Results 31 to 40 of about 34,642 (262)
A role for Dicer in immune regulation [PDF]
The Journal of Cell Biology, 2006 Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells.
Cobb, BS +10 more
openaire +6 more sources
Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients
BMC Cancer, 2011 Background Dicer is aberrantly expressed in several types of cancers. Applying real-time PCR, we detected the expression of Dicer mRNA in normal mucosa (n = 162), primary colorectal cancer (CRC) (n = 162) and liver metastasis (n = 37), and analysed the ...
Sun Xiao-Feng +6 more
doaj +1 more source
Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes. [PDF]
PLoS ONE, 2013 Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and post-transcriptional level suggesting the role of microRNA (miRNA) and double-stranded RNA ...
Yuanqing Yan +9 more
doaj +1 more source
eLife, 2023 Antiviral defense in ecdysozoan invertebrates requires Dicer with a helicase domain capable of ATP hydrolysis. But despite well-conserved ATPase motifs, human Dicer is incapable of ATP hydrolysis, consistent with a muted role in antiviral defense.
Adedeji M Aderounmu +3 more
doaj +1 more source
Journal of International Medical Research, 2021 Objective This study explored the functional interactions between the long non-coding RNA DICER-AS1 and the cellular stress response 1 ( CSR1 ) gene in gastric cancer.
Junyan An, Xiaoling Guo, Bingli Yan
doaj +1 more source
MicroRNA processing without Dicer [PDF]
Genome Biology, 2010 The canonical processing of precursor microRNAs requires the endonuclease Dicer. A recent study shows that microRNAs can be processed independently of Dicer but instead require Argonaute 2.
Dueck, A., Meister, G.
openaire +3 more sources
Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice.
PLoS ONE, 2014 Dicer is required for the maturation of microRNA, and loss of Dicer and miRNA processing has been found to alter numerous biological events during embryogenesis, including the development of mammalian skin and hair.
Stephen Lyle +5 more
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
The evolution and diversification of Dicers in plants [PDF]
FEBS Letters, 2006 Most multicellular organisms regulate developmental transitions by microRNAs, which are generated by an enzyme, Dicer. Insects and fungi have two Dicer‐like genes, and many animals have only one, yet the plant, Arabidopsis, has four. Examining the poplar and rice genomes revealed that they contain five and six Dicer‐like genes, respectively.
Margis, Rogerio +6 more
openaire +3 more sources
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source