Results 71 to 80 of about 16,723 (215)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, Volume 16, Issue 6, Page 1222-1236, June 2026.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma [PDF]

Nature Communications, 2018
AbstractPineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients with germline mutations in DICER1, a ribonuclease involved in microRNA processing, have increased risk of pineoblastoma, but genetic drivers of sporadic pineoblastoma remain unknown ...
Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M. Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev, Stacie L. Stapleton, David Zagzag, Luis Chiriboga, Sharon L. Gardner, Jeffrey H. Wisoff, John G. Golfinos, David Capper, Volker Hovestadt, Marc K. Rosenblum, Dimitris G. Placantonakis, Sarah E. LeBoeuf, Thales Y. Papagiannakopoulos, Lukas Chavez, Sama Ahsan, Charles G. Eberhart, Stefan M. Pfister, David T. W. Jones, Matthias A. Karajannis   +28 more
openaire   +3 more sources

DROSHA targets its own transcript to modulate alternative splicing

, 2017
The nuclear RNase III enzyme DROSHA interacts with its cofactor DGCR8 to form the Microprocessor complex, which initiates microRNA (miRNA) maturation by cleaving hairpin structures embedded in primary transcripts.
Dooyoung Lee, Jin-Wu Nam, Chanseok Shin
core   +1 more source

Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy [PDF]

, 2018
Dysregulated miRNA expression and mutation of genes involved in miRNA biogenesis have been reported in motor neuron diseases including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
Brecht, Johanna, Brecht, J., Mustafa Sahin, Vilchez, David, Sahin, M., Altmüller, Janine, Laura Torres-Benito, Sahin, Mustafa, Motameny, Susanne, Hyun Ju Lee, Peters, Miriam, Kononenko, N.L., Janine Altmüller, Lee, Hyun Ju, Torres-Benito, L., Lee, H.J., Torres-Benito, Laura, Ebrahimi-Fakhari, D., Kye, Min Jeong, Vilchez, D., Brunhilde Wirth, Wirth, Brunhilde, Maximilian P. Thelen, Rehorst, Wiebke A., Inês do Carmo G. Gonçalves, Wiebke A. Rehorst, David Vilchez, Ebrahimi-Fakhari, Darius, Thelen, Maximilian P., Min Jeong Kye, Darius Ebrahimi-Fakhari, Kononenko, Natalia L., Gonçalves, I.C.G., Johanna Brecht, Miriam Peters, Rehorst, W.A., Altmüller, J., Motameny, S., Gonçalves, Inês do Carmo G., Wirth, B., Susanne Motameny, Natalia L. Kononenko, Kye, M.J., Thelen, M.P., Peters, M.   +44 more
core   +1 more source

MiRNA biogenesis. Part 1. Maturation of pre-miRNA. Maturation of canonical miRNAs

Zdorovʹe Rebenka, 2021
The scientific review presents the biogenesis of ­miRNAs. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka.
A.E. Abaturov, V.L. Babуch
doaj   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Expanding the role of Drosha to the regulation of viral gene expression [PDF]

Proceedings of the National Academy of Sciences, 2011
It is well-appreciated that viruses use host effectors for macromolecular synthesis and as regulators of viral gene expression. Viruses can encode their own regulators, but often use host-encoded factors to optimize replication. Here, we show that Drosha, an endoribonuclease best known for its role in the biogenesis of microRNAs (miRNAs), can also ...
Yao-Tang, Lin, Christopher S, Sullivan
openaire   +2 more sources

DataSheet2_Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer.XLSX

, 2022
In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Fanming Yang (11889628), Peng Li (69518), Min Hu (41912), Xiaoxiao Zhang (803510), Fanzou Liu (11889625), Qiuhuan Tian (11893079), Yan Zeng (120271)   +6 more
core   +1 more source

Exosome‐mediated miR‐4660 delivery inhibits OPN promoted hepatoma cells aggression through targeting LGALS3BP

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
miR‐4660 was found to be downregulated in exosomes derived from SMMC‐OPN cells, a stable HCC cell line that overexpresses OPN. LGALS3BP has been identified as a direct target of miR‐4660, with its expression levels elevated in both SMMC‐OPN cells and their secreted exosomes.
Cuihua Liu, Riwen An, Ting Lin, Lei Qu, Xiaopeng Zheng, Jingkun Lu, Mei Hong, Pengwei Zhao, Fangxin Zhao, Xuan Zhang   +9 more
wiley   +1 more source

HTLV-1 Tax interacts with Drosha in vitro.

, 2013
A) HeLa whole cell lysates (1 mg) were incubated with purified GST-fusion proteins (∼5 µg) bound to Glutathione-Sepharose beads: GST-Alone, GST-Tax wild type, GST-Tax N-terminus, 1–244, GST-Tax C-terminus, 244–336, and GST-Tax truncated, 288–353.
Fatah Kashanchi (45093), Elizabeth Jaworski (316459), Renaud Mahieux (149806), Aarthi Narayanan (166336), Jessica Roman (316462), Irene Guendel (173419), Anastas Popratiloff (201593), Rachel Van Duyne (83472), William Coley (316456), Zachary Klase (45089), Kylene Kehn-Hall (45085)   +10 more
core   +1 more source