Results 11 to 20 of about 74,513 (285)
A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development
PLOS Genetics, 2016 Cleft palate is among the most common birth defects in humans. Previous studies have shown that Shh signaling plays critical roles in palate development and regulates expression of several members of the forkhead-box (Fox) family transcription factors, including Foxf1 and Foxf2, in the facial primordia.
Jingyue Xu +5 more
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Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling [PDF]
Nature Communications, 2014 The distribution of Sonic Hedgehog (Shh) is a highly regulated and critical process for development. Several negative feedback mechanisms are in place, including the Shh-induced upregulation of Hedgehog-interacting protein (Hhip). Hhip sequesters Shh, leading to a non-cell autonomous inhibition of the pathway. Hhip overexpression has a severe effect on
Kwong, Lina +2 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on SHH (Sonic hedgehog), with data on DNA, on the protein encoded, and where the gene is implicated.
Magnaldo, T
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Molecular Oncology, 2022 Sonic hedgehog (Shh)‐driven medulloblastoma (Shh MB) cells are dependent on constitutive Shh signaling, but targeted treatment of Shh MB has been ineffective due to drug resistance.
Liangping Yuan +9 more
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AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation
Cell & Bioscience, 2023 Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients.
Jing Cai +12 more
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Etiopathogenetic Similarities of Combined Forms of Localized Scleroderma and Vitiligo
Вопросы современной педиатрии, 2020 Vitiligo is a common skin disease characterized by idiopathic progressive skin hypomelanosis. Vitiligo is associated with several comorbid autoimmune diseases such as localized scleroderma.
Nikolay N. Murashkin +6 more
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Crosstalk between Shh and TGF-β signaling in cyclosporine-enhanced cell proliferation in human gingival fibroblasts. [PDF]
PLoS ONE, 2013 BACKGROUND: Immunosuppressant cyclosporine-A induces gingival hyperplasia, which is characterized by increased fibroblast proliferation and overproduction of extracellular matrix components and regulated by transforming growth factor-beta (TGF-β).
Yi Chung, Earl Fu
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Coordination of limb bud development : the role of SHH in PD limb bud patterning [PDF]
, 2012 The limb bud serves as an excellent model to investigate the signals involved in diverse processes during embryonic development. Limb bud development is controlled by complex regulatory networks that instruct coordinated patterning and proliferation of ...
Probst, Simone
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LRP1 mediates the Shh-induced endocytosis of the GPC3-Shh complex [PDF]
Journal of Cell Science, 2012 Glypican-3 (GPC3) is a heparan sulfate (HS) proteoglycan that is bound to the cell membrane through a glycosylphosphatidylinositol link. This glypican regulates embryonic growth by inhibiting the hedhehog (Hh) signaling pathway. GPC3 binds Hh and competes with Patched (Ptc), the Hh receptor, for Hh binding.
Mariana I. Capurro +2 more
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Interlinked signaling feedback loops and self-regulation during vertebrate limb development [PDF]
, 2009 Reliable organ and tissue morphogenesis seems to depend on self-regulatory mechanisms that are able to buffer spontaneous and/or genetic variations. While the analysis of the interactions of BMPs with their antagonists during gastrulation has provided ...
Bénazet, Jean-Denis
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