Results 1 to 10 of about 74,513 (285)

Loss of CA12 drive proliferation and fibrosis in type i congenital pulmonary airway malformation via promoting abnormal activation of SHH signaling [PDF]

Cell Communication and Signaling
Congenital pulmonary airway malformation (CPAM), especially type I, is an uncommon developmental lung defect marked by abnormal proliferation of pseudostratified ciliated columnar epithelium (PCCE) and the presence of cystic lesions.
Zefeng Lin, Xinwen Zhang, Jianhua Liang, Jiachi Liao, Fan Sai Hou Alexandre, Yunyu He, Hongmei Wu, Qinglin Yang, Dongmei Huang, Yixi Ling, Le Li, Jiahang Zeng   +11 more
doaj   +2 more sources

Intracellular Ca2+ is not essential for SHH signaling but is promoted by Shh ligand in embryonic fibroblasts

BMC Molecular and Cell Biology
Background Sonic Hedgehog (SHH) signaling pathway controls cell proliferation, differentiation, and organ formation. The changes in Ca2+ and their regulatory role in the context of activated SHH signaling have not been fully examined.
Xuanming Shi, Zhaomin Wang, Shupeng Li, Yiming Pan, Bing Shen, Shuzhen Liu   +5 more
doaj   +3 more sources

CMA‐mediated USP9X degradation promotes SHH medulloblastoma progression by facilitating SUFU ubiquitination [PDF]

Clinical and Translational Medicine
Background Medulloblastoma (MB) represents the most prevalent malignant paediatric brain tumour, characterised by the sonic Hedgehog molecular subtype (SHH‐MB), which is driven by aberrant activation of the SHH signalling cascade.
Binbin Gao, Qin Zhu, Lun Kuang, Jiahui Li, Qingyue Meng, Bo'ang Han, Yu Wang, Xinyi Zhang, Xiangxiang Zhang, Xinfa Wang, Tingting Yu, Shen Yue, Chen Liu   +12 more
doaj   +2 more sources

SHh activity and localization is regulated by perlecan [PDF]

Biological Research, 2011
Proliferation and cell fate determination in the developing embryo are extrinsically regulated by multiple interactions among diverse secreted factors, such as Sonic Hedgehog (SHh), which act in a concentration-dependent manner.
Verónica Palma, Héctor Carrasco, Gisela Reinchisi, Gonzalo Olivares, Fernando Faunes, Juan Larraín   +5 more
doaj   +14 more sources

The transcriptional landscape of Shh medulloblastoma [PDF]

Nature Communications, 2021
AbstractSonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated ...
Skowron, Patryk, Farooq, Hamza, Cavalli, Florence, Morrissy, A, Ly, Michelle, Hendrikse, Liam, Wang, Evan, Djambazian, Haig, Zhu, Helen, Mungall, Karen, Trinh, Quang, Zheng, Tina, Dai, Shizhong, Stucklin, Ana, Vladoiu, Maria, Fong, Vernon, Holgado, Borja, Nor, Carolina, Wu, Xiaochong, Abd-Rabbo, Diala, Bérubé, Pierre, Wang, Yu, Luu, Betty, Suarez, Raul, Rastan, Avesta, Gillmor, Aaron, Lee, John, Zhang, Xiao, Daniels, Craig, Dirks, Peter, Malkin, David, Bouffet, Eric, Tabori, Uri, Loukides, James, Doz, François, Bourdeaut, Franck, Delattre, Olivier, Masliah-Planchon, Julien, Ayrault, Olivier, Kim, Seung-Ki, Meyronet, David, Grajkowska, Wieslawa, Carlotti, Carlos, de Torres, Carmen, Mora, Jaume, Eberhart, Charles, van Meir, Erwin, Kumabe, Toshihiro, French, Pim, Kros, Johan, Jabado, Nada, Lach, Boleslaw, Pollack, Ian, Hamilton, Ronald, Rao, Amulya, Giannini, Caterina, Olson, James, Bognár, László, Klekner, Almos, Zitterbart, Karel, Phillips, Joanna, Thompson, Reid, Cooper, Michael, Rubin, Joshua, Liau, Linda, Garami, Miklós, Hauser, Peter, Li, Kay, Ng, Ho-Keung, Poon, Wai, Yancey Gillespie, G, Chan, Jennifer, Jung, Shin, Mclendon, Roger, Thompson, Eric, Zagzag, David, Vibhakar, Rajeev, Ra, Young, Garre, Maria, Schüller, Ulrich, Shofuda, Tomoko, Faria, Claudia, López-Aguilar, Enrique, Zadeh, Gelareh, Hui, Chi-Chung, Ramaswamy, Vijay, Bailey, Swneke, Jones, Steven, Mungall, Andrew, Moore, Richard, Calarco, John, Stein, Lincoln, Bader, Gary, Reimand, Jüri, Ragoussis, Jiannis, Weiss, William, Marra, Marco, Suzuki, Hiromichi, Taylor, Michael   +98 more
openaire   +11 more sources

