Results 111 to 120 of about 9,673 (191)

Sylamer plots of miRNA seed enrichment amongst genes whose expression changes following Dgcr8 depletion.

, 2012
A) Heterozygote vs. Dgcr8-depleted cells. Independent homozygous mutant and heterozygous cell lines are considered replicates. Array probes and associated transcripts were sorted according to log fold change in Dgcr8gt1/tm1 and Dgcr8gt2/tm1 cells ...
Cei Abreu-Goodger (10072), Pentao Liu (31036), Peri H. Tate (142031), Nenad Bartonicek (142034), Matthew P. A. Davis (141453), Stijn van Dongen (14147), Anton J. Enright (14148), Claudia Kutter (61195), William C. Skarnes (14113), Dong Lu (141452), Ian Dunham (6370)   +10 more
core   +1 more source

DGCR8 microprocessor defect and deregulation of its expression in thyroid lesions [PDF]

, 2021
Deregulation of microRNA (miRNA) processing is a driver event in several tumors including thyroid cancer. DiGeorge Critical Region 8 (DGCR8) gene holds a critical role in miRNA biogenesis, as a microprocessor complex componente, and in the development of
Rodrigues, Lia Cristiana Gomes
core  

Germ cell-specific depletion of miRNAs in GC-Dcr1 and GC-Dgcr8 mutant testes.

, 2014
(A) Schematic representation of Dicer1 and Dgcr8 loci. Exon 24 of the Dicer1 gene is flanked with loxP sites (grey triangles) and excision occurs upon Ddx4-Cre recombinase expression leading to loss of the RNaseIII domain 2.
Noora Kotaja (202349), Christelle Borel (138807), Adem Bilican (632631), Henrik Kaessmann (11329), Céline Zimmermann (558274), Maria Warnefors (325838), Lee B. Smith (161960), Yannick Romero (105364), Serge Nef (45552)   +8 more
core   +1 more source

Data_Sheet_1_Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development.PDF

, 2020
Dgcr8 is involved in the biogenesis of canonical miRNAs to process pri-miRNA into pre-miRNA. Previous studies have provided evidence that Dgcr8 plays an essential role in different biological processes. However, the function of maternal and zygotic Dgcr8
Yuxin Xie (4527673), Taian Liu (6171032), Yun Liu (84346), Ou Sha (8640885), Zeyao Zhu (8640879), Wen Xu (292544), Kathy W. Y. Sham (8640882), Christopher H. K. Cheng (8640888)   +7 more
core   +1 more source

Knockdown of DGCR8 using DsiRNA.

, 2014
(A) Relative expression of DGCR8 gene measured by qPCR verifying knockdown. (n = 3, **** = p values of
Yan Long Edmund Lui (601898), Louise Marie Hafner (601900), Kian Hwa Tan (366805), Tuan Lin Tan (57411), Wee Hong Woo (601899), Eng Lee Tan (167237), Peter Timms (206543)   +6 more
core   +1 more source

Candidate Dgcr8-independent miRNAs.

, 2012
Presented are the candidate Dgcr8-independent miRNAs alongside those identified as Dgcr8-independent by Babiarz et al.[25]. Included is the fold change of each miRNA seen in this study between heterozygous and Dgcr8-depleted cell lines (bold italics if ...
Cei Abreu-Goodger (10072), Pentao Liu (31036), Peri H. Tate (142031), Nenad Bartonicek (142034), Matthew P. A. Davis (141453), Stijn van Dongen (14147), Anton J. Enright (14148), Claudia Kutter (61195), William C. Skarnes (14113), Dong Lu (141452), Ian Dunham (6370)   +10 more
core   +1 more source

Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.

, 2012
The RNA-binding protein DiGeorge Critical Region 8 (DGCR8) and its partner nuclease Drosha are essential for processing of microRNA (miRNA) primary transcripts (pri-miRNAs) in animals.
Barr, Ian, Chen, Yanqiu, Senturia, Rachel, Smith, Aaron T, Burstyn, Judith N, Guo, Feng   +5 more
core   +1 more source

DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking immunoprecipitation (HITS-CLIP) we
Cáceres, Javier F., Macias, Sara, Stajuda, Agata, Michlewski, Gracjan, Eyras Jiménez, Eduardo, Plass Pórtulas, Mireya, 1982-   +5 more
core  

Crystal structure of human DGCR8 core [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2008
W.J. Bae, S.Y. Sohn, J.J. Kim, Y. Cho
openaire   +1 more source

METTL3 Promotes m6A-Dependent Maturation of pri-miR-150 to Regulate Proliferation of Esophageal Squamous Cell Carcinoma

Zhongliu Fangzhi Yanjiu
ObjectiveTo explore the regulatory mechanism of methyltransferase like protein 3 (METTL3)–mediated m6A methylation in promoting pri-microRNA 150 (miR-150) maturation in esophageal squamous cell carcinoma (ESCC).
Leilei SONG, Jingjing ZHANG, Hui WU, Zeyu XU   +3 more
doaj   +1 more source