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Diclazuril Inhibits Biofilm Formation and Hemolysis of Staphylococcus aureus
ACS Infectious Diseases, 2021Biofilm formation and hemolysis induced by Staphylococcus aureus are closely related to pathogenicity. However, no drugs exist to inhibit biofilm formation or hemolysis induced by S. aureus in clinical practice. This study found diclazuril had antibacterial action against S.
Jinxin Zheng +10 more
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The Journal of Parasitology, 1995
Diclazuril is an anticoccidial that inhibits tachyzoite production of the RH strain of Toxoplasma gondii by > 97% at a concentration of 0.005 micrograms/ml. The effects of 1.0 microgram/ml diclazuril on the development of 3 strains (RH and 2 tissue cyst formers, GT-1, and WTD-3) of T. gondii in vitro was examined using transmission electron microscopy.
D S, Lindsay +3 more
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Diclazuril is an anticoccidial that inhibits tachyzoite production of the RH strain of Toxoplasma gondii by > 97% at a concentration of 0.005 micrograms/ml. The effects of 1.0 microgram/ml diclazuril on the development of 3 strains (RH and 2 tissue cyst formers, GT-1, and WTD-3) of T. gondii in vitro was examined using transmission electron microscopy.
D S, Lindsay +3 more
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The Journal of Parasitology, 1995
Diclazuril is a benzeneacetonitrile anticoccidial that is also effective in the prevention of toxoplasmosis. The present study was conducted to examine the efficacy of diclazuril alone or in combination with pyrimethamine for the treatment of acute toxoplasmosis in mice.
D S, Lindsay, N S, Rippey, B L, Blagburn
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Diclazuril is a benzeneacetonitrile anticoccidial that is also effective in the prevention of toxoplasmosis. The present study was conducted to examine the efficacy of diclazuril alone or in combination with pyrimethamine for the treatment of acute toxoplasmosis in mice.
D S, Lindsay, N S, Rippey, B L, Blagburn
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Efficacy of Diclazuril against Eimeria dispersa in Turkeys
Avian Diseases, 1991Diclazuril, a new anticoccidial drug, was tested for its efficacy against Eimeria dispersa in turkeys. A dose-titration study indicated that diclazuril at dosages of 0.5, 1, and 2 ppm in the feed was highly effective in terms of weight gain and suppression of lesions, abnormal droppings, and oocyst shedding.
O, Vanparijs, L, Hermans, R, Marsboom
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Efficacy of diclazuril in the control of intestinal coccidiosis in rabbits
Veterinary Parasitology, 1989The anticoccidial efficacy of diclazuril was studied in rabbits artificially infected with Eimeria flavescens, Eimeria intestinalis, Eimeria magna and Eimeria perforans. Continuous administration at 1 and 2 ppm in pelleted feed proved to be highly efficacious in controlling oocyst output and faecal scores.
O, Vanparijs, L, Desplenter, R, Marsboom
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Determination of diclazuril in animal feed by liquid chromatography
Journal of Chromatography A, 1992A method is described for the determination of diclazuril (Janssen Research Compound R64433; trademark Clinacox) in chicken feed at the mg kg(-1) level. Compound R062646, a structure analogous to diclazuril, was used as the interna standard. The drug was extracted from food with acidified methanol.
J, De Kock, M, De Smet, R, Sneyers
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Measurement of the Solubility of Diclazuril and Discussion of the Effect of the Cosolvent
Journal of Chemical & Engineering Data, 2019In this research, the solid–liquid equilibrium solubility of diclazuril was measured by the isothermal saturation method, and the influence of the solvent effect on solubility was discussed. In monosolvents, at the determined temperature, the solubility values of diclazuril decrease according to the order: dimethylformamide (DMF) > acetone ...
Shasha Li, Fan Yin, Dechao Rui
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HPLC semi‐preparative separation of diclazuril enantiomers and racemization in solution
Journal of Separation Science, 2020AbstractDiclazuril has been widely used in poultry feed for prevention and treatment of coccidiosis, and its chiral separation is rarely reported. Herein, semi‐preparative separation method of diclazuril enantiomers has been developed through normal‐phase high‐performance liquid chromatography.
Zhan Huang +6 more
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Efficacy of diclazuril in the prevention and cure of intestinal and hepatic coccidiosis in rabbits
Veterinary Parasitology, 1989The efficacy of diclazuril against intestinal and hepatic coccidiosis was studied in artificially infected rabbits. Prophylaxis against intestinal coccidiosis was evaluated using a mixed infection of Eimeria intestinalis, Eimeria magna and Eimeria perforans. Continuous medication in the feed at 1 p.p.m.
O, Vanparijs +3 more
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Efficacy of Diclazuril against Turkey Coccidiosis in a Floor-Pen Experiment
Avian Diseases, 1989Diclazuril, a new anticoccidial drug, was tested for its efficacy in turkeys against mixed Eimeria infections. A floor-pen trial indicated that diclazuril at dosages of 0.5 ppm and 1 ppm in the feed was highly effective against the major pathogenic species E. adenoeides, E. gallopavonis, and E.
O, Vanparijs, L, Hermans, R, Marsboom
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