Results 151 to 160 of about 89,653 (252)

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1181-1192, May 2026.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley   +1 more source

Intravitreal Cidofovir Injection for Refractory End‐Stage Glaucoma and Vision Loss in Silicone Oil‐Filled Eyes Following Retinal Reattachment Surgery in Dogs: Four Cases

Veterinary Ophthalmology, Volume 29, Issue 3, May 2026.
ABSTRACT Objective To describe the clinical outcome of intravitreal cidofovir injection for palliative management of refractory end‐stage glaucoma and vision loss in silicone oil‐filled eyes following retinal reattachment surgery in dogs. Procedures Medical records of dogs that underwent a single intravitreal cidofovir injection for pharmacologic ...
Sunhyo Kim, Jaeho Shim
wiley   +1 more source

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

Development of Styryl‐Modified 3,4‐Dihydropyrimidin‐2(1H)‐ones as Potential Antitumor Agents

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Styryl‐modified 3,4‐dihydropyrimidin‐2(1H)‐ones (DHPMs), designed from the Eg5 inhibitor monastrol, show markedly enhanced antiproliferative activity in HeLa and MCF‐7 cancer cells. Lead compounds 16 and 17 trigger apoptosis through cell‐line‐specific pathways and downregulate c‐Myc, emerging as promising anticancer candidates.
Konstantinos Panagoulias, Woonghee Kim, Murat Ozdemir, Busra Turan, Adil Mardinoglu, Hasan Turkez, Daniela Trisciuzzi, Orazio Nicolotti, Antonio Di Stefano, Stamatia Vassiliou, Ivana Cacciatore   +10 more
wiley   +1 more source

Central and peripheral analgesia in irradiated rats: reserpine-induced pain model. [PDF]

Sci Rep
Saif-Elnasr M.
europepmc   +1 more source

Comparative greenness assessment for the simultaneous estimation of diclofenac and methocarbamol in their tablets applying synchronous fluorimetry. [PDF]

Sci Rep
Attia M, Hadad GM, Salam RAA, Wahba MEK.
europepmc   +1 more source

Investigation of the drug release modifying property of Pentadesma butyracea gum in diclofenac sodium matrix tablets. [PDF]

PLoS One
Archer MA, Ofori-Kwakye K, Johnson R, Attah IY, Owusu FWA, Jnr Acquah PG, Kipo SL.   +6 more
europepmc   +1 more source

PEGylated Heterofunctional Dendrimers Enable Multivalent Diclofenac Delivery for ROS-Driven Anticancer Activity. [PDF]

ACS Appl Mater Interfaces
Singh A, Sanz Del Olmo N, Malkoch M.
europepmc   +1 more source

Efficacy of tenoxicam for postoperative dental pain: a systematic review of randomized controlled trials. [PDF]

J Dent Anesth Pain Med
Altuhafy M, Kamdar D, Khan J.
europepmc   +1 more source

A Randomized Trial Evaluating the Synergistic Effect of Parenteral Diclofenac and Paracetamol for Pain Management in Adult Males With Acute Limb Injury. [PDF]

Pain Res Manag
Qureshi I, S Qureshi R, Harris T, A Pathan S, Malik AME, Babiker ME, Jamali MA, Bhutta ZA, Thomas SH.   +8 more
europepmc   +1 more source