Results 121 to 130 of about 16,723 (215)

Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson’s disease

, 2018
MiRNAs, a group of powerful modulator of gene expression, participate in multiple cellular processes under physiological and pathological conditions. Emerging evidence shows that Drosha, which controls the initial step in canonical miRNA biogenesis, is ...
Dayun Feng, Kai Tao, Zixu Mao, Gang Zhu, Shaosong Yang, Lu Huang, Qian Yang, Fangfang Lu, Ronglin Wang, Tiejian Nie, Jie Lei   +10 more
core   +1 more source

Study of the association between Dicer (rs3742330 A>G) and Drosha (rs10719 C>T) gene polymorphisms and the risk of recurrent pregnancy loss

Fiyz̤, 2018
Background: Drosha and Dicer are important molecules that play critical regulatory roles in the biogenesis of micro-RNA. Genetic polymorphism in the Drosha and Dicer can cause defect on the embryo implantation and lead to the recurrent abortion.
Negin Mohseni , Saeid Ghorbian
doaj  

DROSHA associates to DNA damage sites and is required for DNA repair

, 2018
The DNA damage response (DDR) is the signaling cascade through which a cell recognizes DNA lesions, and promotes their resolution via the repair pathways of Non-Homologous End Joining (NHEJ), or Homologous Recombination (HR).
Lina Cipolla, Fabrizio d’Adda di Fagagna, Alessandro Galbiati, Marco Roncador, Fabio Iannelli, Matteo Cabrini, Simone Sabbioneda, Sofia Francia   +7 more
core   +1 more source

Analysis of MicroRNA Processing Machinery Gene DROSHA, DICER1, and XPO5 Variants Association with Atherosclerosis: A Case–control Study

Biomedical and Biotechnology Research Journal
Background: Atherosclerosis, a primary cause of coronary artery disease, involves chronic inflammatory arterial changes and contributes significantly to global vascular mortality.
Manar F. Atoum, Dalya Alowaisy, Ammar Ali Deeb   +2 more
doaj   +1 more source

eIF4H exon 5 co-immunoprecipitates with Drosha and TN Drosha.

, 2014
(A) An immunoblot of the FLAG-tagged proteins present in the input (lanes 1–3) and bound to the anti-FLAG M2 magnetic beads (Sigma) (bound, lanes 4–6).
Mallory A. Havens (558474), Ashley A. Reich (558475), Michelle L. Hastings (31169)   +2 more
core   +1 more source

DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor.

Wilms tumor, the most common pediatric kidney cancer, resembles embryonic renal progenitors. Currently, there are no ways to therapeutically target Wilms tumor driver mutations, such as in the microRNA processing gene DROSHA.
Tiburcio, PDB, Kim, J, Zhou, Q, Desai, K, Xu, L, Chen, KS, Guo, L, Catchpoole, DR, Xiao, X, Zhou, L, Yuksel, A, Amatruda, JF   +11 more
core   +1 more source

DROSHA compromised HCT116 cells are resistant to ER stress-induced cell death.

, 2013
A) QRT-PCR for Drosha in HCT116 WT, and DROSHA shRNA cells, with or without 500 ng/ml of Doxycycline. B) QRT-PCR for Pri-miRNA-17 WT and DROSHA shRNA cells with Doxycycline for three days. C) QRT-PCR for miRNA in WT and DROSHA shRNA cells with or without
Susan E. Logue (447410), Adrienne M. Gorman (447411), Afshin Samali (161678), Qingping Zeng (447412), Sanjeev Gupta (161674), John Patterson (447413), Karen Cawley (447409)   +6 more
core   +1 more source

DROSHA Gene [PDF]

, 2020
openaire   +1 more source

Drosha in mesangial cells regulates Glomerular Capillary Tufts Formation Through Drosha/Ribosome/Gata3 Axis

Abstract Drosha is a critical regulator of kidney development; its loss or mutation, identified in a subsets of Wilms tumor (WT), a pediatric kidney cancer, leads to nephric cap mesenchyme developmental defects. Here, we investigated the role of Drosha in mesangial cells and its impact on glomerular capillary tuft formation.
Jin Tang, Lang Qin, Jiajia Qin, Zixuan Fan, Tingxuan Xu, Wenjun Xiao, Yonghui He, Xin Li, Zhenbo Yuan, Weiqian Chen, Chuwen Lin, Xuan Jiang   +11 more
openaire   +1 more source

Drosha Expression and Microprocessor Activity in Maturing Bovine Oocytes and Cultured Granulosa Cells

, 2021
This thesis investigates localization and expression of RNA-binding protein Drosha within maturing bovine oocytes, and the effect of experimentally inhibiting Drosha on processing several microRNA precursors into mature forms in cumulus cells (CCs ...
Stuart, Deirdre
core