Results 91 to 100 of about 10,226 (209)

Select amino acids in DGCR8 are essential for the UGU-pri-miRNA interaction and processing

, 2020
Microprocessor, composed of DROSHA and DGCR8, processes primary microRNAs (pri-miRNAs) in miRNA biogenesis. Its cleavage efficiency and accuracy are enhanced because DGCR8 interacts with the apical UGU motif of pri-miRNAs.
Li, Shaohua, Dang, Thi Lieu, Le, Cong Truc, Bao, Sheng, Nguyen, Trung Duc, Le, Minh Ngoc, Nguyen, Thuy Linh, Nguyen, Tuan Anh   +7 more
core   +1 more source

How Epigenetics Bridges Genes and Environment: A Multiomics Evidence Chain in Congenital Diaphragmatic Hernia

Birth Defects Research, Volume 118, Issue 5, May 2026.
ABSTRACT Background/Objectives Congenital diaphragmatic hernia (CDH) is a severe developmental anomaly with high etiological heterogeneity. Although numerous susceptibility genes have been identified, genetic factors alone fail to explain the full disease risk. Epidemiological data highlight the contribution of environmental exposures.
Yunshan Gao, Xian Zhu, Rutao Dai, Xichen Zhang, Yongyu Ma, Ya Dao, Junru Chen, Shiwu Yang, Jun Wu   +8 more
wiley   +1 more source

Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. [PDF]

PLoS ONE, 2012
Small RNAs such as microRNAs play important roles in embryonic stem cell maintenance and differentiation. A broad range of microRNAs is expressed in embryonic stem cells while only a fraction of their targets have been identified. We have performed large-
Matthew P A Davis, Cei Abreu-Goodger, Stijn van Dongen, Dong Lu, Peri H Tate, Nenad Bartonicek, Claudia Kutter, Pentao Liu, William C Skarnes, Anton J Enright, Ian Dunham   +10 more
doaj   +1 more source

MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

Brain and Behavior, Volume 16, Issue 5, May 2026.
Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah, Pareshkumar N. Patel, Omayma Salim Waleed, Jamuna K. V., Vandana Tripathi, L. Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra   +7 more
wiley   +1 more source

Understanding Recognition of Primary MicroRNAs by Human Drosha/DGCR8

, 2022
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by suppressing messenger RNAs. The RNase Drosha, as part of the Microprocessor complex, performs the initial processing step in miRNA biogenesis.
Partin, Alexander Christian
core  

The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition

Endocrine Regulations, 2018
Objectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the
Soufi Farhad Ghadiri, Zonouzi Ali Akbar Poursadegh, Eftekhar Ebrahim, Kamali Kamila, Chegeni Sara Aghakhani, Zonouzi Ahmad Poursadegh   +5 more
doaj   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Sequestration of DROSHA and DGCR8 by Expanded CGG RNA Repeats Alters MicroRNA Processing in Fragile X-Associated Tremor/Ataxia Syndrome

Cell Reports, 2013
Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder caused by the expansion of 55–200 CGG repeats in the 5′ UTR of FMR1.
Chantal Sellier, Fernande Freyermuth, Ricardos Tabet, Tuan Tran, Fang He, Frank Ruffenach, Violaine Alunni, Herve Moine, Christelle Thibault, Adeline Page, Flora Tassone, Rob Willemsen, Matthew D. Disney, Paul J. Hagerman, Peter K. Todd, Nicolas Charlet-Berguerand   +15 more
doaj   +1 more source

HPV16 E6 enhances the radiosensitivity in HPV-positive human head and neck squamous cell carcinoma by regulating the miR-27a-3p/SMG1 axis

Infectious Agents and Cancer, 2021
Background Head and neck squamous cell carcinoma (HNSCC) is the 6th most common malignant cancer type worldwide. Radiosensitivity has been shown to be significantly increased in patients with human papillomavirus (HPV)-positive HNSCC compared with HPV ...
Dan Long, Li Xu, Zeyi Deng, Dandan Guo, Yangchun Zhang, Zhaohui Liu, Chunlin Zhang   +6 more
doaj   +1 more source

Systemic microRNA profiles associated with coronary plaque stability and clinical phenotypes in patients with coronary artery disease

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
This study identifies circulating microRNAs associated with plaque destabilization in cardiovascular disease, highlighting their potential as non‐invasive biomarkers and therapeutic targets. Abstract Background The development of coronary artery disease (CAD) and plaque destabilization are caused by endothelial dysfunction, inflammation and hypoxia ...
Souhir Wassaifi, Nadia Rahali, Josef Finsterer, Dhaker Lahidheb, Bertrand Kaeffer, Sinda Zarrouk   +5 more
wiley   +1 more source