Results 151 to 160 of about 165,090 (316)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Pseudoachalasia in an Achalasia Patient: A Ticking Time Bomb. [PDF]

ACG Case Rep J
Goodrich HWF, Muniraj T, Masoud AE.
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Syphilis Uveitis: A Case of Occam's Razor, Hickam's Dictum, and Crabtree's Bludgeon. [PDF]

Cureus
Sethi D, Mohiddin O, Kelleher C, Kasetty VM, Kumar N, Desai UR, Hamad A.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Orthoplastic Surgery: A Shining Example for 'Collaborate and Flourish' in Multidisciplinary Care. [PDF]

Indian J Plast Surg
Venkatramani H.
europepmc   +1 more source

Hickam's dictum

, 2019
Daniel Bell, Rohit Sharma
openaire   +1 more source

Hickam's dictum: Myasthenia Gravis presenting concurrently with Graves' disease

BMJ Case Reports, 2017
S. Sehgal, R. Rebello, L. Wolmarans, M. Elston   +3 more
semanticscholar   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Pulmonary co-infection with <i>Pneumocystis jirovecii</i> and <i>Histoplasma capsulatum</i>. Hickam's dictum or Occam's razor. [PDF]

Germs
Severiche-Bueno DF, Galvis-Blanco SJ, Mugnier J.   +2 more
europepmc   +1 more source