selected pre-miRNAs and clock genes to angiotensin ...
Paulína Pidíková, B. Chovancová, B. Mravec, I. Herichová   +3 more
semanticscholar   +1 more source

Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

Neural Development, 2011
Background Neuronal phenotypes associated with hemizygosity of individual genes within the 22q11.2 deletion syndrome locus hold potential towards understanding the pathogenesis of schizophrenia and autism.
Barker Alison J, Hsu Ruby, Schofield Claude M, Gertz Caitlyn C, Blelloch Robert, Ullian Erik M   +5 more
doaj   +1 more source

Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8

Aging, 2020
Methyltransferase-like protein 3 (METTL3) regulates multiple cell functions and diseases by modulating N6-methyladenosine (m6A) modifications. However, it is still unclear whether METTL3 involves in the pathogenesis of diabetic retinopathy (DR).
Xu Zha, Xiao-ting Xi, Xinyu Fan, Minjun Ma, Yuanping Zhang, Yanni Yang   +5 more
semanticscholar   +1 more source

DGCR8 expression levels.

, 2014
a) box plots showing a decreased DGCR8 mRNA levels in subjects with 22q11DS compared to TD and b) DGCR8 protein expression levels measured by Western blot analysis shows a significant decrease in 22q11DS individuals when compared to TD controls.
Blythe Durbin-Johnson (185037), Nicolas Charlet-Berguerand (607232), Tony J. Simon (607234), Flora Tassone (207299), Ravi Dandekar (607231), Vicki J. Hwang (607230), Chantal Sellier (607229), Frank R. Sharp (430097), Kathleen Angkustsiri (607233), Bradley P. Ander (430096)   +9 more
core   +1 more source