Results 1 to 10 of about 29,268 (294)
Cilia-Associated Oxysterols Activate Smoothened [PDF]
Molecular Cell, 2018 Summary Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood.
David R Raleigh +2 more
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Cells, 2018 Hedgehog-GLI (HH) signaling was originally identified as a critical morphogenetic pathway in embryonic development. Since its discovery, a multitude of studies have reported that HH signaling also plays key roles in a variety of cancer types and in ...
Silvia Pietrobono +2 more
exaly +4 more sources
Mechanisms of Smoothened Regulation in Hedgehog Signaling
Cells, 2021 The seven-transmembrane protein, Smoothened (SMO), has shown to be critical for the hedgehog (HH) signal transduction on the cell membrane (and the cilium in vertebrates).
Jie Zhang, Zulong Liu, Jianhang Jia
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Identification of a potent antagonist of smoothened in hedgehog signaling
Cell & Bioscience, 2021 Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan +8 more
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Frontiers in Immunology, 2021 Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association have
Diana C. Yánez +7 more
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Journal of Orthopaedic Surgery and Research, 2021 Backgrounds Finite element analysis (FEA) is an important tool during the spinal biomechanical study. Irregular surfaces in FEA models directly reconstructed based on imaging data may increase the computational burden and decrease the computational ...
Jingchi Li +9 more
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Structural Basis of Smoothened Activation in Hedgehog Signaling
Cell, 2018 SUMMARY The seven-transmembrane-spanning protein Smoothened is the central transducer in Hedgehog signaling, a pathway fundamental in development and in cancer. Smoothened is activated by cholesterol binding to its extracellular cysteine-rich domain (CRD)
Sanduo Zheng +2 more
exaly +2 more sources
The Role of Smoothened in Cancer
International Journal of Molecular Sciences, 2020 Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways.
Kuo-Shyang Jeng +2 more
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Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
Cancers, 2016 The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma ...
Richard L Carpenter +2 more
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Data in Brief, 2020 Inactivation of smoothened protein (SMO) by the antagonists in SHH-driven cancer types is essential for inhibition of cancer progression. This article presents molecular dynamics (MD) trajectories of water solution of three protein-ligand complexes ...
Mohammad Tasyriq Che Omar
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