Results 11 to 20 of about 58,440 (262)
The Role of the Hedgehog Pathway in Cholangiocarcinoma [PDF]
Cancers, 2021 Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and, along with hepatocellular carcinoma (HCC), is the predominant type of primitive liver cancer in adults. The lack of understanding of CCA biology has slowed down the identification of novel targets and the development of effective treatments.
Anichini G. +4 more
openaire +3 more sources
Targeting the Hedgehog Pathway in Rhabdomyosarcoma. [PDF]
Cancers (Basel), 2023 Aberrant activation of the Hedgehog (Hh) signalling pathway is known to play an oncogenic role in a wide range of cancers; in the particular case of rhabdomyosarcoma, this pathway has been demonstrated to be an important player for both oncogenesis and cancer progression.
Zarzosa P +11 more
europepmc +7 more sources
Crosstalk of Hedgehog and mTORC1 Pathways [PDF]
Cells, 2020 Hedgehog (Hh) signaling and mTOR signaling, essential for embryonic development and cellular metabolism, are both coordinated by the primary cilium. Observations from cancer cells strongly indicate crosstalk between Hh and mTOR signaling. This hypothesis is supported by several studies: Evidence points to a TGFβ-mediated crosstalk; Increased PI3K/AKT ...
Lasse Jonsgaard Larsen +1 more
openaire +3 more sources
Cell, 2016 The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).
Sekulic, Aleksandar, Von Hoff, Daniel
openaire +2 more sources
Activation of the hedgehog pathway in advanced prostate cancer
Molecular Cancer, 2004 Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore,
McCormick Frank +8 more
doaj +1 more source
Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer
Tumor Biology, 2017 The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers.
Dae-Hee Lee +2 more
doaj +1 more source
Hedgehog Signaling: An Achilles’ Heel in Cancer
Translational Oncology, 2019 Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth and patterning. It exerts its biological effect through a signaling mechanism that
Madiha Niyaz +2 more
doaj +1 more source
Hedgehog Signaling and Embryonic Craniofacial Disorders
Journal of Developmental Biology, 2019 Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog
John Abramyan
doaj +1 more source
The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
Communications Biology, 2021 By modulating the activation state of the Hedgehog pathway, de la Rocha-Muñoz et al demonstrate that Hedgehog signaling controls the expression and transport activity of the neuronal glycine transporter GlyT2.
Andrés de la Rocha-Muñoz +8 more
doaj +1 more source
The Hedgehog Signaling Pathway in Cancer [PDF]
Clinical Cancer Research, 2006 AbstractThe Hedgehog (Hh) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryogenesis, and aberrant reactivation of the pathway
Marie, Evangelista +2 more
openaire +3 more sources