A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development [PDF]
PLOS Genetics, 2016 Cleft palate is among the most common birth defects in humans. Previous studies have shown that Shh signaling plays critical roles in palate development and regulates expression of several members of the forkhead-box (Fox) family transcription factors, including Foxf1 and Foxf2, in the facial primordia.
Jingyue Xu +5 more
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Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling [PDF]
Nature Communications, 2014 The distribution of Sonic Hedgehog (Shh) is a highly regulated and critical process for development. Several negative feedback mechanisms are in place, including the Shh-induced upregulation of Hedgehog-interacting protein (Hhip). Hhip sequesters Shh, leading to a non-cell autonomous inhibition of the pathway. Hhip overexpression has a severe effect on
Kwong, Lina +2 more
openaire +6 more sources
Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]
, 2008 [eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
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The role of Sulf1 during Sonic hedgehog mediated neural patterning [PDF]
, 2011 Heparan sulphate proteoglycans (HSPGs) are large molecules distributed ubiquitously, both at the cell surface and within the extracellular matrix. These molecules are known to play essential roles in developmental cell signalling, and the differential ...
Ramsbottom, Simon.A
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Molecular profiling of pediatric medulloblastoma in Kazakhstan: Genomic alterations, subgroup distribution, and survival. [PDF]
Brain PatholA practical formalin‐fixed, paraffin‐embedded (FFPE)‐based molecular workflow integrating pathology, immunohistochemistry, and genomic profiling provides clinically meaningful subgroup classification of pediatric medulloblastoma and expands molecular evidence from an underrepresented Central Asian population. Abstract Medulloblastoma is the most common
Bolatov A +9 more
europepmc +2 more sources
Etiopathogenetic Similarities of Combined Forms of Localized Scleroderma and Vitiligo
Вопросы современной педиатрии, 2020 Vitiligo is a common skin disease characterized by idiopathic progressive skin hypomelanosis. Vitiligo is associated with several comorbid autoimmune diseases such as localized scleroderma.
Nikolay N. Murashkin +6 more
doaj +1 more source
AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation
Cell & Bioscience, 2023 Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients.
Jing Cai +12 more
doaj +1 more source
Mapping the Shh long-range regulatory domain [PDF]
, 2014 Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms.
Hill, Robert E +3 more
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AOSNP-ADAPTR resource level-based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors. [PDF]
Brain PatholResource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Sarkar C +12 more
europepmc +2 more sources
Coordination of limb bud development : the role of SHH in PD limb bud patterning [PDF]
, 2012 The limb bud serves as an excellent model to investigate the signals involved in diverse processes during embryonic development. Limb bud development is controlled by complex regulatory networks that instruct coordinated patterning and proliferation of ...
Probst, Simone
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