Results 111 to 120 of about 10,226 (209)

Meiotic defects in GC-Dcr1 and GC-Dgcr8 mutant testes.

, 2014
(A–D) Anti-γH2AX (green), present in the entire nucleus in early meiotic stages and located to the XY body during the pachytene stage, indicates a decreased number of tubules containing XY body positive cells in GC-Dcr1 and GC-Dgcr8 mutant testes ...
Noora Kotaja (202349), Christelle Borel (138807), Adem Bilican (632631), Henrik Kaessmann (11329), Céline Zimmermann (558274), Maria Warnefors (325838), Lee B. Smith (161960), Yannick Romero (105364), Serge Nef (45552)   +8 more
core   +1 more source

Circ PSMC3 inhibits prostate cancer cell proliferation by downregulating DGCR8.

European review for medical and pharmacological sciences, 2020
The importance of circular RNAs in malignant tumors has attracted a lot of attention. Circular PSMC3 (CircPSMC3) is identified as a tumor suppressor in gastric cancer. The role of circPSMC3 in prostate cancer (PCa) remains unclear. Our study aims to uncover whether and how circPSMC3 functions in PCa development.Real Time-quantitative Polymerase Chain ...
Dong, J.-S., Wu, B., Chen, X.-H.
openaire   +2 more sources

SUMOylation at K⁷⁰⁷of DGCR8 controls direct function of primary microRNA [PDF]

Nucleic Acids Research, 2015
DGCR8 (DiGeorge syndrome critical region gene 8) is essential for primary microRNA (pri-miRNA) processing in the cell nucleus. It specifically combines with Drosha, a nuclear RNase III enzyme, to form the Microprocessor complex (MC) that cleaves pri-miRNA to precursor miRNA (pre-miRNA), which is further processed to mature miRNA by Dicer, a cytoplasmic
Zhu, Changhong, Chen, Cheng, Huang, Jian, Zhang, Hailong, Zhao, Xian, Deng, Rong, Dou, Jinzhuo, Jin, Hui, Chen, Ran, Xu, Ming, Chen, Qin, Wang, Yanli, Yu, Jianxiu   +12 more
openaire   +2 more sources

DNA Methylation Episignature as a Novel Diagnostic Tool for Diamond‐Blackfan Anemia Syndrome

American Journal of Hematology, Volume 101, Issue 2, Page 228-241, February 2026.
Diamond‐Blackfan Anemia Syndrome (DBAS) is a congenital bone marrow failure disorder characterized by defective erythropoiesis and a spectrum of congenital anomalies, including craniofacial malformations, limb abnormalities, and cardiac and renal defects.
Paola Quarello, Karim Karimi, Slavica Trajkova, Emanuela Garelli, Mehdi Samadieh, Emanuela Iovino, Tommaso Pippucci, Giovanni Papagni, Sandra Dalfonso, Lucia Corrado, Serena Rizzo, Adriana Carando, Jennifer Kerkhof, Jessica Rzasa, Haley McConkey, Michael Levy, Marco Zecca, Francesca Fioredda, Angelica Barone, Simone Cesaro, Maria Gabelli, Francesca Torchio, Giulia Zucchetti, Maria Elena Cantarini, Paola Corti, Ugo Ramenghi, Franco Locatelli, Franca Fagioli, Bekim Sadikovic, Alfredo Brusco   +29 more
wiley   +1 more source

Expression levels of microRNA machinery components Drosha, Dicer and DGCR8 in human (AGS, HepG2, and KEYSE-30) cancer cell lines [PDF]

: MicroRNAs (miRNAs) have recently been shown to play fundamental roles in diverse cellular processes and linked to variety of cancers. Dicer and Drosha are tw major enzymes in the miRNA maturation process.
حسینی اصل, سید سعید, جعفری, ناصر, ایانگ, گلن, شیرزاد, زهره, پیری دوگاهه, هادی, علی بیکی, فاطمه, زرگر, سید جلال, بهلولی, شهاب   +7 more
core  

Knockdown of DGCR8 using DsiRNA.

, 2014
(A) Relative expression of DGCR8 gene measured by qPCR verifying knockdown. (n = 3, **** = p values of
Yan Long Edmund Lui (601898), Louise Marie Hafner (601900), Kian Hwa Tan (366805), Tuan Lin Tan (57411), Wee Hong Woo (601899), Eng Lee Tan (167237), Peter Timms (206543)   +6 more
core   +1 more source

Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance

Nature Communications, 2020
In response to DNA double-strand breaks (DSBs), repair proteins are recruited to the damaged sites. Ubiquitin signaling plays a critical role in coordinating protein recruitment during the DNA damage response.
Qinglei Hang, Liyong Zeng, Li Wang, Litong Nie, Fan Yao, Hongqi Teng, Yalan Deng, Shannon Yap, Yutong Sun, S. Frank, Junjie Chen, Li Ma   +11 more
semanticscholar   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

DiGeorge Critical Region 8 (DGCR8) Is a Double-cysteine-ligated Heme Protein

, 2011
All known heme-thiolate proteins ligate the heme iron using one cysteine side chain. We previously found that DiGeorge Critical Region 8 (DGCR8), an essential microRNA processing factor, associates with heme of unknown redox state when overexpressed in ...
Ian Barr, Brooke D. Scheidemantle, Barr, Ian, Rachel Senturia, Smith, Aaron T, Yanqiu Chen, Feng Guo, Scheidemantle, Brooke D, Judith N. Burstyn, Aaron T. Smith, Chen, Yanqiu, Senturia, Rachel, Burstyn, Judith N, Guo, Feng   +13 more
core   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source