Results 41 to 50 of about 74,513 (285)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding

Molecules, 2019
Sonic hedgehog (Shh) signaling plays a tumor-promoting role in many epithelial cancers. Cancer cells produce soluble a Shh that signals to distant stromal cells that express the receptor Patched (Ptc).
Dominique Manikowski, Petra Jakobs, Hamodah Jboor, Kay Grobe   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Cell type specification and diversity in subpallial organoids

Frontiers in Genetics
Neural organoids have emerged as valuable tools for studying the developing brain, sparking enthusiasm and driving their adoption in disease modeling, drug screening, and investigating fetal neural development.
Narciso Pavon, Narciso Pavon, Yubing Sun, ChangHui Pak   +3 more
doaj   +1 more source

Probing extracellular Sonic hedgehog in neurons

Biology Open, 2016
The bioactivity of Sonic hedgehog (Shh) depends on specific lipid modifications; a palmitate at its N-terminus and a cholesterol at its C-terminus. This dual-lipid modification makes Shh molecules lipophilic, which prevents them from diffusing freely in ...
Erez Eitan, Ronald S. Petralia, Ya-Xian Wang, Fred E. Indig, Mark P. Mattson, Pamela J. Yao   +5 more
doaj   +1 more source

Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]

, 2008
[eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Shh Overexpression Is Correlated with GRP78 and AR Expression in Primary Prostate Cancer: Clinicopathological Features and Outcomes in a Chinese Cohort

Cancer Management and Research, 2020
Xiangyu Zhang,1,* Yanmin Zhang,2,* Fanzhong Lin,1 Xin Shi,1 Longquan Xiang,1 Liang Li1 1Department of Pathology, Jining First People’s Hospital, Jining Medical University, Jining 272000, People’s Republic of China; 2Department of Pathology ...
Zhang X, Zhang Y, Lin F, Shi X, Xiang L, Li L   +5 more
doaj  

A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development

Frontiers in Cell and Developmental Biology, 2021
Enhancers that are conserved deep in evolutionary time regulate characteristics held in common across taxonomic classes. Here, deletion of the highly conserved Shh enhancer SBE2 (Shh brain enhancer 2) in mouse markedly reduced Shh expression within the ...
Zoe Crane-Smith, Jeffrey Schoenebeck, Katy A. Graham, Paul S. Devenney, Lorraine Rose, Mark Ditzell, Eve Anderson, Joseph I. Thomson, Natasha Klenin, Deborah M. Kurrasch, Laura A. Lettice, Robert E. Hill   +11 more
doaj   +1 more source

Signaling properties of lipoprotein-associated Shh and Shh-N* in Shh-LIGHT2 cells.

, 2013
(A, B) Concentration-dependent signaling activity of (A) lipoprotein-associated Shh and (B) Shh-N*. Lipoprotein concentration in (A) was kept constant, and only the fraction carrying Shh increased.
Monika Ehrhart-Bornstein (388277), Suzanne Eaton (148661), Wilhelm Palm (148641), Stefan R. Bornstein (114705), Marta M. Swierczynska (388275), Veena Kumari (388276)   +5 more
core   +1 more source