Results 41 to 50 of about 18,040 (290)

Unorthodox Thoughts on the Economic Crisis and the Dictum of Protagoras

open access: yesCadmus, 2018
The current economic crisis can be explained but we must remember that the crisis is the product of human behavior, both theoretical and practical, and not the product of some force of nature or mathematical law.
Gerald Gutenschwager
doaj  

Pancytopaenia and breathlessness: Hickam’s Dictum prevails! [PDF]

open access: yesThorax, 2018
Dr Andrew W Creamer (AWC), Respiratory Registrar : A 70-year-old retired teacher was referred to the respiratory clinic with a 12-month history of progressive exertional dyspnoea and dry cough. He denied haemoptysis, constitutional symptoms or diurnal variation.
Creamer, Andrew   +3 more
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural Types of Speech Acts with the Explicit Mode of Belief and their Expressive Properties in Scientific Dialogue

open access: yesДискурс
Introduction. The article is about identifying structural and pragmatic features of references to belief presented in scientific dialogue that involves the verbal interaction of scientists and develops in a spontaneous way at a scientific forum of any ...
O. N. Chalova
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

THE PROBLEM OF GENRE DEFINITION OF THE RUBRIC OF “AGONY COLUMN” IN GLOSSY MAGAZINES

open access: yesВестник Кемеровского государственного университета, 2014
This paper deals with the problem of genre definition of the rubric of “agony column” in glossy magazines Cosmopolitan, Men’s Health. The profile of a speech genre by T. V. Shmelyova was used as the model for the description of the genre.
N. V. Lazeeva, L. P. Prokhorova
doaj  

La (in)traducibilidad de un texto literario: nullum est iam dictum quod non dictum sit prius

open access: yesEstudios de Traducción, 2011
Este artículo investiga un concepto emergente de traducción literaria que trata de integrar los elementos discursivos y culturales. Tras prestar atención a la creatividad singular que el traductor ha de aplicar en su tarea, el trabajo revisa el concepto ...
Juan de Dios Torralbo Caballero
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Actant Models of Kazakh Anthroponyms-Composites with Substantive and Verb Components

open access: yesNames
The Kazakh anthroponymicon during its centuries-old history did not experience serious pressure from religious and state institutions and therefore is characterized by a high degree of non-formalization. It has preserved the ancient traditions of naming,
Zifa Temirgazina   +2 more
doaj   +1 more source

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