Results 31 to 40 of about 17,348 (180)

Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, 2021
The social amoeba Dictyostelium discoideum is a model organism that is used to investigate many cellular processes including chemotaxis, cell motility, cell differentiation, and human disease pathogenesis.
Holly N. Haver, K. Matthew Scaglione, K. Matthew Scaglione, K. Matthew Scaglione   +3 more
doaj   +1 more source

Investigation of a potential role for aldose reductase AlrA in tetrahydropteridine synthesis in Dictyostelium discoideum Ax2

Pteridines, 2017
Dictyostelium discoideum Ax2 is well-known for the synthesis of d-threo-tetrahydrobiopterin (DH4) with a smaller amount of l-erythro-tetrahydrobiopterin (BH4).
Kim Hye-Lim, Ryu Hyun-Chul, Park Young Shik   +2 more
doaj   +1 more source

Extracellular signaling in Dictyostelium

The International Journal of Developmental Biology, 2019
In the last few decades, we have learned a considerable amount about how eukaryotic cells communicate with each other, and what it is the cells are telling each other. The simplicity of Dictyostelium discoideum, and the wide variety of available tools to study this organism, makes it the equivalent of a hydrogen atom for cell and developmental biology.
Kristen M, Consalvo, Ramesh, Rijal, Yu, Tang, Sara A, Kirolos, Morgan R, Smith, Richard H, Gomer   +5 more
openaire   +3 more sources

Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum [PDF]

Genome Biology, 2011
Abstract Background The social amoebae (Dictyostelia) are a diverse group of Amoebozoa that achieve multicellularity by aggregation and undergo morphogenesis into fruiting bodies with terminally differentiated spores and stalk cells.
Sucgang, Richard, Kuo, Alan, Tian, Xiangjun, Salerno, William, Parikh, Anup, Feasley, Christa L, Dalin, Eileen, Tu, Hank, Huang, Eryong, Barry, Kerrie, Lindquist, Erika, Shapiro, Harris, Bruce, David, Schmutz, Jeremy, Salamov, Asaf, Fey, Petra, Gaudet, Pascale, Anjard, Christophe, Madan Babu, M, Basu, Siddhartha, Bushmanova, Yulia, van der Wel, Hanke, Katoh-Kurasawa, Mariko, Dinh, Christopher, Coutinho, Pedro M, Saito, Tamao, Elias, Marek, Schaap, Pauline, Kay, Robert R, Henrissat, Bernard, Eichinger, Ludwig, Rivero, Francisco, Putnam, Nicholas H, West, Christopher M, Loomis, William F, Chisholm, Rex L, Shaulsky, Gad, Strassmann, Joan E, Queller, David C, Kuspa, Adam, Grigoriev, Igor V   +40 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Triparental inheritance in Dictyostelium [PDF]

Proceedings of the National Academy of Sciences, 2018
Sex promotes the recombination and reassortment of genetic material and is prevalent across eukaryotes, although our knowledge of the molecular details of sexual inheritance is scant in several major lineages. In social amoebae, sex involves a promiscuous mixing of cytoplasm before zygotes consume the majority of cells, but for ...
Gareth Bloomfield, Peggy Paschke, Marina Okamoto, Tim J. Stevens, Hideko Urushihara   +4 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Information Transmission Strategies for Self‐Organized Robotic Aggregation

Advanced Robotics Research, EarlyView.
In this review, we discuss how information transmission influences the neighbor‐based self‐organized aggregation of swarm robots. We focus specifically on local interactions regarding information transfer and categorize previous studies based on the functions of the information exchanged.
Shu Leng, Zihan Li, Yifeng Shao, Jinhao Liu, Li Yu, Shuguang Li   +5 more
wiley   +1 more source

Analysis of Chemotaxis in Dictyostelium [PDF]

, 2011
Dictyostelium discoideum is an excellent model organism for the study of directed cell migration, since Dictyostelium cells show robust chemotactic responses to the chemoattractant cAMP. Many powerful experimental tools are applicable, including forward and reverse genetics, biochemistry, microscopy, and proteomics.
Huaqing, Cai, Chuan-Hsiang, Huang, Peter N, Devreotes, Miho, Iijima   +3 more
openaire   +2 more sources