Results 271 to 280 of about 1,558,397 (364)

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Prompt-Driven Multimodal Segmentation with Dynamic Fusion for Adaptive and Robust Medical Imaging with Applications to Cancer Diagnosis. [PDF]

Cancers (Basel)
Alsaedi SA, Balaha HM, Farsi M, Alwateer M, Aboelnaga MM, Shehata M, Badawy M, Elhosseini MA.   +7 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Biostatistics - A Tool for Improving Clinical Decisions

Apollo Medicine, 2005
Umesh Gupta, Hema Lal, Pritindira , Anupam Sibal   +3 more
doaj   +1 more source

Gross-tumor-volume segment-anything model for medical 2D images integrating gross tumor volume-minimal feature integration technology for lung cancer segmentation. [PDF]

Quant Imaging Med Surg
Yi C, Li Y, Cao S, Xiong Q, Jiang S, Zhang H.   +5 more
europepmc   +1 more source

Splicing and dicing with a SERRATE d edge

, 2008
Taiowa A. Montgomery, James C. Carrington   +1 more
openalex   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Unpacking trends in “deaths of despair” in a cohort of male mine workers: A commentary on Colbeth et al., 2024

SSM - Mental Health
Ana Lucia Espinosa Dice
doaj   +1 more source

CoreFormer high fidelity pulmonary nodule segmentation with structural core priors and geodesic implicit fields. [PDF]

NPJ Digit Med
Xi Y, Xu C, Ye F, Yuan M, Ye C, Jiang L, Huang Y, Zhang J, Liu M, Liu X, Yu B.   +10 more
europepmc   +1 more source