Results 131 to 140 of about 1,558,397 (364)

The EU Directive on Free Movement - A Challenge for the European Welfare State? [PDF]

Freizügigkeit, Niederlassungsrecht, EU-Recht, Sozialstaat, Europäische Wirtschafts- und Währungsunion, Freedom of movement, Freedom of establishment, Community law, Welfare state, European Economic and Monetary ...
Wolfgang Ochel
core  

From the Bernoulli Factory to a Dice Enterprise via Perfect Sampling of Markov Chains [PDF]

, 2019
Giulio Morina, Latuszynski, Krzysztof, Piotr Nayar, Alex Wendland   +3 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Diversity in Shareholder Protection in Common Law Countries [PDF]

Aktionär, Anlegerschutz, Common Law, Shareholders, Investor ...
Mathias M. Siems, Priya P. Lele
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Fiscal effects of cannabis legalisation

Wirtschaftsdienst, 2021
Justus Haucap, Leon Knoke
doaj   +1 more source

L’autoritarisme du verdissement hydroélectrique au Panama : les paradoxes dérégulateurs de l’action climatique vus depuis le Sud

Lien Social et Politiques, 2019
Cet article interroge les effets dérégulateurs du Mécanisme de développement propre (MDP). Créé en 2001 par les Nations Unies, ce mécanisme incite les pays industrialisés soumis à des objectifs de réduction d’émissions de gaz à effet de serre dans le ...
Marie-Esther Lacuisse
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Storable Votes: Giving Voice to Minority Preferences without Sacrificing Efficiency [PDF]

Wahlverhalten, Wahlsystem, Minderheit, Politische Partei, Voting behaviour, Electoral system, Minority, Political ...
Alessandra Casella, Raymond Riezman, Thomas Palfrey   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source