Results 81 to 90 of about 9,673 (191)
Journal of Experimental & Clinical Cancer Research, 2023 Background RNA binding proteins (RBPs)—regulated gene expression play a vital role in various pathological processes, including the progression of cancer. However, the role of RBP in hepatocellular carcinoma (HCC) remains much unknown.
Shuang Tao +8 more
doaj +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
Cell Proliferation, Volume 59, Issue 9, September 2026.m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
Understanding Recognition of Primary MicroRNAs by Human Drosha/DGCR8
, 2020 MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by suppressing messenger RNAs. The RNase Drosha, as part of the Microprocessor complex, performs the initial processing step in miRNA biogenesis.
Partin, Alexander Christian
core +1 more source
Cell Reports, 2013 Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder caused by the expansion of 55–200 CGG repeats in the 5′ UTR of FMR1.
Chantal Sellier +15 more
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Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. [PDF]
PLoS ONE, 2012 Small RNAs such as microRNAs play important roles in embryonic stem cell maintenance and differentiation. A broad range of microRNAs is expressed in embryonic stem cells while only a fraction of their targets have been identified. We have performed large-
Matthew P A Davis +10 more
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MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights
Brain and Behavior, Volume 16, Issue 8, August 2026.MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi +3 more
wiley +1 more source
Correction to: Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo [PDF]
Cellular and Molecular Life Sciences, 2019 The section: "miRNA‑independent functions of DICER" was missed between the section "miRNA‑independent functions of DROSHA and DGCR8" and the section "The Dgcr8 knockout strategy to study miRNA functions" in the original publications.
Wen-Ting Guo, Yangming Wang
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 5, Page 331-337, July 2026.ABSTRACT Chromosome 22q11.2 deletion is the greatest single genetic factor predisposing to schizophrenia. The prevalence of schizophrenia reported ranges from 2% to 30% in patients with chromosome 22q11.2 deletion syndrome with a still discussed phenotype.
Micha Gawlik +3 more
wiley +1 more source
Regulation of HBEGF by Micro-RNA for Survival of Developing Human Trophoblast Cells. [PDF]
PLoS ONE, 2016 The growth factor HBEGF is upregulated post-transcriptionally in the low O2 environment of the human placenta during the first 10 weeks of pregnancy. We have examined the possible roles of HBEGF turnover and micro-RNA (miRNA) in its regulation by O2 in ...
Chandni V Jain +6 more
doaj +1 more source
Infectious Agents and Cancer, 2021 Background Head and neck squamous cell carcinoma (HNSCC) is the 6th most common malignant cancer type worldwide. Radiosensitivity has been shown to be significantly increased in patients with human papillomavirus (HPV)-positive HNSCC compared with HPV ...
Dan Long +6 more
doaj +1 more source