Results 51 to 60 of about 3,880 (155)

A SINE-derived element constitutes a unique modular enhancer for mammalian diencephalic Fgf8. [PDF]

PLoS ONE, 2012
Transposable elements, including short interspersed repetitive elements (SINEs), comprise nearly half the mammalian genome. Moreover, they are a major source of conserved non-coding elements (CNEs), which play important functional roles in regulating ...
Akiko Nakanishi, Naoki Kobayashi, Asuka Suzuki-Hirano, Hidenori Nishihara, Takeshi Sasaki, Mika Hirakawa, Kenta Sumiyama, Tomomi Shimogori, Norihiro Okada   +8 more
doaj   +1 more source

Clinical neuroanatomy teaching at Peking University Health Science Center: Evolution, current practice, and future direction

Anatomical Sciences Education, EarlyView.
Abstract Neuroanatomy has been considered one of the most challenging subjects in medical education, often leading to “neurophobia” and discouraging students from pursuing neurological specialties. At PKUHSC, the curriculum has evolved from a traditional, discipline‐based model to a technology‐enhanced, integrated “Nervous System” module for ...
Xuan Fang, Man Li, Xiaodan Hu, Chang Su, Shan Ye, Xianzhong Shi, Xiaomei Yang, Changman Zhou, Weiguang Zhang, Chunhua Chen   +9 more
wiley   +1 more source

Melanocortin receptor 3 and 4 mRNA expression in the adult female Syrian hamster brain

Frontiers in Molecular Neuroscience, 2023
Melanocortin 3 receptors (MC3R) and melanocortin 4 receptors (MC4R) are vital in regulating a variety of functions across many species. For example, the dysregulation of these receptors results in obesity and dysfunction in sexual behaviors.
Megan A. L. Hall, Abigail L. Kohut-Jackson, Anna C. Peyla, Gloria D. Friedman, Nicole J. Simco, Johnathan M. Borland, Robert L. Meisel   +6 more
doaj   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Influence of an Aromatic Amino Acid Decarboxylase Inhibitor on GTP Cyclohydrolase I Activity in the Rat Brain

Pteridines, 1997
Based on the hypothesis that catecholamine decreases may cause increases in biopterin, we measured the GTP cyclohydrolase I(GTPCH-I) activity and biopterin content in the cerebral cortex, midbrain/diencephalon, cerebeilum, pons/medulla oblongata ...
Sakamoto Hideo, Fujita Ko, Kuzuya Hiroshi   +2 more
doaj   +1 more source

Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks

The Journal of Poultry Science, 2013
In the present study, we determined the effects of oral administration of L- and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L- and D-Asp in the brain and ...
Edi Erwan, Shozo Tomonaga, Taketo Ohmori, Yuta Mutaguchi, Toshihisa Ohshima, Mao Nagasawa, Shinobu Yasuo, Yoshinaga Tamura, Mitsuhiro Furuse   +8 more
doaj   +1 more source

Environmentally-relevant concentrations of the antipsychotic drugs sulpiride and clozapine induce abnormal dopamine and serotonin signaling in zebrafish brain

Scientific Reports, 2022
The presence of drugs in surface and groundwaters adversely affects the physiological function of non-target organisms due special activities that can pose a serious threats to various forms of aquatic life.
Bo Zhang, Xijian Peng, Xiumei Sun, Yuanming Guo, Tiejun Li   +4 more
doaj   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan, Andrew J. Tague, Ashna A. Kumar, Marie Ranson, Christopher J. T. Hyland, Shane R. Ellis   +5 more
wiley   +2 more sources

Multi-neuromeric origin of tyrosine hydroxylase-positive neurons within the substantia nigra and ventral tegmental area

Frontiers in Neuroanatomy
During early developmental stages, the brain is divided into three primary regions: the forebrain (prosencephalon), the hindbrain (rhombencephalon), and the spinal cord.
José L. Ferran, José L. Ferran, Franco Lucero-Arteaga, Franco Lucero-Arteaga, Abdelmalik Ayad, Abdelmalik Ayad, Yevheniy Kutsenko, Yevheniy Kutsenko, A. Alonso, A. Alonso, B. Ribeiro Do-Couto, B. Ribeiro Do-Couto, M. Á. García-Cabezas, Kuei Y. Tseng   +13 more
doaj   +1 more source