The Dictyostelium Kinome—Analysis of the Protein Kinases from a Simple Model Organism [PDF]
PLoS Genetics, 2006 Dictyostelium discoideum is a widely studied model organism with both unicellular and multicellular forms in its developmental cycle. The Dictyostelium genome encodes 285 predicted protein kinases, similar to the count of the much more advanced ...
Petra Fey +2 more
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Beyond cargo clearance: p62 coordinates cAMP signalling and autophagy to drive cell fate decisions in Dictyostelium discoideum [PDF]
Autophagy Reportsp62 is a multi-domain selective autophagy receptor and signaling scaffold conserved across eukaryotes. However, its evolutionary roots and functional significance in early-diverging eukaryotes like Dictyostelium have remained unexplored.
Saksham Gautam, Shweta Saran
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Extracellular adenosine deamination primes tip organizer development in Dictyostelium [PDF]
eLifeAmmonia is a morphogen in Dictyostelium and is known to arise from the catabolism of proteins and RNA. However, we show that extracellular adenosine deamination catalysed by ‘adenosine deaminase-related growth factor’ (ADGF) is a major source of ammonia ...
Pavani Hathi, Baskar Ramamurthy
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Cell biology of Dictyostelium [PDF]
BMC Molecular and Cell BiologyThe Cell Biology of Dictyostelium article collection highlights the benefits of using Dictyostelium as a model system for studying fundamental cellular processes.
Robert J. Huber +2 more
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Opposite functions of RapA and RapC in cell adhesion and migration in Dictyostelium
Animal Cells and Systems, 2021 There are three Rap proteins in Dictyostelium. RapA is a key regulator of cell adhesion and cytoskeletal rearrangement. Recently, RapC has been reported to be involved in cytokinesis, cell migration, and multicellular development.
Jihyeon Jeon +2 more
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Antibody Reports, 2022 The AK423 antibody, raised against Dictyostelium actin, recognizes both Dictyostelium and human actin by western blot. However, it recognizes Dictyostelium actin with higher affinity than human actin.
Anna Marchetti
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Dictyostelium AMPKα regulates aggregate size and cell-type patterning [PDF]
Open Biology, 2017 Starved Dictyostelium cells aggregate into groups of nearly 105 cells. AMPK is a highly conserved serine/threonine protein kinase consisting of a catalytic and two regulatory subunits.
Ranjana Maurya +2 more
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The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions [PDF]
Open Biology, 2015 Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes.
Qiuhong Xiong +4 more
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Dictyostelium spastin is involved in nuclear envelope dynamics during semi-closed mitosis
Nucleus, 2022 Dictyostelium amoebae perform a semi-closed mitosis, in which the nuclear envelope is fenestrated at the insertion sites of the mitotic centrosomes and around the central spindle during karyokinesis.
Ulrike Schweigel +4 more
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Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase [PDF]
Open Biology, 2015 The network of protein–protein interactions of the Dictyostelium discoideum autophagy pathway was investigated by yeast two-hybrid screening of the conserved autophagic proteins Atg1 and Atg8.
Ana Mesquita +5 more
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