Results 191 to 200 of about 10,226 (209)
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Experimental Dermatology
Primary cutaneous melanoma (PCM) is an aggressive skin cancer. Its physiopathology is a challenge with heterogeneous pathways involved. As such, microRNA‐processing enzymes have been shown to be deregulated in cancer.
Fabiola Schafer +7 more
semanticscholar +1 more source
Primary cutaneous melanoma (PCM) is an aggressive skin cancer. Its physiopathology is a challenge with heterogeneous pathways involved. As such, microRNA‐processing enzymes have been shown to be deregulated in cancer.
Fabiola Schafer +7 more
semanticscholar +1 more source
Abstract 1549: The tumorigenesis model in DGCR8 associated schwannomatosis
Cancer Research, 2022Purpose: Schwannomatosis is an inherited disorder that affects Schwann cells from peripheral nerves. It is diagnosed when multiple schwannomas occur in the absence of bilateral vestibular schwannomas.
C. Nogué +10 more
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Theriogenology
DiGeorge syndrome critical region gene 8 (DGCR8), a key regulator of mammalian miRNA synthesis, influences early embryonic development. To clarify its role in yak embryos, we generated embryos by in vitro fertilization and microinjected DGCR8-specific ...
Lan Zhang +6 more
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DiGeorge syndrome critical region gene 8 (DGCR8), a key regulator of mammalian miRNA synthesis, influences early embryonic development. To clarify its role in yak embryos, we generated embryos by in vitro fertilization and microinjected DGCR8-specific ...
Lan Zhang +6 more
semanticscholar +1 more source
Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo
Cellular and Molecular Life Sciences, 2019Biologic function of the majority of microRNAs (miRNAs) is still unknown. Uncovering the function of miRNAs is hurdled by redundancy among different miRNAs. The deletion of Dgcr8 leads to the deficiency in producing all canonical miRNAs, therefore, overcoming the redundancy issue.
Wen-Ting Guo, Yangming Wang
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Germline-specific dgcr8 knockout in zebrafish using a BACK approach
Cellular and Molecular Life Sciences, 2017Zebrafish is an important model to study developmental biology and human diseases. However, an effective approach to achieve spatial and temporal gene knockout in zebrafish has not been well established. In this study, we have developed a new approach, namely bacterial artificial chromosome-rescue-based knockout (BACK), to achieve conditional gene ...
Yun, Liu +8 more
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The microprocessor component, DGCR8, is essential for early B‐cell development in mice
European Journal of Immunology, 2016microRNAs (miRNAs) are important posttranscriptional regulators during hematopoietic lineage commitment and lymphocyte development. Mature miRNAs are processed from primary miRNA transcripts in two steps by the microprocessor complex, consisting of Drosha and its partner DiGeorge Critical Region 8 (DGCR8), and the RNAse III enzyme, Dicer.
Andreas Brandl +2 more
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Drosha and DGCR8 in MicroRNA Biogenesis
2012Abstract Drosha and DGCR8 (also called Pasha), together known as the Microprocessor complex, are responsible for cleaving canonical microRNA primary transcripts (pri-miRNAs) to produce microRNA precursors (pre-miRNAs) in animals. This specific cleavage serves as the entrance to the microRNA (miRNA) maturation pathway.
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Role of DGCR8 in differentiation and function of murine macrophages
2021One-third of the world population is latently infected with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Mtb is an intracellular bacterium that developed successful survival strategies to subvert innate and adaptive immune responses and to replicate in host macrophages.
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Role of SNHG14/ DGCR8 in the clear cell renal cell carcinoma
Minerva Medica, 2022Yunbo, Bai +4 more
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