Results 201 to 210 of about 134,287 (354)

DG-TTA: Out-of-Domain Medical Image Segmentation Through Augmentation, Descriptor-Driven Domain Generalization, and Test-Time Adaptation. [PDF]

Sensors (Basel)
Weihsbach C, Kruse CN, Bigalke A, Heinrich MP.   +3 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Sustainable deep learning-based breast lesion segmentation: impact of breast region segmentation on performance. [PDF]

BMC Med Imaging
Narimani S, Hoff SR, Kurz KD, Gjesdal KI, Geisler J, Grøvik E.   +5 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

H-fusion SEG: dual-branch hyper-attention fusion network with SAM integration for robust skin disease segmentation. [PDF]

Sci Rep
El-Shafai W, Ali AM, Alzaben N, El-Fattah IA.   +3 more
europepmc   +1 more source

Entre le visible et le dicible : l’art du portrait chez Julien Green

, 2000
Dominique Van Hooff
openalex   +1 more source

Diorganotin dications stabilized by neutral ligands in the solid state: [R2Sn(H2O)2(OPPh3)2](O3SCF3)2 (R = Me, Bu) [PDF]

, 2003
Jens Beckmann, Dainis Dakternieks, Andrew Duthie, Cassandra Mitchell   +3 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

An open deep learning-based framework and model for tooth instance segmentation in dental CBCT. [PDF]

Clin Oral Investig
Zhou Y, Xu Y, Khalil B, Nalley A, Tarce M.   +4 more
europepmc   +1 more source

The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer [PDF]

, 2003
Vaishali Handa
openalex   +1 more source