Cilia-Associated Oxysterols Activate Smoothened [PDF]
Molecular Cell, 2018 Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in cilia and activate the Hedgehog pathway.
David R Raleigh +2 more
exaly +8 more sources
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling [PDF]
, 2014 Oxysterols bind the seven-spanner transmembrane protein Smoothened and potently activate vertebrate Hedgehog signaling, a pathway essential in embryonic development, adult stem cell maintenance and cancer.
Jao, Cindy +4 more
core +1 more source
Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma [PDF]
, 2012 Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40% of all cancers in the United States with a growing incidence rate in the last decades in all developed countries.
CUCCHI, DANILO +3 more
core +3 more sources
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. [PDF]
, 2013 Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway.
Bao, Ju +8 more
core +1 more source
Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. [PDF]
, 2019 Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB).
Abagyan, Ruben +7 more
core +1 more source
Grking the Smoothened signal [PDF]
Science Signaling, 2018 The essential Hedgehog signaling component GRK2 functions at the level of and downstream of Smoothened in both flies and vertebrates (Li et al . and Pusapati et al ., in 6 February 2018 issue).
Hayley J. Sharpe, Frederic J. de Sauvage
openaire +2 more sources
Targeting GLI factors to inhibit the Hedgehog pathway [PDF]
, 2015 Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina +4 more
core +2 more sources
Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]
, 2017 The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia +7 more
core +1 more source
Fog computing and convolutional neural network enabled prognosis for machining process optimization [PDF]
, 2019 Cloud enabled prognosis systems have been increasingly adopted by manufacturing industries. The effectiveness of the cloud systems is, however, crippled by the high latency of data transfer between shop floors and the cloud.To overcome the limitation ...
Li, Weidong +3 more
core +1 more source
Smoothened Complete Electrode Model [PDF]
SIAM Journal on Applied Mathematics, 2017 This work reformulates the complete electrode model of electrical impedance tomography in order to enable more efficient numerical solution. The model traditionally assumes constant contact conductances on all electrodes, which leads to a discontinuous Robin boundary condition since the gaps between the electrodes can be described by vanishing ...
Mustonen, Lauri, Hyvönen, Nuutti
openaire +5 more sources