Results 91 to 100 of about 9,673 (191)
Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs
WIREs RNA, Volume 17, Issue 4, July/August 2026.NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind +2 more
wiley +1 more source
PLoS ONE, 2016 Severe radiation-induced toxicities limit treatment efficacy and compromise outcomes of lung cancer. We aimed to identify microRNA-related genetic variations as biomarkers for the prediction of radiotherapy-induced acute toxicities. We genotyped 233 SNPs
Rong Li +8 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.This study revealed a dose‐dependent miRNA buffering mechanism involving extracellular export and storage of miRNA on lipid droplets. The protein HuR facilitates miRNA buffering by dissociating miRNAs from Ago2 and promoting miRNA accumulation on lipid droplets or its extracellular export, depending on cellular requirements.
Sreemoyee Chakraborty +3 more
wiley +1 more source
Expression levels of microRNA machinery components Drosha, Dicer and DGCR8 in human (AGS, HepG2, and KEYSE-30) cancer cell lines [PDF]
: MicroRNAs (miRNAs) have recently been shown to play fundamental roles in diverse cellular processes and linked to variety of cancers. Dicer and Drosha are tw major enzymes in the miRNA maturation process.
حسینی اصل, سید سعید +7 more
core
DGCR8 Phosphorylation is Required for the Repair of UV-induced DNA Lesions Independently of MicroRNA Processing [PDF]
, 2015 Thesis (Ph.D.)--University of Washington, 2015Ultraviolet (UV) radiation generates toxic and mutagenic DNA lesions such as cyclobutane pyrimidine dimers (CPDs) and 6-4 pyrimidine-pyrimidone photoproducts (6-4PPs) and is a carcinogen.
Calses, Philamer
core
Circ PSMC3 inhibits prostate cancer cell proliferation by downregulating DGCR8.
European review for medical and pharmacological sciences, 2020 The importance of circular RNAs in malignant tumors has attracted a lot of attention. Circular PSMC3 (CircPSMC3) is identified as a tumor suppressor in gastric cancer. The role of circPSMC3 in prostate cancer (PCa) remains unclear. Our study aims to uncover whether and how circPSMC3 functions in PCa development.Real Time-quantitative Polymerase Chain ...
Dong, J.-S., Wu, B., Chen, X.-H.
openaire +2 more sources
Protein & Cell, 2018 Primitive mammalian heart transforms from a single tube to a four-chambered muscular organ during a short developmental window. We found that knocking out global microRNA by deleting Dgcr8 microprocessor in Mesp1 cardiovascular progenitor cells lead to ...
Xi Chen +10 more
doaj +1 more source
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, Volume 2, Issue 2, June 2026.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk
Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin +2 more
wiley +1 more source
, 2023 Additional file 8: Supplementary Figure S7. Immunofluorescence microscopy of V5 and DGCR8 in CCDC137-V5 and DGCR8-overexpressing HCCLM3, JHH-7 and PLC/PRF/5 cells.
Shuang Tao (11510260) +8 more
core +1 more source