Results 111 to 120 of about 16,723 (215)

Post-transcriptional regulation of neural stem cell fate by the RNaseIII Drosha [PDF]

, 2017
Stem cells are found in several organs where they are committed to differentiate into tissue specific somatic cells. In the developing and adult mammalian brain neural stem cells (NSCs) have the ability to differentiate into different cell types, the ...
Erni, Andrea
core   +1 more source

The RNase III Enzyme DROSHA Is Essential for MicroRNA Production and Spermatogenesis

, 2012
Background: miRNA biogenesis requires two RNase III enzymes, DROSHA and DICER. Results: Lack of DROSHA in the male germ line leads to deficiency in miRNA production and male infertility.
Small, Chris L, Yan, Wei, Song, Rui, Namekawa, Satoshi H, Ortogero, Nicole, Wu, Qiuxia, Turner, James M, Evanoff, Ryan, Zheng, Huili, Griswold, Michael D, Royo, Helene   +10 more
core   +1 more source

Expression, Covariation, and Genetic Regulation of miRNA Biogenesis Genes in Brain Supports their Role in Addiction, Psychiatric Disorders, and Disease

Frontiers in Genetics, 2013
The role of miRNA and miRNA biogenesis genes in the adult brain is just beginning to be explored. In this study we have performed a comprehensive analysis of the expression, genetic regulation, and co-expression of major components of the miRNA ...
Megan Kathleen Mulligan, Candice eDuBose, Junming eYue, Michael F. Miles, Lu eLu, Lu eLu, Kristin M Hamre   +6 more
doaj   +1 more source

Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition. [PDF]

Clin Cancer Res
Purpose: DROSHA, DGCR8, and DICER1 regulate miRNA biogenesis and are commonly mutated in cancer. Although DGCR8 and DICER1 germline pathogenic variants (GPV) cause autosomal dominant tumor predisposition, no association between DROSHA GPVs and clinical ...
Fiorica PN, Golmard L, Kim J, Bao R, Lin FY, Roy A, Pribnow A, Perrino MR, Masliah-Planchon J, Michalak-Provost S, Wong J, Filser M, Stoppa-Lyonnet D, Bourdeaut F, Brahimi A, Ingster O, Saulnier Sholler G, Jackson SA, Sasaki MM, Fowler T, Ng A, Corbett RJ, Kaufman RS, Haley JS, Carey DJ, Huang KL, Diskin SJ, Rokita JL, Al-Kateb H, McGee RB, Schiffman JD, Chen KS, Stewart DR, Williams Parsons D, Plon SE, Schultz KAP, Onel K.   +36 more
europepmc   +2 more sources

Immunolocalization of a Drosha-Like Protein in Tetrahymena thermophila

, 2021
Drosha is an enzyme used by animals to process pri-miRNA into pre-miRNA. This processing normally occurs in the nucleus. The partly processed RNA molecule is then exported to the cytosol, where it is fully processed and then used in gene regulation ...
Cox, Emily, Kuruvilla, Heather G., Weidensee, Joanna M., Gibson, Joanna L.   +3 more
core  

Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas

International Journal of Genomics, 2017
Aberrant regulation of microRNA (miRNA) machinery components is associated with various human cancers, including papillary thyroid carcinoma (PTC), which is the most common type of thyroid cancer, and a higher prevalent female malignancy.
Jaegil Kim, Woo-Jae Park, Kwang-Joon Jeong, Sun Hee Kang, Sun Young Kwon, Shin Kim, Jong-Wook Park   +6 more
doaj   +1 more source

Interdependence of Pasha and Drosha for localization and function of the Microprocessor in C. elegans

Nature Communications
Primary microRNA (pri-miRNA) transcripts are processed by the Microprocessor, containing the ribonuclease Drosha and its RNA-binding partner DGCR8/Pasha. In a forward genetic screen utilizing a fluorescence-based sensor that monitors pri-miRNA processing
Thiago L. Knittel, Brooke E. Montgomery, Kailee J. Reed, Madeleine C. Chong, Ida J. Isolehto, Erin R. Cafferty, Margaret J. Smith, Reese A. Sprister, Colin N. Magelky, Hataichanok Scherman, René F. Ketting, Taiowa A. Montgomery   +11 more
doaj   +1 more source

Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Frontiers in Immunology, 2018
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer.
Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P. A. MacDonald, Bruce R. Blazar   +4 more
doaj   +1 more source

The Human ARF Tumor Suppressor Regulates Drosha Nucleolar Localization and rRNA Processing Activity

, 2016
Ribosomes are vital to the survival of a cell, as they are directly responsible for the synthesis of proteins, which perform critical cellular functions.
Yaddanapudi, Sree Chandana Sridhar
core   +1 more source

Non-canonical RNA substrates of Drosha lack many of the conserved features found in primary microRNA stem-loops

Scientific Reports
The RNase III enzyme Drosha has a central role in microRNA (miRNA) biogenesis, where it is required to release the stem-loop intermediate from primary (pri)-miRNA transcripts. However, it can also cleave stem-loops embedded within messenger (m)RNAs. This
Karen Gu, Lawrence Mok, Matthew J. Wakefield, Mark M. W. Chong   +3 more
doaj   +1 more source