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Rho Signaling in Dictyostelium discoideum

2016
Small GTPases of the Rho family are ubiquitous molecular switches involved in the regulation of most actin cytoskeleton dependent processes and many other processes not directly linked to actin. D. discoideum is a well-established model organism for studies of the actin cytoskeleton and its regulation by signal transduction pathways. D.
Rivero Crespo, Francisco   +1 more
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Modelling Dictyostelium discoideum Morphogenesis: the Culmination

Bulletin of Mathematical Biology, 2002
The culmination of the morphogenesis of the cellular slime mould Dictyostelium discoideum involves complex cell movements which transform a mound of cells into a globule of spores on a slender stalk. We show that cyclic AMP signalling and differential adhesion, combined with cell differentiation and slime production, are sufficient to produce the ...
Marée, A.F.M., Hogeweg, P.
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The Model Organism Dictyostelium discoideum

2013
Much of our knowledge of molecular cellular functions is based on studies with a few number of model organisms that were established during the last 50 years. The social amoeba Dictyostelium discoideum is one such model, and has been particularly useful for the study of cell motility, chemotaxis, phagocytosis, endocytic vesicle traffic, cell adhesion ...
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The Inositolcycle of Dictyostelium Discoideum

1990
Transmembrane signal transduction is characterized largely by the interaction between its components: ligand, receptor on the surface of cells, G-protein subunits at the inner face of the plasma membrane, and effector enzymes. The effector enzymes may vary widely depending on the organism and the ligand, and include adenylate cyclase, guanylate cyclase,
Peter J. M. Van Haastert   +9 more
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The Genome of Dictyostelium discoideum.

Methods in molecular biology (Clifton, N.J.), 2006
The Dictyostelium discoideum genome has been sequenced, assembled and annotated to a high degree of reliability. The parts-list of proteins and RNA encoded by the six chromosomes can now be accessed and analyzed. One of the initial surprises was the remarkably large number of genes that are shared with plants, animals, and fungi that must have been ...
Adam, Kuspa, William F, Loomis
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