Results 31 to 40 of about 41,308 (256)

The role of Dicer protein partners in the processing of microRNA precursors.

PLoS ONE, 2011
One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP.
Edyta Koscianska, Julia Starega-Roslan, Wlodzimierz J Krzyzosiak   +2 more
doaj   +1 more source

Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects

Molecular Metabolism, 2019
Objective: Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we aimed to specifically test which missing dietary component was responsible for DICER ...
Beatriz A. Guerra, Bruna B. Brandão, Silas S. Pinto, Willian G. Salgueiro, Evandro A. De-Souza, Felipe C.G. Reis, Thiago M. Batista, Vanessa Cavalcante-Silva, Vânia D'Almeida, Beatriz A. Castilho, Everardo M. Carneiro, Adam Antebi, William T. Festuccia, Marcelo A. Mori   +13 more
doaj   +1 more source

CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background CyclinD1 is crucial for cell cycling and can regulate the expression of Dicer, a crucial regulator of microRNA maturation. However, little is known on how CyclinD1 regulates Dicer and miRNA expression, and the progression of intrahepatic ...
Yongqiang Qi, Da Wang, Wenhua Huang, Bing Wang, Di Huang, Fei Xiong, Xiaoping Chen, Yongjun Chen   +7 more
doaj   +1 more source

Tendon-Specific Dicer Deficient Mice Exhibit Hypoplastic Tendon Through the Downregulation of Tendon-Related Genes and MicroRNAs

Frontiers in Cell and Developmental Biology, 2022
Tendon is a fibrous connective tissue, that is, transmitting the forces that permit body movement. However, tendon/ligament biology is still not fully understood and especially, the role of miRNAs in tendon/ligament is sparse and uncharacterized in in ...
Takenori Omoto, Dilimulati Yimiti, Yohei Sanada, Yohei Sanada, Minoru Toriyama, Chenyang Ding, Yuta Hayashi, Yuta Hayashi, Yasunari Ikuta, Tomoyuki Nakasa, Tomoyuki Nakasa, Masakazu Ishikawa, Masakazu Ishikawa, Masayuki Sano, Minjung Lee, Takayuki Akimoto, Chisa Shukunami, Shigeru Miyaki, Shigeru Miyaki, Nobuo Adachi   +19 more
doaj   +1 more source

Leica SP5 files FH-Dicer

, 2016
<p>This file contains all the Leica SP5 confocal images as well as an index file for the manuscript 'Endogenous mouse Dicer is an exclusively cytoplasmic protein' submitted to PLOS Genetics.</p ...
Much, Christian (5288515), O'Carroll, Donal (5288512), Much, Christian, O'Carroll, Donal   +3 more
core   +1 more source

Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients

BMC Cancer, 2011
Background Dicer is aberrantly expressed in several types of cancers. Applying real-time PCR, we detected the expression of Dicer mRNA in normal mucosa (n = 162), primary colorectal cancer (CRC) (n = 162) and liver metastasis (n = 37), and analysed the ...
Sun Xiao-Feng, Hinselwood David, Wallin Åsa, Gnosa Sebastian, Wang Chao-Jie, Stratmann Johannes, Zhang Hong   +6 more
doaj   +1 more source

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer [PDF]

Open Biology, 2013
The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA ...
Timothy M. Johanson, Andrew M. Lew, Mark M. W. Chong   +2 more
doaj   +1 more source

Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function

eLife, 2023
Antiviral defense in ecdysozoan invertebrates requires Dicer with a helicase domain capable of ATP hydrolysis. But despite well-conserved ATPase motifs, human Dicer is incapable of ATP hydrolysis, consistent with a muted role in antiviral defense.
Adedeji M Aderounmu, P Joseph Aruscavage, Bryan Kolaczkowski, Brenda L Bass   +3 more
doaj   +1 more source

Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice.

PLoS ONE, 2014
Dicer is required for the maturation of microRNA, and loss of Dicer and miRNA processing has been found to alter numerous biological events during embryogenesis, including the development of mammalian skin and hair.
Stephen Lyle, Kathleen Hoover, Cansu Colpan, Zhiqing Zhu, Zdenka Matijasevic, Stephen N Jones   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source