Results 81 to 90 of about 10,226 (209)

miRNA Sensor HuR Compartmentalizes Ago2‐Uncoupled miRNAs to Lipid Droplets to Buffer miRNA Activity in Mammalian Cells

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
This study revealed a dose‐dependent miRNA buffering mechanism involving extracellular export and storage of miRNA on lipid droplets. The protein HuR facilitates miRNA buffering by dissociating miRNAs from Ago2 and promoting miRNA accumulation on lipid droplets or its extracellular export, depending on cellular requirements.
Sreemoyee Chakraborty, Diptankar Bandyopadhyay, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +3 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

DGCR8 acts as an adaptor for the exosome complex to degrade double-stranded structured RNAs [PDF]

, 2015
The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA (snoRNA)
Cáceres, Javier F., Cordiner, Ross, Macias, Sara, Plass, Mireya, Cordiner, Ross A., Gautier, Phillipe, Macias Ribela, Sara, Gautier, Philippe   +7 more
core   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

DGCR8 microprocessor subunit mutation and expression deregulation in thyroid lesions [PDF]

, 2023
Deregulation of microRNA (miRNA) processing is a driver event in several tumours including thyroid cancer. DiGeorge Critical Region 8 (DGCR8) gene holds a critical role in miRNA biogenesis, as a microprocessor complex component, and in the development of
Rodrigues, Lia, Vinagre, João, Canberk, Sule, Macedo, Sofia, Soares, Paula   +4 more
core  

Mutationen des DROSHA/DGCR8 Mikroprozessor-Komplexes in blastemreichen Hochrisiko-Wilms Tumoren

, 2022
Wilms tumor (WT) or nephroblastoma is the most common kidney tumor in childhood. Several genetic alterations have been identified in WT over the past years. However, a clear-cut underlying genetic defect has remained elusive.
Vardapour, Romina
core   +1 more source

Human multi‐tissue transcriptomics identifies galectin‐1 and follistatin‐like 1 as exerkines with distinct transcript‐to‐serum coupling after exercise

The Journal of Physiology, Volume 604, Issue 12, Page 4815-4833, 15 June 2026.
Abstract figure legend Acute aerobic exercise induces LGALS1, FSTL1, OGN and C1QTNF3 in both skeletal muscle and adipose tissue, with LGALS1 and FSTL1 upregulation corresponding to increased circulating galectin‐1 and follistain‐like 1. Red and yellow brick bars represent the contribution of skeletal muscle and adipose tissue, respectively, integrating
Jaeseung Song, Eun‐Suk Cho, Yu Rim Kwon, Jong Suk Park, Ji Sun Nam, YuSik Kim   +5 more
wiley   +1 more source

CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-α/NF-κB signaling

Cell Death and Disease, 2022
Glioma stem cells (GSCs) are a special kind of cells in GBM showing tumor initiation, self-renewal, and multi-lineage differentiation abilities. Finding novel circRNAs related to GSCs is of great significance for the study of glioma.
Yang Jiang, Junshuang Zhao, Yingliang Liu, Juntao Hu, Liang Gao, Hui Wang, Daming Cui   +6 more
doaj   +1 more source

Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing

, 2006
DGCR8/Pasha is an essential cofactor for Drosha, a nuclear RNase III that cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) in eukaryotes.
Suh, Mi Ra, Kim, V. Narry, Han, Jinju, Yeom, Kyu-Hyeon, Lee, Yoontae   +4 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, Volume 16, Issue 5, Page 921-931, May 2026.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source