Results 181 to 190 of about 10,226 (209)
Posttranscriptional Crossregulation between Drosha and DGCR8 [PDF]
Cell, 2009 SummaryThe Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate.
Jinju Han +2 more
exaly +6 more sources
Dgcr8 controls neural crest cells survival in cardiovascular development
Developmental Biology, 2012 DiGeorge syndrome (DGS), characterized genetically by a deletion within chromosome 22q11.2, is associated with a constellation of congenital heart defects. DiGeorge critical region 8 (Dgcr8), a gene that maps to the common deletion region of DGS, encodes
Elik Chapnik +2 more
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins
Experimental Cell Research, 2007We identified 11 proteins that are associated with DGCR8 by immunoprecipitation assay and mass spectrometry. These proteins included Nucleolin, ILF3 and others, most of which appeared to be involved in the RNA processing or RNA transportation. We detected at least four kinds of protein complex, such as DROSHA/DGCR8, DGCR8/Nucleolin, DGCR8/ILF3 and ILF3/
Aiko, Shiohama +4 more
openaire +2 more sources
Developmental Biology, 2023
The DGCR8 gene, encoding a critical miRNA processing protein, maps within the hemizygous region in patients with 22q11.2 deletion syndrome. Most patients have malformations of the cardiac outflow tract that is derived in part from the anterior second ...
S. Racedo +4 more
semanticscholar +1 more source
The DGCR8 gene, encoding a critical miRNA processing protein, maps within the hemizygous region in patients with 22q11.2 deletion syndrome. Most patients have malformations of the cardiac outflow tract that is derived in part from the anterior second ...
S. Racedo +4 more
semanticscholar +1 more source
Effects of METTL3-METTL14 on primary microRNA processing by Drosha-DGCR8
bioRxivAbstract MicroRNAs modulate most protein-coding genes, and many are regulated during maturation. Chemical modifications of primary transcripts containing microRNAs have been implicated in altering Microprocessor processing efficiency, a key initiating endonucleolytic step performed by Drosha and DGCR8.
Brijesh B Khadgi, Y. Nam
semanticscholar +3 more sources
DGCR8 expression is altered in children with congenital heart defects
Clinica Chimica Acta, 2019To explore the correlation of DGCR8 expression in children with congenital heart defects (CHD) and its clinical significance.Full blood samples were collected from children with congenital heart disease(n = 40) and healthy children(n = 40), respectively.Real-time PCR was used to detect the expression of DGCR8 in the blood of healthy children and CHD ...
Qun Li, Taibing Fan, Junming Yue
exaly +3 more sources
DGCR8 and the six hit, three-step model of schwannomatosis
Acta Neuropathologica, 2021C. Nogué +10 more
semanticscholar +2 more sources
Journal of Gastroenterology and Hepatology, 2022
N6‐methyladenosine (m6A) is the most prevalent methylation modification of eukaryotic RNA, and methyltransferase‐like 3 (METTL3) plays a vital role in multiple cell functions.
W. Gong, Rong Li, Q. Dai, YU Peng
semanticscholar +1 more source
N6‐methyladenosine (m6A) is the most prevalent methylation modification of eukaryotic RNA, and methyltransferase‐like 3 (METTL3) plays a vital role in multiple cell functions.
W. Gong, Rong Li, Q. Dai, YU Peng
semanticscholar +1 more source