Results 31 to 40 of about 15,397 (180)
The Drosha-DGCR8 complex in primary microRNA processing [PDF]
Genes & Development, 2004 RNase III proteins play key roles in microRNA (miRNA) biogenesis. The nuclear RNase III Drosha cleaves primary miRNAs (pri-miRNAs) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic RNase III Dicer to generate mature miRNAs.
Jinju, Han +5 more
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Drosha mediates destabilization of Lin28 mRNA targets [PDF]
Cell Cycle, 2012 Lin28 plays important roles in development, stem cell maintenance, oncogenesis and metabolism. As an RNA-binding protein, it blocks the biogenesis primarily of let-7 family miRNAs and also promotes translation of a cohort of mRNAs involved in cell growth, metabolism and pluripotency, likely through recognition of distinct sequence and structural motifs
Chong, Qiao +5 more
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Drosha Regulates Gene Expression Independently of RNA Cleavage Function
Cell Reports, 2013 Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically binds promoter-proximal ...
Natalia Gromak +6 more
doaj +1 more source
RNA Biology, 2022 The RNase III family of dsRNA-specific endonucleases is exemplified by prokaryotic RNase III and eukaryotic Rnt1p, Drosha, and Dicer. Structures of Aquifex aeolicus RNase III (AaRNase III) and Saccharomyces cerevisiae Rnt1p (ScRnt1p) show that both ...
Sudhaker Dharavath +2 more
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The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility
Clinical and Experimental Hypertension, 2018 Purpose: Drosha is a member of the micro RNA (miRNA) processing machinery that affects miRNA processing. Single-nucleotide polymorphisms (SNPs) in the Drosha gene might affect microRNA processing and the expression of various genes. The aim of this study
Mahnaz Rezaei +6 more
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Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia [PDF]
Current Opinion in Hematology, 2019 Purpose of review The TGFβ (transforming growth factor β) superfamily – a large group of structurally related and evolutionarily conserved proteins – profoundly shapes and organizes the vasculature during normal development and adult homeostasis.
Hata, Akiko, Lagna, Giorgio
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Cytoplasmic Drosha activity generated by alternative splicing [PDF]
Nucleic Acids Research, 2016 RNase III enzyme Drosha interacts with DGCR8 to form the Microprocessor, initiating canonical microRNA (miRNA) maturation in the nucleus. Here, we re-evaluated where Drosha functions in cells using Drosha and/or DGCR8 knock out (KO) cells and cleavage reporters.
Dai, Lisheng +8 more
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Alternative splicing affects the subcellular localization of Drosha [PDF]
Nucleic Acids Research, 2016 The RNase III enzyme Drosha is a key factor in microRNA (miRNA) biogenesis and as such indispensable for cellular homeostasis and developmental processes. Together with its co-factor DGCR8, it converts the primary transcript (pri-miRNA) into the precursor hairpin (pre-miRNA) in the nucleus. While the middle and the C-terminal domain are crucial for pri-
Link, Steffen +2 more
openaire +3 more sources
DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs
Molecular Therapy: Nucleic Acids, 2018 RNAi-based gene therapy using miRNA-adapted short hairpin RNAs (shRNAmiR) is a powerful approach to modulate gene expression. However, we have observed low viral titers with shRNAmiR-containing recombinant vectors and hypothesized that this could be due ...
Hee Ho Park +8 more
doaj +1 more source
Endocrine Regulations, 2018 Objectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the
Soufi Farhad Ghadiri +5 more
doaj +1 more source