Results 31 to 40 of about 17,302 (170)

A novel requirement for DROSHA in maintenance of mammalian CG methylation [PDF]

, 2017
In mammals, faithful inheritance of genomic methylation patterns ensures proper gene regulation and cell behaviour, impacting normal development and fertility.
Pradhan, S, Schmitz, RJ, Sriharsa Pradhan, Guoqiang Zhang, Lexiang Ji, Thomas A. Neubert, Javier Herrero, Steen K.T. Ooi, Estève, P-O, Ooi, SKT, Stathopoulou, A, Erdjument-Bromage, H, Pierre-Olivier Estève, Ambrose, JC, Zhang, G, John C. Ambrose, Neubert, TA, Herrero, J, Athanasia Stathopoulou, Ji, L, Hediye Erdjument-Bromage, Chhetri, JB, Jyoti B. Chhetri, Robert J. Schmitz   +23 more
core   +2 more sources

Drosha Expression and Microprocessor Activity in Maturing Bovine Oocytes and Cultured Granulosa Cells [PDF]

, 2021
This thesis investigates localization and expression of RNA-binding protein Drosha within maturing bovine oocytes, and the effect of experimentally inhibiting Drosha on processing several microRNA precursors into mature forms in cumulus cells (CCs ...
Stuart, Deirdre
core   +1 more source

The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition

Endocrine Regulations, 2018
Objectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the
Soufi Farhad Ghadiri, Zonouzi Ali Akbar Poursadegh, Eftekhar Ebrahim, Kamali Kamila, Chegeni Sara Aghakhani, Zonouzi Ahmad Poursadegh   +5 more
doaj   +1 more source

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Cell Reports, 2019
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity.
Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A. Shapiro, Yun-Xing Wang, Shuo Gu   +11 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Acetylation of Drosha increases its protein level.

, 2013
All experiments were repeated three times with similar results ...
Dennis Pantazatos (451804), Sicheng Wen (162284), Dong Zheng (102852), Lynne Tucker (94927), Lulu Cao (128185), Xiaoli Tang (218589), Bharat Ramratnam (218594), Steven F. Moss (162308)   +7 more
core   +1 more source

The Role of DICER and DROSHA Gene Expression in Assessment of Hashimoto Thyroiditis [PDF]

Zagazig University Medical Journal
Background: Hashimoto thyroiditis is autoimmune condition that destroys thyroid follicular cells by immune-mediated mechanisms through the development of anti-thyroid antibodies and T lymphocytes activation , which causes ongoing fibrosis of the thyroid.
Heba Fawzy, Huda E.M.Said, Mohamed Ahmed Abdallah Abdelrahman, Eman A. Abdelaziz   +3 more
doaj   +1 more source

Expression of DROSHA and DICER genes in peripheral blood leukocytes in lung sarcoidosis [PDF]

Терапевтический архив, 2018
Aim. To study the expression level of the genes DROSHA and DICER in peripheral blood leukocytes (PBL) of patients with sarcoidosis of the lungs Materials and methods.
I E Malysheva, O V Balan, E L Tikhonovich, T O Volkova   +3 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function.

PLoS ONE, 2017
Canonical processing of miRNA begins in the nucleus with the Microprocessor complex, which is minimally composed of the RNase III enzyme Drosha and two copies of its cofactor protein DGCR8.
Joshua C Kranick, Durga M Chadalavada, Debashish Sahu, Scott A Showalter   +3 more
doaj   +1 more source