Results 121 to 130 of about 77,494 (336)
High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2 [PDF]
, 2018 Myotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by abnormally expanded stretches of CTG DNA triplets in the DMPK gene, leading to mutated-transcript RNA-toxicity.
Cappella, Marisa +11 more
core +2 more sources
Advanced Science, EarlyView.vEMINR is an ultra‐fast isotropic reconstruction method for vEM based on implicit neural representation, achieving over tenfold faster reconstruction and higher accuracy on 11 datasets, showing strong potential for large‐scale vEM data processing.
Jibin Yang +7 more
wiley +1 more source
Key Enzymes and Proteins of Crop Insects as Candidate for RNAi Based Gene Silencing
Frontiers in Physiology, 2015 RNA interference (RNAi) is a mechanism of homology dependent gene silencing present in plants and animals. It operates through 21-24 nucleotides small RNAs which are processed through a set of core enzymatic machinery that involves Dicer and Argonaute ...
Vijaya Sudhakara Rao K +3 more
doaj +1 more source
Advanced Science, EarlyView.5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi +17 more
wiley +1 more source
Modulation of microRNA activity by semi-microRNAs (smiRNAs)
Frontiers in Genetics, 2012 The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of 19 to 24-nucleotide (nt) long microRNAs. Subsequently incorporated into Ago2 effector complexes, microRNAs are known to regulate messenger RNA (mRNA ...
Isabelle ePlante +6 more
doaj +1 more source
Mammalian Dicer finds a partner [PDF]
EMBO reports, 2005 RNA interference (RNAi) is a complex process that uses small RNAs of 21–23 nucleotides to guide sequence‐specific silencing of genetic information at both the transcriptional and post‐transcriptional levels. There are two main post‐transcriptional gene‐silencing pathways in metazoans: the microRNA (miRNA)‐mediated inhibition of translation and the ...
openaire +2 more sources
Advanced Science, EarlyView.HiST, a multiscale deep learning framework, reconstructs spatially resolved gene expression profiles directly from histological images. It accurately identifies tumor regions, captures intratumoral heterogeneity, and predicts patient prognosis and immunotherapy response.
Wei Li +8 more
wiley +1 more source
Single-molecule analysis of processive double-stranded RNA cleavage by Drosophila Dicer-2 [PDF]
, 2021 Masahiro Naganuma +2 more
openalex +1 more source
Advanced Science, EarlyView.Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen +12 more
wiley +1 more source