Results 51 to 60 of about 16,723 (215)
Acetylation of Drosha increases its protein level.
, 2013 All experiments were repeated three times with similar results ...
Dennis Pantazatos (451804) +7 more
core +1 more source
Modulation of MicroRNA Processing by Dicer via Its Associated dsRNA Binding Proteins
Non-Coding RNA, 2021 MicroRNAs (miRNAs) are small non-coding RNAs that are about 22 nucleotides in length. They regulate gene expression post-transcriptionally by guiding the effector protein Argonaute to its target mRNA in a sequence-dependent manner, causing the ...
Toyotaka Yoshida +2 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Emerging roles of DROSHA beyond primary microRNA processing [PDF]
RNA Biology, 2017 DROSHA is the catalytic subunit of the Microprocessor complex, which initiates microRNA (miRNA) maturation in the nucleus by recognizing and cleaving hairpin precursors embedded in primary transcripts. However, accumulating evidence suggests that not all hairpin substrates of DROSHA are associated with the generation of functional small RNAs.
Dooyoung, Lee, Chanseok, Shin
openaire +2 more sources
Drosha enhances exon 5 splicing.
, 2014 (A) Radiolabelled RT-PCR analysis of endogenous eIF4H splicing, and expression of Drosha, DGCR8, DICER and a loading control, GAPDH, in HEK-293T control cells or following transfection with Drosha, Dicer or TN Drosha. (B) Quantitation of exon 5 splicing.
Mallory A. Havens (558474) +2 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo +5 more
wiley +1 more source
Superimposition of Drosha and Dicer.
, 2019 Front (left) and side (right) views of superimposition of Drosha (sand) upon Dicer (deep blue). Connector domain of Drosha is colored firebrick and of Dicer green-forest.
Rotem Aharoni (8108177) +1 more
core +1 more source
Pest Management Science, EarlyView.Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis +8 more
wiley +1 more source
Molecular determinants that govern scaRNA processing by Drosha/DGCR8
Biology Open, 2020 The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase. Most scaRNAs, the RNA component of scaRNPs, accumulate in CBs.
Douglas M. McLaurin +3 more
openaire +3 more sources
Acetylation and Ubiquitination regulate Drosha protein level.
, 2013 All experiments were repeated three times with similar results ...
Dennis Pantazatos (451804) +7 more
core +1 more source