Results 101 to 110 of about 41,308 (256)
Deletion of Dicer in the epidermis induces DNA damage.
, 2014 A) Representative hematoxylin and eosin staining of skin sections of 7-8 month old K5-Cre+ control mice, and of 7-8 month old Dicer-ablated mice with (DicerΔ/Δ) or without functional p53 (DicerΔ/Δ, p53Δ/Δ).
Zdenka Matijasevic (590631) +5 more
core +1 more source
Advanced Science, EarlyView.A novel targeted and pH‐responsive MRI contrast agent was integrated with a 3D nnU‐Net deep learning framework to enable accurate delineation of tumor boundary morphology in HER2‐positive breast cancer imaging. ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor ...
Jiaying Zheng +7 more
wiley +1 more source
MicroRNAs in the pathophysiology and treatment of status epilepticus
Frontiers in Molecular Neuroscience, 2013 MicroRNAs are an important class of non-coding RNA which function as post-transcriptional regulators of gene expression in cells, repressing and fine-tuning protein output.
David eHenshall
doaj +1 more source
Dicer and p53 cooperate to suppress skin carcinogenesis.
, 2014 A) Kaplan-Meier tumor curves for various mouse cohorts. K5-Cre+ mice that bear Dicer and p53 wildtype alleles (n = 18) do not present with spontaneous tumors (black curve).
Zdenka Matijasevic (590631) +5 more
core +1 more source
Advanced Science, EarlyView.Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok +13 more
wiley +1 more source
Endocrine Regulations, 2018 Objectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the
Soufi Farhad Ghadiri +5 more
doaj +1 more source
Dicer-null MEFs lacking miRNAs fail to reprogram.
, 2012 (A, B) Timelines of attempt at reprogramming Dicer-null MEFs. The main difference between the two strategies is that (A) transduces reprogramming transcription factors (TFs) 6 days post induction with Cre, while (B) transduces TFs 1 day post induction ...
Chryssa Kanellopoulou (156457) +6 more
core +1 more source
Multifunctional Quantum Sensing Using Single Spins in a van der Waals Crystal
Advanced Science, EarlyView.The work demonstrates a dual quantum sensing of temperature and magnetic field using spin‐complex quantum emitters in hexagonal boron nitride (hBN). Temperature sensing via zero‐phonon‐line shifts and magnetometry via optically detected magnetic resonances, enable simultaneous local thermometry and magnetic‐field measurements.
James Liddle‐Wesolowski +7 more
wiley +1 more source
The Role of Dicer in DNA Damage Repair
, 2012 Dicer is the key component of the RNA interference pathway. Our group and others have reported that knockdown or knockout of Dicer leads to DNA damage in mammalian cells. Two groups recently showed that efficiency of DNA damage repair was greatly reduced
Hong Ren, Kai-Fu Tang
core +1 more source
Chelation‐Driven Dual‐Interface Regulation for Long‐Life Aqueous Zn–I2 Batteries
Advanced Science, EarlyView.Zn2+–TPEN coordination generates TPEN‐derived coordination species (TCC) that contribute to the regulation of both electrode interfaces. At the Zn anode, it creates an interfacial environment with reduced water accessibility that suppresses HER and corrosion while promoting uniform deposition; at the I2 cathode, it captures polyiodide to inhibit ...
Dong Wook Kim +10 more
wiley +1 more source