Results 31 to 40 of about 16,723 (215)
Intronic microRNA precursors that bypass Drosha processing [PDF]
Nature, 2007 MicroRNAs (miRNAs) are approximately 22-nucleotide endogenous RNAs that often repress the expression of complementary messenger RNAs. In animals, miRNAs derive from characteristic hairpins in primary transcripts through two sequential RNase III-mediated cleavages; Drosha cleaves near the base of the stem to liberate a approximately 60-nucleotide pre ...
J Graham, Ruby +2 more
openaire +2 more sources
Brazilian Journal of Medical and Biological Research, 2022 The objective of this study was to evaluate the immunohistochemical expression of Dicer, Drosha, and Exportin-5 in the eutopic and ectopic endometrium of women with adenomyosis.
I. Ormenezi +5 more
doaj +1 more source
Drosha: a new tumor suppressor in pineoblastoma. [PDF]
Genes DevTo investigate the pathogenesis and target the vulnerability of human pineoblastoma, researchers have developed multiple genetically engineered mouse models that represent distinct molecular subtypes of the disease. In this issue ofGenes & Development, Fraire and colleagues (doi:10.1101/gad.352485.124) examined the roles of key microRNA (miRNA ...
Huang Z, Ren X, Hu J.
europepmc +3 more sources
PLK1 regulates microRNA biogenesis through Drosha phosphorylation
, 2023 Polo-Like Kinase 1 (PLK1), a key mediator of cell-cycle progression, is associated with poor prognosis and is a therapeutic target in a number of malignancies.
Taylor, Molly +5 more
core +1 more source
Expression levels of Drosha and Dicer enzymes and DGCR8 protein in pre-eclamptic patients [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2018 Introduction: Pre-eclampsia is a serious problem of pregnancy that is associated with proteinuria and increased blood pressure in the second half of pregnancy. It is one of the three leading causes of maternal and fetal mortality. Dysregulated expression
Roghayeh Dargahi +3 more
doaj +1 more source
Drosha mediates destabilization of Lin28 mRNA targets [PDF]
Cell Cycle, 2012 Lin28 plays important roles in development, stem cell maintenance, oncogenesis and metabolism. As an RNA-binding protein, it blocks the biogenesis primarily of let-7 family miRNAs and also promotes translation of a cohort of mRNAs involved in cell growth, metabolism and pluripotency, likely through recognition of distinct sequence and structural motifs
Chong, Qiao +5 more
openaire +2 more sources
RNA Biology, 2022 The RNase III family of dsRNA-specific endonucleases is exemplified by prokaryotic RNase III and eukaryotic Rnt1p, Drosha, and Dicer. Structures of Aquifex aeolicus RNase III (AaRNase III) and Saccharomyces cerevisiae Rnt1p (ScRnt1p) show that both ...
Sudhaker Dharavath +2 more
doaj +1 more source
Cytoplasmic Drosha activity generated by alternative splicing [PDF]
Nucleic Acids Research, 2016 RNase III enzyme Drosha interacts with DGCR8 to form the Microprocessor, initiating canonical microRNA (miRNA) maturation in the nucleus. Here, we re-evaluated where Drosha functions in cells using Drosha and/or DGCR8 knock out (KO) cells and cleavage reporters.
Dai, Lisheng +8 more
openaire +2 more sources
Essential role of the amino-terminal region of Drosha for the Microprocessor function
, 2022 Summary: The ribonuclease (RNase) III enzyme Drosha enables processing of microRNA (miRNA) primary transcripts (pri-miRNAs) and control of ribosomal protein (RP) biogenesis by the Microprocessor.
Hata, Akiko +6 more
core +1 more source
DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs
Molecular Therapy: Nucleic Acids, 2018 RNAi-based gene therapy using miRNA-adapted short hairpin RNAs (shRNAmiR) is a powerful approach to modulate gene expression. However, we have observed low viral titers with shRNAmiR-containing recombinant vectors and hypothesized that this could be due ...
Hee Ho Park +8 more
doaj +1 more source