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Auxotrophic mutants of Dictyostelium discoideum
Nature, 1978THE cellular slime mould Dictyostelium discoideum is a unicellular organism in its vegetative stage. On starvation, slime mould amoebae gather into aggregates which pass through a morphogenesis culminating in mature fruiting bodies consisting of dead stalk cells supporting a sphere of viable spores1. The laboratory strains of D. discoideum are normally
J, Franke, R, Kessin
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Modelling Dictyostelium discoideum Morphogenesis: the Culmination
Bulletin of Mathematical Biology, 2002The culmination of the morphogenesis of the cellular slime mould Dictyostelium discoideum involves complex cell movements which transform a mound of cells into a globule of spores on a slender stalk. We show that cyclic AMP signalling and differential adhesion, combined with cell differentiation and slime production, are sufficient to produce the ...
Marée, A.F.M., Hogeweg, P.
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Pacemaker mutants of Dictyostelium discoideum
Developmental Biology, 1974Abstract In this paper, I report measurements of the time intervals between aggregation waves in two morphogenetic mutants of Dictyostelium discoideum NC-4. The mutants both have abnormal wave periodicity and their abnormalities are interpreted in terms of defects in the cellular properties which underlie wave propagation.
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Rho Signaling in Dictyostelium discoideum
2016Small GTPases of the Rho family are ubiquitous molecular switches involved in the regulation of most actin cytoskeleton dependent processes and many other processes not directly linked to actin. D. discoideum is a well-established model organism for studies of the actin cytoskeleton and its regulation by signal transduction pathways. D.
Rivero Crespo, Francisco +1 more
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Extracellular folate deaminase of Dictyostelium discoideum
Biochimica et Biophysica Acta (BBA) - General Subjects, 1981Folate deaminase released from cells of Dictyostelium discoideum is heterogeneous with respect to molecular weight and stability at 60 degrees C. The most heat-stable component isoelectrofocuses in a broad band at approx. pH 6. The Km value of this component for folate is approx. 7 x 10(-7)M and Mr approx. 40 000.
R L, Bernstein +3 more
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Dictyostelium discoideum cAMP Chemotaxis Pathway
Science's STKE, 2003Cells migrating directionally toward a chemoattractant display highly polarized cytoskeletal organizations, with F-actin predominantly at the anterior and myosin II localized laterally and posteriorly. Dictyostelium discoideum has proven a remarkable model system for elucidating signaling pathways that regulate this
A. R. Kimmel, C. A. Parent
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CHEMOATTRACTANT SIGNALING IN DICTYOSTELIUM DISCOIDEUM
Annual Review of Cell and Developmental Biology, 2004▪ Abstract Dictyostelium is an accessible organism for studies of signaling via chemoattractant receptors. Chemoattractant-mediated signaling events and components are reviewed and presented as a series of connected modules, including excitation, inhibition, G protein–independent responses, early gene expression, inositol lipids, PH domain-containing
Carol L, Manahan +3 more
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Modelling Dictyostelium discoideum Morphogenesis
2001Morphogenesis of the social amoebae Dictyostelium discoideum results from the aggregation of individual cells to form a multicellular hemispherical cell mass, the mound. In the mound the cells differentiate into several cell types. These cell types arise initially in random location in the mound, but then sort out from one another to form a slug.
Bakhtier Vasiev, Cornelis J. Weijer
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