Results 121 to 130 of about 10,226 (209)

Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages.

PLoS ONE, 2016
We aimed to determine the levels of microRNAs (miRNAs) in sera and HDL of acute coronary syndrome (ACS) compared to stable angina (SA) patients with/without hyperglycemia, and evaluate comparatively the functional effect of these sera on the processing ...
Natalia Simionescu, Loredan S Niculescu, Mihaela G Carnuta, Gabriela M Sanda, Camelia S Stancu, Andreea C Popescu, Mihaela R Popescu, Adelina Vlad, Doina R Dimulescu, Maya Simionescu, Anca V Sima   +10 more
doaj   +1 more source

Whispers of Growth: The Impact of MicroRNA on the Proliferation Potential of Adipose‐Derived Stem Cells—A Review

BioMed Research International, Volume 2026, Issue 1, 2026.
Adipose‐derived stem cells (ADSCs) have garnered significant interest in regenerative medicine (RM) due to their abundant availability, ease of isolation, and ability to differentiate into various cell types. The growth of ADSCs is crucial for their therapeutic effectiveness, as it directly influences their ability to repair damaged tissues. MicroRNAs (
Maryam Bahrami, Hojjat Allah Abbaszadeh, Katayon Berjis, Ali Moradi, Ruixi Luo   +4 more
wiley   +1 more source

Gemcitabine exhibits a suppressive effect on pancreatic cancer cell growth by regulating processing of PVT1 to miR1207

Molecular Oncology, 2018
Gemcitabine serves as a first‐line chemotherapy agent for advanced pancreatic cancer (PC). However, the molecular basis by which gemcitabine exerts its effects is not well‐established, and the targeted genetic pathways remain unclear.
Lei You, Huanyu Wang, Gang Yang, Fangyu Zhao, Jingcheng Zhang, Ziwen Liu, Taiping Zhang, Zhiyong Liang, Changzheng Liu, Yupei Zhao   +9 more
doaj   +1 more source

Data_Sheet_1_Upregulation of DGCR8, a Candidate Predisposing to Schizophrenia in Han Chinese, Contributes to Phenotypic Deficits and Neuronal Migration Delay.pdf

, 2022
DiGeorge Syndrome Critical Region Gene 8 (DGCR8) is a key component of the microprocessor complex governing the maturation of most microRNAs, some of which participate in schizophrenia and neural development.
Lei Ji (318794), Tao Yu (176965), Xi Wu (128938), Shunying Yu (298741), Weibo Niu (7834406), Zhenming Guo (11651496), Ke Han (303537), Lu Wang (45927), Yi Shi (169113), Guang He (225824), Fan Yuan (110554), Lin He (102807), Decheng Ren (8177439), Liangjie Liu (10307372), Xingwang Li (283480), Jing Zhang (23775), Shiqing Chen (3570338), Weidong Li (292436), Qi Shen (166827), Yifeng Xu (721596), Fengping Yang (11651502), Yan Bi (289639)   +21 more
core   +1 more source

MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?

European Thyroid Journal
In recent years, germline mutations in the microRNA (miRNA) processor genes DICER1 and DGCR8 have been coupled to the development of thyroid follicular nodular disease (TFND), thereby casting new light on the etiology of this enigmatic, benign condition ...
Vincenzo Condello, C Christofer Juhlin
doaj   +1 more source

Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice [PDF]

, 2017
DGCR8 is an RNA-binding protein that interacts with DROSHA to produce pre-microRNA in the nucleus, while DICER generates not only mature microRNA, but also endogenous small interfering RNAs in the cytoplasm.
김형범
core   +1 more source

DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures

, 2010
DiGeorge critical region 8 (DGCR8) is essential for maturation of microRNAs (miRNAs) in animals. In the cleavage of primary transcripts of miRNAs (pri-miRNAs) by the Drosha nuclease, the DGCR8 protein directly binds and recognizes pri-miRNAs through a ...
Z. Hong Zhou, Rachel Senturia, Michael Faller, Michio Matsunaga, Daniel Toso, Yanqiu Chen, Ivo Atanasov, Feng Guo   +7 more
core   +1 more source

Cobalt(III) protoporphyrin activates the DGCR8 protein and can compensate microRNA processing deficiency [PDF]

, 2015
Processing of microRNA primary transcripts (pri-miRNAs) is highly regulated and defects in the processing machinery play a key role in many human diseases. In 22q11.2 deletion syndrome (22q11.2DS), heterozygous deletion of DiGeorge critical region gene 8
Weitz, Sara H., Karayiorgou, Maria, Barr, Ian, Weitz, Sara H, Weiss, Shimon, Hsu, PeiKen, Guo, Feng, Atkin, Talia, Gogos, Joseph A., Gogos, Joseph A   +9 more
core   +1 more source

MicroRNA dysregulation, gene networks and risk for schizophrenia in 22q11.2 deletion syndrome

Frontiers in Neurology, 2014
The role of microRNAs (miRNAs) in the aetiology of schizophrenia is increasingly recognized. Microdeletions at chromosome 22q11.2 are recurrent structural variants that impart a high risk for schizophrenia and are found in up to 1% of all patients with ...
Daniele eMerico, Gregory eCostain, Gregory eCostain, Nancy eButcher, Nancy eButcher, William eWarnica, Lucas eOgura, Simon E Alfred, Linda eBrzustowicz, Anne eBassett, Anne eBassett, Anne eBassett, Anne eBassett, Anne eBassett   +13 more
doaj   +1 more source

Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression

Cell Reports
Summary: Sperm small RNAs have emerged as important non-genetic contributors to embryogenesis and offspring health. A subset of sperm small RNAs is thought to be acquired during epididymal transit.
Natalie A. Trigg, Colin C. Conine
doaj   +1 more source