Results 141 to 150 of about 10,226 (209)

DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking immunoprecipitation (HITS-CLIP) we
Cáceres, Javier F., Macias, Sara, Stajuda, Agata, Michlewski, Gracjan, Eyras Jiménez, Eduardo, Plass Pórtulas, Mireya, 1982-   +5 more
core  

Sylamer plots of miRNA seed enrichment amongst genes whose expression changes following Dgcr8 depletion.

, 2012
A) Heterozygote vs. Dgcr8-depleted cells. Independent homozygous mutant and heterozygous cell lines are considered replicates. Array probes and associated transcripts were sorted according to log fold change in Dgcr8gt1/tm1 and Dgcr8gt2/tm1 cells ...
Cei Abreu-Goodger (10072), Pentao Liu (31036), Peri H. Tate (142031), Nenad Bartonicek (142034), Matthew P. A. Davis (141453), Stijn van Dongen (14147), Anton J. Enright (14148), Claudia Kutter (61195), William C. Skarnes (14113), Dong Lu (141452), Ian Dunham (6370)   +10 more
core   +1 more source

DGCR8 Phosphorylation is Required for the Repair of UV-induced DNA Lesions Independently of MicroRNA Processing

, 2015
Thesis (Ph.D.)--University of Washington, 2015Ultraviolet (UV) radiation generates toxic and mutagenic DNA lesions such as cyclobutane pyrimidine dimers (CPDs) and 6-4 pyrimidine-pyrimidone photoproducts (6-4PPs) and is a carcinogen.
Calses, Philamer
core  

Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation

, 2019
DiGeorge syndrome chromosomal region 8 (DGCR8), a double-stranded-RNA-binding protein,participates in the miRNA biogenesis pathway and contributes to miRNA maturation by interactingwith the RNAase III enzyme Drosha in cell nuclei. To investigate the role
Junming Yue (6418612)
core   +1 more source

DGCR8 Gene Mutation [PDF]

, 2020
openaire   +1 more source

Dual function of ERH in primary miRNA biogenesis. [PDF]

Nucleic Acids Res
Aschenwald S, Panda AK, Wurzer T, Baumgärtner S, Ertl VS, Hatzer J, Villunger A, Falk S, Herzog S.   +8 more
europepmc   +2 more sources

Microprocessor Complex Subunit DGCR8 [PDF]

, 2020
openaire   +1 more source

METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes

Journal of Cardiothoracic Surgery
Background Hypoxia/reoxygenation (H/R) induces cardiomyocyte ferroptosis, a core remodeling event in myocardial ischemia/reperfusion injury. Methyltransferase-like 14 (METTL14) emerges as a writer of N6-methyladenosine (m6A) modification.
Chunyu Zhao, Jianing Li
doaj   +1 more source

Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance. [PDF]

Genes Dev
Shang R, Popitsch N, Lee S, Ameres SL, Lai EC.   +4 more
europepmc   +2 more sources

Canonical microRNA loss drives tumor development, implicating therapeutic efficacy of enoxacin in angiosarcoma. [PDF]

RNA
Liu B, Murphy A, Benton A, Gartenhaus L, Budka W, Bronzini JM, Hartzler S, Yates ME, Alzate AR, Janson ND, Jayasundara S, Utturkar S, Lanman NA, Kazemian M, Hanna JA.   +14 more
europepmc   +1 more source