Results 101 to 110 of about 9,673 (191)

Meiotic defects in GC-Dcr1 and GC-Dgcr8 mutant testes.

, 2014
(A–D) Anti-γH2AX (green), present in the entire nucleus in early meiotic stages and located to the XY body during the pachytene stage, indicates a decreased number of tubules containing XY body positive cells in GC-Dcr1 and GC-Dgcr8 mutant testes ...
Noora Kotaja (202349), Christelle Borel (138807), Adem Bilican (632631), Henrik Kaessmann (11329), Céline Zimmermann (558274), Maria Warnefors (325838), Lee B. Smith (161960), Yannick Romero (105364), Serge Nef (45552)   +8 more
core   +1 more source

Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages.

PLoS ONE, 2016
We aimed to determine the levels of microRNAs (miRNAs) in sera and HDL of acute coronary syndrome (ACS) compared to stable angina (SA) patients with/without hyperglycemia, and evaluate comparatively the functional effect of these sera on the processing ...
Natalia Simionescu, Loredan S Niculescu, Mihaela G Carnuta, Gabriela M Sanda, Camelia S Stancu, Andreea C Popescu, Mihaela R Popescu, Adelina Vlad, Doina R Dimulescu, Maya Simionescu, Anca V Sima   +10 more
doaj   +1 more source

Mutationen des DROSHA/DGCR8 Mikroprozessor-Komplexes in blastemreichen Hochrisiko-Wilms Tumoren

, 2022
Wilms tumor (WT) or nephroblastoma is the most common kidney tumor in childhood. Several genetic alterations have been identified in WT over the past years. However, a clear-cut underlying genetic defect has remained elusive.
Vardapour, Romina
core   +1 more source

MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?

European Thyroid Journal
In recent years, germline mutations in the microRNA (miRNA) processor genes DICER1 and DGCR8 have been coupled to the development of thyroid follicular nodular disease (TFND), thereby casting new light on the etiology of this enigmatic, benign condition ...
Vincenzo Condello, C Christofer Juhlin
doaj   +1 more source

Gemcitabine exhibits a suppressive effect on pancreatic cancer cell growth by regulating processing of PVT1 to miR1207

Molecular Oncology, 2018
Gemcitabine serves as a first‐line chemotherapy agent for advanced pancreatic cancer (PC). However, the molecular basis by which gemcitabine exerts its effects is not well‐established, and the targeted genetic pathways remain unclear.
Lei You, Huanyu Wang, Gang Yang, Fangyu Zhao, Jingcheng Zhang, Ziwen Liu, Taiping Zhang, Zhiyong Liang, Changzheng Liu, Yupei Zhao   +9 more
doaj   +1 more source

Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation

, 2019
DiGeorge syndrome chromosomal region 8 (DGCR8), a double-stranded-RNA-binding protein,participates in the miRNA biogenesis pathway and contributes to miRNA maturation by interactingwith the RNAase III enzyme Drosha in cell nuclei. To investigate the role
Junming Yue (6418612)
core   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for histopathology

Histopathology, Volume 88, Issue 7, Page 1291-1294, June 2026.
Ian A Cree, Mark J Arends, Joseph D Khoury, Erika RE Denton, Anthony J Gill, Alexander J Lazar, Ian M Frayling, Stefan M Pfister, Mark A Rubin, Katia RM Leite, Raymond Dalgleish, Elspeth A Bruford, Sharon Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage

, 2015
The DNA damage response network stimulates microRNA (miRNA) biogenesis to coordinate repair, cell cycle checkpoints, and apoptosis. The multistep process of miRNA biogenesis involves the cleavage of primary miRNAs by the microprocessor complex composed ...
Chi-Chiang Tu, Sridevi, Priya, Priya Sridevi, Yan Zhong, Tu, Chi-Chiang, Nguyen, Louis, Wang, Jean YJ, Woan-Yuh Tarn, Zhong, Yan, Tsai, Aaron, Louis Nguyen, Aaron Tsai, Jean Y. J. Wang, Tarn, Woan-Yuh   +13 more
core   +1 more source

Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression

Cell Reports
Summary: Sperm small RNAs have emerged as important non-genetic contributors to embryogenesis and offspring health. A subset of sperm small RNAs is thought to be acquired during epididymal transit.
Natalie A. Trigg, Colin C. Conine
doaj   +1 more source

Studies on the Interaction of DGCR8 with the Cofactor Heme. [PDF]

, 2012
The RNA-binding protein DiGeorge Critical Region 8 (DGCR8) and its partner, the nuclease Drosha, are necessary for processing of primary microRNA (pri-miRNA) transcripts in animals.
Barr, Robert Ian
core