Results 81 to 90 of about 17,302 (170)
MYC in Oncogenesis and Therapeutic Implications
MedComm, Volume 7, Issue 8, August 2026.The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang +5 more
wiley +1 more source
Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs
WIREs RNA, Volume 17, Issue 4, July/August 2026.NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind +2 more
wiley +1 more source
Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair
Nature Communications, 2018 The mechanism through which Drosha and Dicer affect DNA repair is not clear. Here the authors use a high-throughput approach to uncover the role of Drosha in promoting DNA:RNA hybrids at DNA damaged sites.
Wei-Ting Lu +9 more
doaj +1 more source
Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma
The FEBS Journal, Volume 293, Issue 13, Page 4043-4063, July 2026.Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris +2 more
wiley +1 more source
DROSHA targets its own transcript to modulate alternative splicing
, 2017 The nuclear RNase III enzyme DROSHA interacts with its cofactor DGCR8 to form the Microprocessor complex, which initiates microRNA (miRNA) maturation by cleaving hairpin structures embedded in primary transcripts.
Dooyoung Lee, Jin-Wu Nam, Chanseok Shin
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2012 Drosha is a key enzyme in microRNA biogenesis, generating the precursor miRNA (pre-miRNA) by excising the stem-loop embedded in the primary transcripts (pri-miRNA). The specificity for the pri-miRNAs and determination of the cleavage site are provided by
Stefanie E. Grund +4 more
doaj +1 more source
eIF4H exon 5 co-immunoprecipitates with Drosha and TN Drosha.
, 2014 (A) An immunoblot of the FLAG-tagged proteins present in the input (lanes 1–3) and bound to the anti-FLAG M2 magnetic beads (Sigma) (bound, lanes 4–6).
Mallory A. Havens (558474) +2 more
core +1 more source
Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson’s disease
, 2018 MiRNAs, a group of powerful modulator of gene expression, participate in multiple cellular processes under physiological and pathological conditions. Emerging evidence shows that Drosha, which controls the initial step in canonical miRNA biogenesis, is ...
Dayun Feng +10 more
core +1 more source
Experimental and Molecular MedicineTraumatic brain injury (TBI) is a major cause of death and disability in adults. The pathological process of TBI involves a multifactorial cascade in which kinases have been proven contribute to interactions between relevant factors and amplification of ...
Lu Huang +10 more
doaj +1 more source
Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
Nature Communications, 2017 Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular ...
Alexander C. Partin +5 more
doaj +1 more source