Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease [PDF]
Open Biology, 2021 Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins.
Marilyn D. Resh
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Hedgehog proteins create a dynamic cholesterol interface. [PDF]
PLoS ONE, 2021 During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation.
Amirhossein Mafi +10 more
doaj +6 more sources
Palmitoylation of Hedgehog proteins. [PDF]
Vitam Horm, 2012 Hedgehog (Hh) proteins are secreted signaling proteins that contain amide-linked palmitate at the N-terminus and cholesterol at the C-terminus. Palmitoylation of Hh proteins is critical for effective long- and short-range signaling. The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER.
Buglino JA, Resh MD.
europepmc +4 more sources
Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification [PDF]
JOR Spine, 2019 Parathyroid hormone‐related protein (PTHrP) and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is unknown.
Frances C. Bach +9 more
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Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infraorbital blood–nerve barrier following chronic constriction injury? [PDF]
Molecular Pain, 2017 Background Blood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Nathan Moreau +7 more
doaj +5 more sources
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling [PDF]
Nature Communications, 2021 AbstractHedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity ...
Samuel C. Griffiths +11 more
openaire +4 more sources
Frontiers in Dental Medicine, 2021 This study aimed to elucidate the role of the Sonic hedgehog (Shh)–Patched (Ptch)–Gli signaling pathway in maintaining dental epithelial and pulp stem/progenitor cells and regulating the function of odontoblasts.
Yuko Ishikawa +4 more
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Frontiers in Cell and Developmental Biology, 2023 Objective: The nucleus pulposus (NP) comprises notochordal NP cells (NCs) and chondrocyte-like NP cells (CLCs). Although morphological similarities between CLCs and chondrocytes have been reported, interactions between CLCs and NCs remain unclear.
Hiroki Hagizawa +7 more
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Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life. [PDF]
, 2018 Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic ...
Roelink, Henk
core +6 more sources
Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer
Life, 2022 The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and ...
Fan Yang +4 more
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