Results 101 to 110 of about 165,090 (316)
Law Must Be Seen in the Context of the Society in Which it Operates: Dictum 2012
Victoria University Law and Justice Journal, 2012 DICTUM – the Victoria Law School Journal explores topical and contentious legal issues. In 2012 the second volume has been produced and the Editorial Board are to be congratulated in their selection of items representing important contemporary issues ...
Chris Brien
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
, 1995 In a recent issue of Word Ways, Harry Stern closed an otherwise wonderful article by impugning the value of computers in finding anagrams. Since I have no talent for finding them by hand, and rely almost entirely on a program, I felt I should rise on ...
Morton, Mike
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
CONSTRUCŢII ACTANŢIALE CU VERBE MODALE. ANALIZĂ STRUCTURAL-SEMANTICĂ
Studia Universitatis Moldaviae: Stiinte Umanistice, 2010 Modal verbs are potentially polysemantic. Being among the verbs which make up the constructions with predicate actants, they can combine characteristics both of the dictum verbs and the verbs of propositional attitude.
USM ADMIN
doaj
Trans/Form/Ação, 1999 A partir de un poema póstumo de Paul Celan, el presente artículo analiza el dictum de Theodor W. Adorno sobre la imposibilidad de la lírica después de Auschwitz y busca determinar el impacto de tal proposición en la obra de Celan. Al mismo tiempo, indaga
Ricardo Ibarlucía
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Nothing in cancer makes sense except…
BMC Biology, 2018 Paraphrasing Dobzhansky’s famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance.
Mel Greaves
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
What Have We Learned About The Employment Effects of Severance Pay? Further Iterations of Lazear et al. [PDF]
In this study we examine the contribution of severance pay to employment and unemployment development using data on industrialized OECD countries. Our starting point is Lazear’s (1990) dictum that severance payment requirements adversely impact the labor
John T. Addison, Paulino Teixeira
core