Results 61 to 70 of about 17,302 (170)

Understanding Recognition of Primary MicroRNAs by Human Drosha/DGCR8

, 2020
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by suppressing messenger RNAs. The RNase Drosha, as part of the Microprocessor complex, performs the initial processing step in miRNA biogenesis.
Partin, Alexander Christian
core   +1 more source

MicroRNA‐Mediated Autophagy and Cardiovascular Diseases: Exploring the Crossroads of Atherosclerosis and Beyond

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi, Amir Hossein Barjasteh, Aida Zarei, Sina Bazmi, Sarah Vaseghi, Sara Ashna, Amirreza Solati, Ali Yousefzadeh, Bita Safarzadeh Nasrabad, Zahra Mohammadi, Hamed Haddad Kashani, Mohammad Hossein Pourhanifeh   +11 more
wiley   +1 more source

Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB [PDF]

, 2016
Adult neural stem cells (NSCs) are defined by their inherent capacity to self-renew and give rise to neurons, astrocytes, and oligodendrocytes. In vivo, however, hippocampal NSCs do not generate oligodendrocytes for reasons that have remained enigmatic ...
Erni, A., Gokhale, P.J., Beattie, R., Rolando, Chiara, Grison, Alice, Taylor V, Erni, Andrea, Milo, M., Erni A, Beattie R, Gokhale, P. J., Taylor, V., Milo, Marta, Grison A, Jessberger, Sebastian, Jessberger, S., Wegleiter, Thomas, Wegleiter, T., Taylor, Verdon, Engler, Anna, Rolando, C., Jessberger S, Wegleiter T, Gokhale PJ, Milo M, Gokhale, Paul J, Rolando C, Grison, A., Beattie, Robert, Engler, A., Engler A   +30 more
core   +1 more source

MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?

European Thyroid Journal
In recent years, germline mutations in the microRNA (miRNA) processor genes DICER1 and DGCR8 have been coupled to the development of thyroid follicular nodular disease (TFND), thereby casting new light on the etiology of this enigmatic, benign condition ...
Vincenzo Condello, C Christofer Juhlin
doaj   +1 more source

MicroRNA‐Mediated Placental Maladaptation in Preeclampsia Pathogenesis

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Graphical representation of miRNA‐mediated placental maladaptation in preeclampsia. Under normal pregnancy conditions, balanced expression of beneficial miRNAs (miR‐126‐3p, miR‐18a/b‐5p, miR‐144‐3p, miR‐378a‐5p, and miR‐146a‐5p) promotes trophoblast proliferation, migration and invasion, spiral artery remodeling, angiogenesis, mitochondrial function ...
Sarbani Saha, Rupasri Ain
wiley   +1 more source

The Drosha-DGCR8 complex in primary microRNA processing

, 2004
RNase III proteins play key roles in microRNA (miRNA) biogenesis. The nuclear RNase III Drosha cleaves primary miRNAs (pri-miRNAs) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic RNase III Dicer to generate mature miRNAs.
Yeom, Kyu-Hyun, Han, JJ, Kim, YK, Kyu-hyun Yeom, Kim, V. Narry, Jin, H, Young-kook Kim, Jin, Hua, Yeom, KH, V. Narry Kim, Han, Jin Ju, Kim, Young-Kook, Hua Jin, Kim, VN, Yoontae Lee, Lee, Y, Jinju Han, Lee, Yoontae   +17 more
core   +1 more source

LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats

Frontiers in Cellular Neuroscience, 2018
Leucine-rich repeat kinase 2 (LRRK2) is widely expressed in the brain and exerts neurotoxicity in Parkinson’s disease. The p38/Drosha signaling activation has been reported to increase cell death under stress.
Qin Rui, Haibo Ni, Fan Gao, Baoqi Dang, Di Li, Rong Gao, Gang Chen   +6 more
doaj   +1 more source

Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery. [PDF]

PLoS ONE, 2012
The innate ability of the human cell to silence endogenous retroviruses through RNA sequences encoding microRNAs, suggests that the cellular RNAi machinery is a major means by which the host mounts a defense response against present day retroviruses ...
Rachel Van Duyne, Irene Guendel, Zachary Klase, Aarthi Narayanan, William Coley, Elizabeth Jaworski, Jessica Roman, Anastas Popratiloff, Renaud Mahieux, Kylene Kehn-Hall, Fatah Kashanchi   +10 more
doaj   +1 more source

MicroRNA‐Driven Regulation of β‐Cell Function in Type 2 Diabetes: Molecular Mechanisms, Network Insights, and Translational Perspectives

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β‐cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β‐cell compensation and progressive secretory dysfunction.
Lena Eliasson, Alexandros Karagiannopoulos, Mototsugu Nagao, Anna Wendt   +3 more
wiley   +1 more source

HTLV-1 Tax interacts with Drosha in vitro.

, 2013
A) HeLa whole cell lysates (1 mg) were incubated with purified GST-fusion proteins (∼5 µg) bound to Glutathione-Sepharose beads: GST-Alone, GST-Tax wild type, GST-Tax N-terminus, 1–244, GST-Tax C-terminus, 244–336, and GST-Tax truncated, 288–353.
Fatah Kashanchi (45093), Elizabeth Jaworski (316459), Renaud Mahieux (149806), Aarthi Narayanan (166336), Jessica Roman (316462), Irene Guendel (173419), Anastas Popratiloff (201593), Rachel Van Duyne (83472), William Coley (316456), Zachary Klase (45089), Kylene Kehn-Hall (45085)   +10 more
core   +1 more source