The Dictyostelium Kinome—Analysis of the Protein Kinases from a Simple Model Organism [PDF]
PLoS Genetics, 2006 Dictyostelium discoideum is a widely studied model organism with both unicellular and multicellular forms in its developmental cycle. The Dictyostelium genome encodes 285 predicted protein kinases, similar to the count of the much more advanced ...
Gerard Manning, Petra Fey
exaly +3 more sources
Extracellular adenosine deamination primes tip organizer development in Dictyostelium [PDF]
eLifeAmmonia is a morphogen in Dictyostelium and is known to arise from the catabolism of proteins and RNA. However, we show that extracellular adenosine deamination catalysed by ‘adenosine deaminase-related growth factor’ (ADGF) is a major source of ammonia ...
Pavani Hathi, Baskar Ramamurthy
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Cell biology of Dictyostelium [PDF]
BMC Molecular and Cell BiologyThe Cell Biology of Dictyostelium article collection highlights the benefits of using Dictyostelium as a model system for studying fundamental cellular processes.
Robert J. Huber +2 more
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Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in Dictyostelium [PDF]
CellsDictyostelium is a unique model used to study the complex and interactive cyclic nucleotide signaling pathways that regulate multicellular development.
Pundrik Jaiswal, Alan R. Kimmel
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Stochastic noise and synchronisation during Dictyostelium aggregation make cAMP oscillations robust [PDF]
, 2007 The molecular network, which underlies the oscillations in the concentration of adenosine 3′, 5′-cyclic monophosphate (cAMP) during the aggregation phase of starvation-induced development in Dictyostelium discoideum, achieves remarkable levels of robust ...
Bates, Declan +3 more
core +14 more sources
Opposite functions of RapA and RapC in cell adhesion and migration in Dictyostelium
Animal Cells and Systems, 2021 There are three Rap proteins in Dictyostelium. RapA is a key regulator of cell adhesion and cytoskeletal rearrangement. Recently, RapC has been reported to be involved in cytokinesis, cell migration, and multicellular development.
Jihyeon Jeon +2 more
doaj +1 more source
Dictyostelium AMPKα regulates aggregate size and cell-type patterning [PDF]
Open Biology, 2017 Starved Dictyostelium cells aggregate into groups of nearly 105 cells. AMPK is a highly conserved serine/threonine protein kinase consisting of a catalytic and two regulatory subunits.
Ranjana Maurya +2 more
doaj +1 more source
The Cell Density Factor CMF Regulates the Chemoattractant Receptor cAR1 in Dictyostelium [PDF]
, 1996 Starving Dictyostelium cells aggregate by chemotaxis to cAMP when a secreted protein called conditioned medium factor (CMF) reaches a threshold concentration.
Bishop, John D., +2 more
core +13 more sources
The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions [PDF]
Open Biology, 2015 Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes.
Qiuhong Xiong +4 more
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Dictyostelium spastin is involved in nuclear envelope dynamics during semi-closed mitosis
Nucleus, 2022 Dictyostelium amoebae perform a semi-closed mitosis, in which the nuclear envelope is fenestrated at the insertion sites of the mitotic centrosomes and around the central spindle during karyokinesis.
Ulrike Schweigel +4 more
doaj +1 more source