Genomic and dietary discontinuities during the Mesolithic and Neolithic in Sicily

iScience, 2022
Summary: Sicily is a key region for understanding the agricultural transition in the Mediterranean because of its central position. Here, we present genomic and stable isotopic data for 19 prehistoric Sicilians covering the Mesolithic to Bronze Age ...
He Yu, Marieke S. van de Loosdrecht, Marcello A. Mannino, Sahra Talamo, Adam B. Rohrlach, Ainash Childebayeva, Vanessa Villalba-Mouco, Franziska Aron, Guido Brandt, Marta Burri, Cäcilia Freund, Rita Radzeviciute, Raphaela Stahl, Antje Wissgott, Helen Fewlass, Antonio Tagliacozzo, Marcello Piperno, Sebastiano Tusa, Carmine Collina, Vittoria Schimmenti, Rosaria Di Salvo, Kay Prüfer, Cosimo Posth, Jean-Jacques Hublin, Detlef Gronenborn, Didier Binder, Choongwon Jeong, Wolfgang Haak, Johannes Krause   +28 more
doaj   +1 more source

Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish [PDF]

Open Biology, 2017
Zebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal.
Ana Ribeiro, Joana F. Monteiro, Ana C. Certal, Ana M. Cristovão, Leonor Saúde   +4 more
doaj   +1 more source

Expression of a hindlimb-determining factor Pitx1 in the forelimb of the lizard Pogona vitticeps during morphogenesis [PDF]

Open Biology, 2016
With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology.
Jane Melville, Sumitha Hunjan, Felicity McLean, Georgia Mantziou, Katja Boysen, Laura J. Parry   +5 more
doaj   +1 more source

miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation

Cells, 2020
During the development of the central nervous system, the proliferation of neural progenitors and differentiation of neurons and glia are tightly regulated by different transcription factors and signaling cascades, such as the Wnt and Shh pathways.
Lavanya Adusumilli, Nicola Facchinello, Cathleen Teh, Giorgia Busolin, Minh TN Le, Henry Yang, Giorgia Beffagna, Stefano Campanaro, Wai Leong Tam, Francesco Argenton, Bing Lim, Vladimir Korzh, Natascia Tiso   +12 more
doaj   +1 more source

Combined HIF-1α and SHH Up-Regulation Is a Potential Biomarker to Predict Poor Prognosis in Postoperative Hepatocellular Carcinoma

Journal of Investigative Surgery, 2022
Background Hypoxia-inducible factor-1α (HIF-1α) or sonic hedgehog (SHH) is associated with hepatocellular carcinoma (HCC) progression. Hypoxia inhibits ferroptosis, which induces cancer cell death. However, the correlation between the combined HIF-1α and
Jiali Zhao, Guifang Zeng, En Lin, Chaonong Cai, Peiping Li, Baojia Zou, Jian Li   +6 more
doaj   +1 more source