MicroRNAs are involved in the hypothalamic leptin sensitivity
Epigenetics, 2018 The central nervous system monitors modifications in metabolic parameters or hormone levels (leptin) and elicits adaptive responses such as food intake and glucose homeostasis regulation. Particularly, within the hypothalamus, pro-opiomelanocortin (POMC)
Adel Derghal +6 more
doaj +1 more source
Most \u3cem\u3eCaenorhabditis elegans\u3c/em\u3e MicroRNAs are Individually Not Essential for Development or Viability [PDF]
, 2007 MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding
Abbott, Allison L. +8 more
core +1 more source
Advanced Science, EarlyView.Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai +8 more
wiley +1 more source
Long-lived [1.1.1.1]- and [2.2.1.1]-‘Isopagodane’ dications: novel 4C/2e σ-bishomoaromatic dications† [PDF]
, 1999 G. K. Surya Prakash +8 more
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Dikationether, 3 [1]. Substitutionen an Bis(acridinium)ethern und 9-Trifloxyacridinium-Salzen mit Halogeniden, Pseudohalogeniden und Schwefel-Nucleophilen / Dication Ethers, 3 [1]. Substitution Reactions on Bis(acridinium) Ethers and 9-Trifloxyacridinium Salts by Halides, Pseudohalides and Sulfur Nucleophiles [PDF]
, 1984 B. SINGER, Gerhard Maas
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NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA
Advanced Science, EarlyView.MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen +13 more
wiley +1 more source
Generation of elusive neutrals and dications by neutralization resp. Charge stripping of monocations in beam experiments [PDF]
, 1989 Helmut Schwarz
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ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors
Advanced Science, EarlyView.This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang +14 more
wiley +1 more source
Kinetics and Mechanisms of the Reactions of Organic Cation Radicals and Dications. VII. Competing Second Order Reactions during the Anisylation of the 9-Anisylanthracene Cation Radical. [PDF]
, 1980 Ulla Svanholm +6 more
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High Conversion Efficiency in Intrinsic High Power‐Density Mg2Sn‐GeTe Thermoelectric Generator
Advanced Science, EarlyView.First Mg2Sn–GeTe thermoelectric generator achieves 9% efficiency by strategically modulating power factor–thermal conductivity interplay in intrinsically high‐power‐density system. Abstract Thermoelectric generators (TEGs) offer a sustainable solution for thermal energy harvesting, where maximizing energy output necessitates achieving both high power ...
Xinzhi Wu +6 more
wiley +1 more source