Results 1 to 10 of about 58,291 (117)
The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
Dose-Response, 2019 Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and ...
Chang Liu
exaly +2 more sources
Sonic hedgehog pathway expression in non-small cell lung cancer
Therapeutic Advances in Medical Oncology, 2012 Objective: Activation of the hedgehog pathway is an important signaling mechanism crucial in embryogenesis and has strong links to carcinogenesis. This study investigates the expression of the Sonic hedgehog pathway molecules in non-small cell lung ...
Malvi Savani +2 more
exaly +2 more sources
The Proteasome and Cul3-Dependent Protein Ubiquitination Is Required for Gli Protein-Mediated Activation of Gene Expression in the Hedgehog Pathway [PDF]
CellsMany cellular processes are regulated by proteasome-mediated protein degradation, including regulation of signaling pathways and gene expression. Among the pathways regulated by the ubiquitin–proteasome system is the Hedgehog pathway and its downstream ...
Tomasz Uśpieński, Paweł Niewiadomski
doaj +2 more sources
Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
doaj +1 more source
Hedgehog Signaling Modulates Glial Proteostasis and Lifespan
Cell Reports, 2020 Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis +6 more
doaj +1 more source
The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. [PDF]
PLoS Biology, 2005 Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates. Misregulation of the Hedgehog pathway causes developmental abnormalities and has been implicated in certain types of cancer.
Ian G Woods, William S Talbot
doaj +1 more source
Nature Communications, 2023 Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease –
Meropi Bagka +8 more
doaj +1 more source
Frontiers in Physiology, 2018 Hedgehog signaling pathway participates in a chain of necessary physiological activities and dysregulation of the hedgehog signaling has been implicated in birth defects and diseases.
Huijuan Li +4 more
doaj +1 more source
Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells. [PDF]
PLoS ONE, 2014 Differentiation therapy is a means to treat cancer and is induced by different agents with low toxicity and more specificity than traditional ones. Diosgenin, a plant steroid, is able to induce megakaryocytic differentiation or apoptosis in human HEL ...
Lamia Ghezali +4 more
doaj +1 more source
Cells, 2022 The Hedgehog signaling pathway regulates many processes during embryogenesis and the homeostasis of adult organs. Recent data suggest that central metabolic processes and signaling cascades in the liver are controlled by the Hedgehog pathway and that ...
Fritzi Ott +12 more
doaj +1 more source