Results 271 to 280 of about 134,287 (354)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Automated AI-based segmentation of canine hepatic focal lesions from CT studies. [PDF]

Front Vet Sci
Burti S, Jurgas A, Puccinelli C, Cherubini GB, Citi S, Zotti A, Wodziniski M, Brusco R, Quaresima E, Giordano M, Bendazzoli M, Wilson D, Mastromattei N, Banzato T.   +13 more
europepmc   +1 more source

¿Qué dices tú, hoy, de la democracia en la escuela? [PDF]

, 2003
Ángels Martínez
openalex  

Dicing Process for Thin Silicon Wafer by Using Femtosecond-laser

, 2004
Takafumi Ninomiya, Hiroshi Sawada, Kosuke Kawahara, Atsushi Yokotani, Kou Kurosawa   +4 more
openalex   +2 more sources

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

MDWC-Net: a multi-scale dynamic-weighting context network for precise spinal X-ray segmentation. [PDF]

Front Physiol
Gu Z, Wang X, Chen B.
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Full-head segmentation of MRI with abnormal brain anatomy: model and data release. [PDF]

J Med Imaging (Bellingham)
Birnbaum AM, Buchwald A, Turkeltaub P, Jacks A, Carr G, Kannan S, Huang Y, Datta A, Parra LC, Hirsch LA.   +9 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source