Results 51 to 60 of about 15,397 (180)

Transcriptomic resources and functional validation of RNAi in the cabbage seedpod weevil, Ceutorhynchus obstrictus

Pest Management Science, EarlyView.
Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis, Triin Kallavus, Éricmar Avila Dos Santos, Liina Soonvald, Riina Kaasik, Silva Vilumets, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +8 more
wiley   +1 more source

Molecular determinants that govern scaRNA processing by Drosha/DGCR8

Biology Open, 2020
The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase. Most scaRNAs, the RNA component of scaRNPs, accumulate in CBs.
Douglas M. McLaurin, Madelyn K. Logan, Katheryn E. Lett, Michael D. Hebert   +3 more
openaire   +3 more sources

RNA activation in insects: From emerging evidence to molecular applications

Insect Molecular Biology, EarlyView.
Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley   +1 more source

Glycogen synthase kinase 3 beta (GSK3β) phosphorylates the RNAase III enzyme Drosha at S300 and S302. [PDF]

PLoS ONE, 2011
The canonical microRNA (miRNA) pathway commences with the enzymatic cleavage of the primary gene transcript (pri-miRNA) by the RNAase III enzyme Drosha in the nucleus into shorter pre-miRNA species that are subsequently exported to the cytoplasm for ...
Xiaoli Tang, Ming Li, Lynne Tucker, Bharat Ramratnam   +3 more
doaj   +1 more source

ECM Substrates Impact RNAi Localization at Adherens Junctions of Colon Epithelial Cells

Cells, 2022
The extracellular matrix (ECM) plays crucial roles in tissue homeostasis. Abnormalities in ECM composition are associated with pathological conditions, such as fibrosis and cancer.
Amanda C. Daulagala, Antonis Kourtidis
doaj   +1 more source

Unveiling isoleucyl‐tRNA synthetase 2 as a novel driver of breast cancer via β‐catenin pathway activation

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Isoleucyl‐tRNA synthetase 2 (IARS2) stabilizes β‐catenin by reducing its phosphorylation at Ser33/37/Thr41 and ubiquitin‐proteasome degradation, thereby promoting β‐catenin nuclear accumulation and transcriptional activation of downstream targets, including inhibitor of DNA binding 3, lactate dehydrogenase A, and Drosha ribonuclease III.
Xi Yang, Ya Wang, Yanjiao Yi, Yang Yang, Hongjiang Wang   +4 more
wiley   +1 more source

Transcription factor binding sites are highly enriched within microRNA precursor sequences

Biology Direct, 2011
Background Transcription factors are thought to regulate the transcription of microRNA genes in a manner similar to that of protein-coding genes; that is, by binding to conventional transcription factor binding site DNA sequences located in or near ...
Piriyapongsa Jittima, Jordan I King, Conley Andrew B, Ronan Tom, Smalheiser Neil R   +4 more
doaj   +1 more source

MicroRNA‐Driven Regulation of β‐Cell Function in Type 2 Diabetes: Molecular Mechanisms, Network Insights, and Translational Perspectives

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β‐cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β‐cell compensation and progressive secretory dysfunction.
Lena Eliasson, Alexandros Karagiannopoulos, Mototsugu Nagao, Anna Wendt   +3 more
wiley   +1 more source

A multifunctional protein EWS regulates the expression of Drosha and microRNAs [PDF]

Cell Death & Differentiation, 2013
EWS (Ewing's Sarcoma) gene encodes an RNA/DNA-binding protein that is ubiquitously expressed and involved in various cellular processes. EWS deficiency leads to impaired development and early senescence through unknown mechanisms. We found that EWS regulates the expression of Drosha and microRNAs (miRNAs).
K Y, Kim, Y J, Hwang, M-K, Jung, J, Choe, Y, Kim, S, Kim, C-J, Lee, H, Ahn, J, Lee, N W, Kowall, Y K, Kim, J-I, Kim, S B, Lee, H, Ryu   +13 more
openaire   +2 more sources

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma [PDF]

Nature Communications, 2018
AbstractPineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients with germline mutations in DICER1, a ribonuclease involved in microRNA processing, have increased risk of pineoblastoma, but genetic drivers of sporadic pineoblastoma remain unknown ...
Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M. Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev, Stacie L. Stapleton, David Zagzag, Luis Chiriboga, Sharon L. Gardner, Jeffrey H. Wisoff, John G. Golfinos, David Capper, Volker Hovestadt, Marc K. Rosenblum, Dimitris G. Placantonakis, Sarah E. LeBoeuf, Thales Y. Papagiannakopoulos, Lukas Chavez, Sama Ahsan, Charles G. Eberhart, Stefan M. Pfister, David T. W. Jones, Matthias A. Karajannis   +28 more
openaire   +3 more sources