Results 161 to 170 of about 9,673 (191)
MicroRNA chemical modifications in post-transcriptional gene silencing and human diseases. [PDF]
Mol Ther Nucleic AcidsAlaei A, Kakumani PK.
europepmc +1 more source
Non-Coding RNAs from Cardiac Development to Disease: Regulatory Context, Regenerative Potential, and Translational Limits. [PDF]
Int J Mol SciWang L, Zhao Y, Zhang R, Ning X, Jin B.
europepmc +1 more source
Posttranscriptional Crossregulation Between Drosha and DGCR8 [PDF]
Cell, 2009 SummaryThe Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate.
Young-Kook Kim +2 more
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DGCR8 Microprocessor Subunit Mutation and Expression Deregulation in Thyroid Lesions
International Journal of Molecular Sciences, 2022 DGCR8 emerged recently as miRNAs biogenesis pathway protein with a highlighted role in thyroid disease. This study aimed to characterize this miRNA biogenesis component, in particular the p.(E518K) mutation and DGCR8 expression in a series of thyroid lesions. The series of thyroid lesions was genotyped for the c.1552G>A p.(E518K) mutation.
Sofia Macedo +2 more
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Dgcr8 Controls Neural Crest Cells Survival in Cardiovascular Development
Developmental Biology, 2012 DiGeorge syndrome (DGS), characterized genetically by a deletion within chromosome 22q11.2, is associated with a constellation of congenital heart defects. DiGeorge critical region 8 (Dgcr8), a gene that maps to the common deletion region of DGS, encodes a double stranded RNA-binding protein that is essential for miRNA biogenesis.
Robert Blelloch +2 more
exaly +3 more sources
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Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins
Experimental Cell Research, 2007We identified 11 proteins that are associated with DGCR8 by immunoprecipitation assay and mass spectrometry. These proteins included Nucleolin, ILF3 and others, most of which appeared to be involved in the RNA processing or RNA transportation. We detected at least four kinds of protein complex, such as DROSHA/DGCR8, DGCR8/Nucleolin, DGCR8/ILF3 and ILF3/
Aiko, Shiohama +4 more
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DGCR8 Is Essential for Tumor Progression Following PTEN Loss in the Prostate [PDF]
EMBO Reports, 2015 In human prostate cancer, the microRNA biogenesis machinery increases with prostate cancer progression. Here, we show that deletion of the Dgcr8 gene, a critical component of this complex, inhibits tumor progression in a Pten-knockout mouse model of prostate cancer.
Christopher C Benz +2 more
exaly +5 more sources