Results 71 to 80 of about 10,226 (209)

Analysis of heme iron coordination in DGCR8: The heme-binding component of the microprocessor complex [PDF]

, 2016
DGCR8 is the RNA-binding partner of the nuclease Drosha. Their complex (the “Microprocessor”) is essential for processing of long, primary microRNAs (pri-miRNAs) in the nucleus. Binding of heme to DGCR8 is essential for pri-miRNA processing. On the basis
Yilin Liu (1991839), Myles R. Cheesman (1353777), Fisher, Karl, David Leys (1328622), Justin M. Bradley (2137579), Karl Fisher (1740823), Rigby, Stephen E. J., Bradley, Justin M., Kincaid, James R., James R. Kincaid (1313820), Kazimierz Czarnecki (1928854), Cheesman, Myles R., Liu, Yilin, Czarnecki, Kazimierz, Stephen E. J. Rigby (110349), Leys, David, Munro, Andrew W., Hazel M. Girvan (3093705), Andrew W. Munro (237207), Girvan, Hazel M.   +19 more
core   +1 more source

The DGCR8 RNA-Binding Heme Domain Recognizes Primary MicroRNAs by Clamping the Hairpin

Cell Reports, 2014
Canonical primary microRNA transcripts (pri-miRNAs) are characterized by a ∼30 bp hairpin flanked by single-stranded regions. These pri-miRNAs are recognized and cleaved by the Microprocessor complex consisting of the Drosha nuclease and its obligate RNA-
Jen Quick-Cleveland, Jose P. Jacob, Sara H. Weitz, Grant Shoffner, Rachel Senturia, Feng Guo   +5 more
doaj   +1 more source

Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene

Genes, 2022
Maturation of microRNAs (miRNAs) begins by the “Microprocessor” complex, containing the Drosha endonuclease and its partner protein, "DiGeorge Syndrome Critical Region 8" (DGCR8).
D. Reé, Á. Fóthi, N. Varga, Orsolya Kolacsek, T. Orbán, Á. Apáti   +5 more
semanticscholar   +1 more source

Canonical MicroRNA Activity Facilitates but May Be Dispensable for Transcription Factor-Mediated Reprogramming

Stem Cell Reports, 2015
MicroRNAs (miRNAs) are important regulators of reprogramming of somatic cells into induced pluripotent stem cells (iPSCs); however, it is unclear whether miRNAs are required for reprogramming and whether miRNA activity as a whole facilitates ...
Zhong Liu, Maria Skamagki, Kitai Kim, Rui Zhao   +3 more
doaj   +1 more source

RETRACTED ARTICLE: METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner

Cell Death Discovery, 2021
Myocardial infarction (MI), one of the most severe types of heart attack, exerts a strong negative effect on heart muscle by causing a massive and rapid loss of cardiomyocytes.
Kun Zhao, Chuanxi Yang, Jing Zhang, Wei Sun, Bin Zhou, X. Kong, Jing Shi   +6 more
semanticscholar   +1 more source

A DGCR8-Independent Stable MicroRNA Expression Strategy Reveals Important Functions of miR-290 and miR-183–182 Families in Mouse Embryonic Stem Cells

Stem Cell Reports, 2017
Summary: Dgcr8 knockout cells provide a great means to understand the function of microRNAs (miRNAs) in vitro and in vivo. Current strategies to study miRNA function in Dgcr8 knockout cells depend on transient transfection of chemically synthesized miRNA
Xi-Wen Wang, Jing Hao, Wen-Ting Guo, Le-Qi Liao, Si-Yue Huang, Xiangpeng Guo, Xichen Bao, Miguel A. Esteban, Yangming Wang   +8 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Understanding the neuronal functions of diverse RNA pathways will lead to treatments of human neurological diseases that are caused by perturbations in RNA metabolism. Two proteins, Drosha and Pasha/DGCR8, play important roles in neurons, where they are responsible for the biogenesis of many microRNAs.
Arthur, Luhur, Geetanjali, Chawla, Yen-Chi, Wu, Jing, Li, Nicholas S, Sokol   +4 more
openaire   +2 more sources

DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. [PDF]

PLoS ONE, 2013
Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease.
Lukas T Jeker, Xuyu Zhou, Robert Blelloch, Jeffrey A Bluestone   +3 more
doaj   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, EarlyView.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source