Results 71 to 80 of about 17,302 (170)

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

The N-terminus of Drosha is responsible for regulating its degradation.

, 2013
HEK293T cells were transfected with an empty vector, GFP-Drosha wild type or the various mutants as indicated. Forty-eight hours post-transfection, whole cell lysates were prepared for western blot. GAPDH was used as a loading control.
Dennis Pantazatos (451804), Sicheng Wen (162284), Dong Zheng (102852), Lynne Tucker (94927), Lulu Cao (128185), Xiaoli Tang (218589), Bharat Ramratnam (218594), Steven F. Moss (162308)   +7 more
core   +1 more source

Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia [PDF]

, 2019
PURPOSE OF REVIEW: The TGFβ (transforming growth factor β) superfamily - a large group of structurally related and evolutionarily conserved proteins - profoundly shapes and organizes the vasculature during normal development and adult homeostasis ...
Hata, Akiko, Akiko Hata, Giorgio Lagna, Lagna, Giorgio   +3 more
core   +1 more source

DNA methylation directs microRNA biogenesis in mammalian cells

Nature Communications, 2019
Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA ...
Ohad Glaich, Shivang Parikh, Rachel E. Bell, Keren Mekahel, Maya Donyo, Yodfat Leader, Ronna Shayevitch, Danna Sheinboim, Sivan Yannai, Dror Hollander, Ze’ev Melamed, Galit Lev-Maor, Gil Ast, Carmit Levy   +13 more
doaj   +1 more source

Knock-down of core proteins regulating microRNA biogenesis has no effect on sensitivity of lung cancer cells to ionizing radiation. [PDF]

PLoS ONE, 2012
Recent studies underline the important role of microRNAs (miRNA) in the development of lung cancer. The main regulators of miRNA biogenesis are the ribonucleases Drosha, Dicer and Ago2.
Olga Surova, Nadeem Shahzad Akbar, Boris Zhivotovsky   +2 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, Volume 13, Issue 47, 24 August 2026.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex

Frontiers in Neuroscience, 2018
DGCR8 and DROSHA are the minimal functional core of the Microprocessor complex essential for biogenesis of canonical microRNAs and for the processing of other RNAs. Conditional deletion of Dgcr8 and Drosha in the murine telencephalon indicated that these
Nadin Hoffmann, Stefan C. Weise, Federica Marinaro, Tanja Vogel, Davide De Pietri Tonelli   +4 more
doaj   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Expression levels of microRNA machinery components Drosha, Dicer and DGCR8 in human (AGS, HepG2, and KEYSE-30) cancer cell lines [PDF]

: MicroRNAs (miRNAs) have recently been shown to play fundamental roles in diverse cellular processes and linked to variety of cancers. Dicer and Drosha are tw major enzymes in the miRNA maturation process.
حسینی اصل, سید سعید, جعفری, ناصر, ایانگ, گلن, شیرزاد, زهره, پیری دوگاهه, هادی, علی بیکی, فاطمه, زرگر, سید جلال, بهلولی, شهاب   +7 more
core  

The RNase III Enzyme DROSHA Is Essential for MicroRNA Production and Spermatogenesis

, 2012
Background: miRNA biogenesis requires two RNase III enzymes, DROSHA and DICER. Results: Lack of DROSHA in the male germ line leads to deficiency in miRNA production and male infertility.
Small, Chris L, Yan, Wei, Song, Rui, Namekawa, Satoshi H, Ortogero, Nicole, Wu, Qiuxia, Turner, James M, Evanoff, Ryan, Zheng, Huili, Griswold, Michael D, Royo, Helene   +10 more
core   +1 more source