Results 61 to 70 of about 16,723 (215)

DataSheet5_Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer.XLS

, 2022
In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Fanming Yang (11889628), Peng Li (69518), Min Hu (41912), Xiaoxiao Zhang (803510), Fanzou Liu (11889625), Qiuhuan Tian (11893079), Yan Zeng (120271)   +6 more
core   +1 more source

Glycogen synthase kinase 3 beta (GSK3β) phosphorylates the RNAase III enzyme Drosha at S300 and S302. [PDF]

PLoS ONE, 2011
The canonical microRNA (miRNA) pathway commences with the enzymatic cleavage of the primary gene transcript (pri-miRNA) by the RNAase III enzyme Drosha in the nucleus into shorter pre-miRNA species that are subsequently exported to the cytoplasm for ...
Xiaoli Tang, Ming Li, Lynne Tucker, Bharat Ramratnam   +3 more
doaj   +1 more source

ECM Substrates Impact RNAi Localization at Adherens Junctions of Colon Epithelial Cells

Cells, 2022
The extracellular matrix (ECM) plays crucial roles in tissue homeostasis. Abnormalities in ECM composition are associated with pathological conditions, such as fibrosis and cancer.
Amanda C. Daulagala, Antonis Kourtidis
doaj   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, EarlyView.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

DataSheet4_Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer.XLS

, 2022
In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and influence its
Fanming Yang (11889628), Peng Li (69518), Min Hu (41912), Xiaoxiao Zhang (803510), Fanzou Liu (11889625), Qiuhuan Tian (11893079), Yan Zeng (120271)   +6 more
core   +1 more source

Transcription factor binding sites are highly enriched within microRNA precursor sequences

Biology Direct, 2011
Background Transcription factors are thought to regulate the transcription of microRNA genes in a manner similar to that of protein-coding genes; that is, by binding to conventional transcription factor binding site DNA sequences located in or near ...
Piriyapongsa Jittima, Jordan I King, Conley Andrew B, Ronan Tom, Smalheiser Neil R   +4 more
doaj   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, Volume 293, Issue 13, Page 4043-4063, July 2026.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Disruption of Drosha in VSMCs results in embryonic mortality.

, 2013
A. Morphology of Drosha cKO (Droshaloxp/loxp/SM22-Cre) and control (Droshaloxp/loxp) embryos at E13.5 and E14.5. B. Vasculature of yolk sac in control and Drosha cKO mice between E13.5 and E14.5. C.
Zixuan Chen (404126), Yan Jiao (308467), Junming Yue (87896), Yan Cui (9885), Yi Xue (404127), Yuqi Guo (404129), Anindya Bhattacharya (127895), Jianmin Wu (19537), Weiwang Gu (351700), Meifen Lu (404128), Weikuan Gu (308468), Peng Tian (119465), Wen Liu (39804), Pei Fan (404125)   +13 more
core   +1 more source

miRNA Sensor HuR Compartmentalizes Ago2‐Uncoupled miRNAs to Lipid Droplets to Buffer miRNA Activity in Mammalian Cells

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
This study revealed a dose‐dependent miRNA buffering mechanism involving extracellular export and storage of miRNA on lipid droplets. The protein HuR facilitates miRNA buffering by dissociating miRNAs from Ago2 and promoting miRNA accumulation on lipid droplets or its extracellular export, depending on cellular requirements.
Sreemoyee Chakraborty, Diptankar Bandyopadhyay, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +3 more
wiley   +1 more source

A multifunctional protein EWS regulates the expression of Drosha and microRNAs [PDF]

Cell Death & Differentiation, 2013
EWS (Ewing's Sarcoma) gene encodes an RNA/DNA-binding protein that is ubiquitously expressed and involved in various cellular processes. EWS deficiency leads to impaired development and early senescence through unknown mechanisms. We found that EWS regulates the expression of Drosha and microRNAs (miRNAs).
K Y, Kim, Y J, Hwang, M-K, Jung, J, Choe, Y, Kim, S, Kim, C-J, Lee, H, Ahn, J, Lee, N W, Kowall, Y K, Kim, J-I, Kim, S B, Lee, H, Ryu   +13 more
openaire   +2 more sources