Results 81 to 90 of about 16,723 (215)

DataSheet1_Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer.XLSX

, 2022
In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Fanming Yang (11889628), Peng Li (69518), Min Hu (41912), Xiaoxiao Zhang (803510), Fanzou Liu (11889625), Qiuhuan Tian (11893079), Yan Zeng (120271)   +6 more
core   +1 more source

MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?

European Thyroid Journal
In recent years, germline mutations in the microRNA (miRNA) processor genes DICER1 and DGCR8 have been coupled to the development of thyroid follicular nodular disease (TFND), thereby casting new light on the etiology of this enigmatic, benign condition ...
Vincenzo Condello, C Christofer Juhlin
doaj   +1 more source

LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats

Frontiers in Cellular Neuroscience, 2018
Leucine-rich repeat kinase 2 (LRRK2) is widely expressed in the brain and exerts neurotoxicity in Parkinson’s disease. The p38/Drosha signaling activation has been reported to increase cell death under stress.
Qin Rui, Haibo Ni, Fan Gao, Baoqi Dang, Di Li, Rong Gao, Gang Chen   +6 more
doaj   +1 more source

Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery. [PDF]

PLoS ONE, 2012
The innate ability of the human cell to silence endogenous retroviruses through RNA sequences encoding microRNAs, suggests that the cellular RNAi machinery is a major means by which the host mounts a defense response against present day retroviruses ...
Rachel Van Duyne, Irene Guendel, Zachary Klase, Aarthi Narayanan, William Coley, Elizabeth Jaworski, Jessica Roman, Anastas Popratiloff, Renaud Mahieux, Kylene Kehn-Hall, Fatah Kashanchi   +10 more
doaj   +1 more source

A novel requirement for DROSHA in maintenance of mammalian CG methylation [PDF]

Nucleic Acids Research, 2017
In mammals, faithful inheritance of genomic methylation patterns ensures proper gene regulation and cell behaviour, impacting normal development and fertility. Following establishment, genomic methylation patterns are transmitted through S-phase by the maintenance methyltransferase Dnmt1.
Athanasia Stathopoulou, Jyoti B. Chhetri, John C. Ambrose, Pierre-Olivier Estève, Lexiang Ji, Hediye Erdjument-Bromage, Guoqiang Zhang, Thomas A. Neubert, Sriharsa Pradhan, Javier Herrero, Robert J. Schmitz, Steen K.T. Ooi   +11 more
openaire   +5 more sources

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

MicroRNA Biogenesis: Drosha Can't Cut It without a Partner [PDF]

Current Biology, 2005
The ribonuclease Drosha requires a dedicated double-stranded RNA binding protein to convert long, nuclear primary microRNA transcripts into shorter pre-microRNA stem-loops, the cytoplasmic precursors from which mature microRNAs are ultimately excised.
Tomari, Yukihide, Zamore, Phillip D.
openaire   +2 more sources

A constitutively active ubiquitin-proteasome pathway degrades Drosha.

, 2013
Whole cell lysates of the indicated cell types were prepared with IP Lysis Buffer (Pierce); 20 µg protein aliquots were used for western blots.
Dennis Pantazatos (451804), Sicheng Wen (162284), Dong Zheng (102852), Lynne Tucker (94927), Lulu Cao (128185), Xiaoli Tang (218589), Bharat Ramratnam (218594), Steven F. Moss (162308)   +7 more
core   +1 more source

DNA methylation directs microRNA biogenesis in mammalian cells

Nature Communications, 2019
Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA ...
Ohad Glaich, Shivang Parikh, Rachel E. Bell, Keren Mekahel, Maya Donyo, Yodfat Leader, Ronna Shayevitch, Danna Sheinboim, Sivan Yannai, Dror Hollander, Ze’ev Melamed, Galit Lev-Maor, Gil Ast, Carmit Levy   +13 more
doaj   +1 more source

Knock-down of core proteins regulating microRNA biogenesis has no effect on sensitivity of lung cancer cells to ionizing radiation. [PDF]

PLoS ONE, 2012
Recent studies underline the important role of microRNAs (miRNA) in the development of lung cancer. The main regulators of miRNA biogenesis are the ribonucleases Drosha, Dicer and Ago2.
Olga Surova, Nadeem Shahzad Akbar, Boris Zhivotovsky   +2 more
doaj   +1 more source