Results 131 to 140 of about 10,226 (209)

Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala

Cell Reports, 2017
Individuals with 22q11.2 deletion syndrome (22q11DS) are at high risk of developing psychiatric diseases such as schizophrenia. Individuals with 22q11DS and schizophrenia are impaired in emotional memory, anticipating, recalling, and assigning a correct ...
Tae-Yeon Eom, Ildar T. Bayazitov, Kara Anderson, Jing Yu, Stanislav S. Zakharenko   +4 more
doaj   +1 more source

DGCR8 microprocessor defect and deregulation of its expression in thyroid lesions

, 2021
Deregulation of microRNA (miRNA) processing is a driver event in several tumors including thyroid cancer. DiGeorge Critical Region 8 (DGCR8) gene holds a critical role in miRNA biogenesis, as a microprocessor complex componente, and in the development of
Rodrigues, Lia Cristiana Gomes
core  

Germ cell-specific depletion of miRNAs in GC-Dcr1 and GC-Dgcr8 mutant testes.

, 2014
(A) Schematic representation of Dicer1 and Dgcr8 loci. Exon 24 of the Dicer1 gene is flanked with loxP sites (grey triangles) and excision occurs upon Ddx4-Cre recombinase expression leading to loss of the RNaseIII domain 2.
Noora Kotaja (202349), Christelle Borel (138807), Adem Bilican (632631), Henrik Kaessmann (11329), Céline Zimmermann (558274), Maria Warnefors (325838), Lee B. Smith (161960), Yannick Romero (105364), Serge Nef (45552)   +8 more
core   +1 more source

Data_Sheet_1_Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development.PDF

, 2020
Dgcr8 is involved in the biogenesis of canonical miRNAs to process pri-miRNA into pre-miRNA. Previous studies have provided evidence that Dgcr8 plays an essential role in different biological processes. However, the function of maternal and zygotic Dgcr8
Yuxin Xie (4527673), Taian Liu (6171032), Yun Liu (84346), Ou Sha (8640885), Zeyao Zhu (8640879), Wen Xu (292544), Kathy W. Y. Sham (8640882), Christopher H. K. Cheng (8640888)   +7 more
core   +1 more source

MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex

, 2014
SummaryLoss- and gain-of-function mutations of the X-linked gene MECP2 (methyl-CpG binding protein 2) lead to severe neurodevelopmental disorders in humans, such as Rett syndrome (RTT) and autism.
Zhu, Ying, Qiu, Zilong, Xu, Wenqing, Liao, Qiuming, Zhou, Wen-Hao, Cheng, Tian-Lin, Wang, Zhizhi   +6 more
core   +1 more source

Effect of DGCR8 Knockdown on regulation of HBEGF by O₂.

, 2016
Western blots of DGCR8 in lysates of HTR-8/SVneo cells treated for 48 hr with (A) 5 nM or 10 nM of three different DGCR8 siRNA and (B) different pairings of the three siRNA (5nM). C-F. DGCR8 (~120kDa), HBEGF (~22kDa) and β-actin (~45kDa) were assessed in
Meritxell Jodar (3193284), Chandni V. Jain (3193281), D. Randall Armant (3193278), Philip Jessmon (3193290), Stephen A. Krawetz (113433), Brian A. Kilburn (3193293), Edward Sendler (3193287)   +6 more
core   +1 more source

Crystal structure of human DGCR8 core [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2008
W.J. Bae, S.Y. Sohn, J.J. Kim, Y. Cho
openaire   +1 more source

Tumor Promoting Role of NRIP1 in Oral Squamous Cell Carcinoma: The Involvement of NSD2-Mediated Histone Methylation of DGCR8.

Tohoku journal of experimental medicine, 2023
Lili Zhang, Guangyao Hu
semanticscholar   +1 more source

DGCR8 Gene [PDF]

, 2020
openaire   +1 more source

DGCR8 wt Allele [PDF]

, 2020
openaire   +1 more source