Results 101 to 110 of about 16,723 (215)

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Rare Drosha Splice Variants Are Deficient in MicroRNA Processing but Do Not Affect General MicroRNA Expression in Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2012
Drosha is a key enzyme in microRNA biogenesis, generating the precursor miRNA (pre-miRNA) by excising the stem-loop embedded in the primary transcripts (pri-miRNA). The specificity for the pri-miRNAs and determination of the cleavage site are provided by
Stefanie E. Grund, Maria Polycarpou-Schwarz, Chonglin Luo, Stefan B. Eichmüller, Sven Diederichs   +4 more
doaj   +1 more source

Systemic microRNA profiles associated with coronary plaque stability and clinical phenotypes in patients with coronary artery disease

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
This study identifies circulating microRNAs associated with plaque destabilization in cardiovascular disease, highlighting their potential as non‐invasive biomarkers and therapeutic targets. Abstract Background The development of coronary artery disease (CAD) and plaque destabilization are caused by endothelial dysfunction, inflammation and hypoxia ...
Souhir Wassaifi, Nadia Rahali, Josef Finsterer, Dhaker Lahidheb, Bertrand Kaeffer, Sinda Zarrouk   +5 more
wiley   +1 more source

The N-terminus of Drosha is responsible for regulating its degradation.

, 2013
HEK293T cells were transfected with an empty vector, GFP-Drosha wild type or the various mutants as indicated. Forty-eight hours post-transfection, whole cell lysates were prepared for western blot. GAPDH was used as a loading control.
Dennis Pantazatos (451804), Sicheng Wen (162284), Dong Zheng (102852), Lynne Tucker (94927), Lulu Cao (128185), Xiaoli Tang (218589), Bharat Ramratnam (218594), Steven F. Moss (162308)   +7 more
core   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for histopathology

Histopathology, Volume 88, Issue 7, Page 1291-1294, June 2026.
Ian A Cree, Mark J Arends, Joseph D Khoury, Erika RE Denton, Anthony J Gill, Alexander J Lazar, Ian M Frayling, Stefan M Pfister, Mark A Rubin, Katia RM Leite, Raymond Dalgleish, Elspeth A Bruford, Sharon Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

Maintaining Drosha expression with Cdk5 inhibitors as a potential therapeutic strategy for early intervention after TBI

Experimental and Molecular Medicine
Traumatic brain injury (TBI) is a major cause of death and disability in adults. The pathological process of TBI involves a multifactorial cascade in which kinases have been proven contribute to interactions between relevant factors and amplification of ...
Lu Huang, Li Xia, Tiejian Nie, Bozhou Cui, Jianjun Lu, Fangfang Lu, Feiyan Fan, Dongni Ren, Yuan Lu, Guodong Gao, Qian Yang   +10 more
doaj   +1 more source

Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

Nature Communications, 2017
Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular ...
Alexander C. Partin, Tri D. Ngo, Emily Herrell, Byung-Cheon Jeong, Gary Hon, Yunsun Nam   +5 more
doaj   +1 more source

Genetic variants in microRNA machinery genes are associated [corrected] with idiopathic recurrent pregnancy loss risk.

PLoS ONE, 2014
ObjectiveKey molecules involved in microRNA (miRNA) biogenesis, such as DROSHA, XPO5, and DICER, have been identified in trophoblast cells, confirming that the miRNA biogenesis pathway is active in human placenta.
Yong Wook Jung, Young Joo Jeon, HyungChul Rah, Ji Hyang Kim, Ji Eun Shin, Dong Hee Choi, Sun Hee Cha, Nam Keun Kim   +7 more
doaj   +1 more source

The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder

, 2022
DROSHA encodes a ribonuclease that is a subunit of the Microprocessor complex and is involved in the first step of microRNA (miRNA) biogenesis. To date, DROSHA has not yet been associated with a Mendelian disease.
Jasien, Joan, Lopergolo, Diego, Undiagnosed Diseases Network, Shashi, Vandana, Telischi, Fred, Grajewski, Alana, Network, Undiagnosed Diseases, Sacco, Ralph, McCauley, Jacob, Bademci, Guney, Mikati, Mohamad A., Kansagra, Sujay, Ariani, Francesca, Barbouth, Deborah, Jiang, Yong-Hui, Bellen, Hugo J., Zuchner, Stephan, Minogue, Amanda L., Liu, Xue, Stong, Nicholas, Lam, Byron, Barish, Scott, Senturk, Mumine, Chang, Ta, Wangler, Michael F., Saporta, Mario, Renieri, Alessandra, Kranz, Peter G., Tekin, Mustafa, Schoch, Kelly, Arur, Swathi, Harland, Jake, Seemann, Jacob H., Fallerini, Chiara, Mari, Francesca, El-Dairi, Mays, Galluzzi, Paolo, Carrasquillo, Olveen, Yamamoto, Shinya, Levitt, Roy, Isasi, Rosario   +40 more
core   +1 more source