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DGCR8 Expression Is Altered in Children With Congenital Heart Defects
Clinica Chimica Acta, 2019To explore the correlation of DGCR8 expression in children with congenital heart defects (CHD) and its clinical significance.Full blood samples were collected from children with congenital heart disease(n = 40) and healthy children(n = 40), respectively.Real-time PCR was used to detect the expression of DGCR8 in the blood of healthy children and CHD ...
Junming Yue, Yuqi Guo, Taibing Fan
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DGCR8 promotes nascent transcription independently of DROSHA
Biochemical and Biophysical Research CommunicationsDiGeorge syndrome critical region gene 8 (DGCR8) is best known as the RNA-binding subunit of the microprocessor complex required for canonical microRNA (miRNA) biogenesis. Whether DGCR8 also exerts a direct, microprocessor-independent function in the RNA polymerase II (Pol II) transcription cycle remains unclear.
Jin Wang +4 more
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Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo
Cellular and Molecular Life Sciences, 2019Biologic function of the majority of microRNAs (miRNAs) is still unknown. Uncovering the function of miRNAs is hurdled by redundancy among different miRNAs. The deletion of Dgcr8 leads to the deficiency in producing all canonical miRNAs, therefore, overcoming the redundancy issue.
Wen-Ting Guo, Yangming Wang
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Germline-specific dgcr8 knockout in zebrafish using a BACK approach
Cellular and Molecular Life Sciences, 2017Zebrafish is an important model to study developmental biology and human diseases. However, an effective approach to achieve spatial and temporal gene knockout in zebrafish has not been well established. In this study, we have developed a new approach, namely bacterial artificial chromosome-rescue-based knockout (BACK), to achieve conditional gene ...
Yun, Liu +8 more
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Drosha and DGCR8 in MicroRNA Biogenesis
2012Abstract Drosha and DGCR8 (also called Pasha), together known as the Microprocessor complex, are responsible for cleaving canonical microRNA primary transcripts (pri-miRNAs) to produce microRNA precursors (pre-miRNAs) in animals. This specific cleavage serves as the entrance to the microRNA (miRNA) maturation pathway.
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The microprocessor component, DGCR8, is essential for early B‐cell development in mice
European Journal of Immunology, 2016microRNAs (miRNAs) are important posttranscriptional regulators during hematopoietic lineage commitment and lymphocyte development. Mature miRNAs are processed from primary miRNA transcripts in two steps by the microprocessor complex, consisting of Drosha and its partner DiGeorge Critical Region 8 (DGCR8), and the RNAse III enzyme, Dicer.
Bosl, MR +8 more
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Role of DGCR8 in differentiation and function of murine macrophages
2021One-third of the world population is latently infected with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Mtb is an intracellular bacterium that developed successful survival strategies to subvert innate and adaptive immune responses and to replicate in host macrophages.
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Effects of METTL3-METTL14 on primary microRNA processing by Drosha-DGCR8
Abstract MicroRNAs modulate most protein-coding genes, and many are regulated during maturation. Chemical modifications of primary transcripts containing microRNAs have been implicated in altering Microprocessor processing efficiency, a key initiating endonucleolytic step performed by Drosha and DGCR8.Brijesh Khadgi, Yunsun Nam
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Role of SNHG14/ DGCR8 in the clear cell renal cell carcinoma
Minerva Medica, 2022Yunbo, Bai +4 more
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DGCR8-Dependent Efficient Pri-miRNA Processing of Human Pri-miR-9-2
Journal of Biological Chemistry, 2021Hideyuki Okano +2 more
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