Results 1 to 10 of about 55,434 (254)

Method for Cellular Imaging of Palmitoylated Proteins with Clickable Probes and Proximity Ligation Applied to Hedgehog, Tubulin, and Ras

Journal of the American Chemical Society, 2014
Xinxin Gao, Rami N Hannoush
exaly  

Caenorhabditis elegans Hedgehog-related proteins are tissue- and substructure-specific components of the cuticle and precuticle

Genetics
Meera V Sundaram, Chelsea B Darwin, Nicholas D Serra   +2 more
exaly  

Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease [PDF]

Open Biology, 2021
Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins.
Marilyn D. Resh
doaj   +6 more sources

Hedgehog proteins create a dynamic cholesterol interface. [PDF]

PLoS ONE, 2021
During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation.
Amirhossein Mafi, Rahul Purohit, Erika Vielmas, Alexa R Lauinger, Brandon Lam, Yu-Shiuan Cheng, Tianyi Zhang, Yiran Huang, Soo-Kyung Kim, William A Goddard, Alison E Ondrus   +10 more
doaj   +6 more sources

Palmitoylation of Hedgehog Proteins [PDF]

Vitamins and Hormones, 2012
Hedgehog (Hh) proteins are secreted signaling proteins that contain amide-linked palmitate at the N-terminus and cholesterol at the C-terminus. Palmitoylation of Hh proteins is critical for effective long- and short-range signaling. The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER.
Marilyn D Resh
exaly   +5 more sources

Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification [PDF]

JOR Spine, 2019
Parathyroid hormone‐related protein (PTHrP) and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is unknown.
Frances C. Bach, Kim M. deRooij, Frank M. Riemers, Joseph W. Snuggs, Willem A. M. deJong, Ying Zhang, Laura B. Creemers, Danny Chan, Christine Le Maitre, Marianna A. Tryfonidou   +9 more
doaj   +2 more sources

Computational investigation of naturally occurring anticancer agents in regulating Hedgehog pathway proteins.

PLoS ONE
Embryonic development in humans is controlled by the Hedgehog pathway, which becomes inactive in mature tissues. Except for tissue maintenance and healing, activation of this pathway results in tumorigenesis with only a few exceptions.
Renu Pai, Divijendranatha Reddy Sirigiri, Rajyalakshmi Malempati, Saisha Vinjamuri   +3 more
doaj   +2 more sources

Identification of Proteins and Genes Associated with Hedgehog Signaling Pathway Involved in Neoplasm Formation Using Text-Mining Approach

Big Data Mining and Analytics
Analysis of molecular mechanisms that lead to the development of various types of tumors is essential for biology and medicine, because it may help to find new therapeutic opportunities for cancer treatment and cure including personalized treatment ...
Nadezhda Yu. Biziukova, Sergey M. Ivanov, Olga A. Tarasova   +2 more
doaj   +3 more sources

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling [PDF]

Nature Communications, 2021
AbstractHedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity ...
Griffiths, SC, Schwab, RA, El Omari, K, Bishop, B, Iverson, EJ, Malinauskas, T, Dubey, R, Qian, M, Covey, DF, Gilbert, RJC, Rohatgi, R, Siebold, C   +11 more
openaire   +4 more sources

The Sonic Hedgehog–Patched–Gli Signaling Pathway Maintains Dental Epithelial and Pulp Stem/Progenitor Cells and Regulates the Function of Odontoblasts

Frontiers in Dental Medicine, 2021
This study aimed to elucidate the role of the Sonic hedgehog (Shh)–Patched (Ptch)–Gli signaling pathway in maintaining dental epithelial and pulp stem/progenitor cells and regulating the function of odontoblasts.
Yuko Ishikawa, Hiroko Ida-Yonemochi, Kotaro Saito, Mitsushiro Nakatomi, Hayato Ohshima   +4 more
doaj   +1 more source