Results 1 to 10 of about 22,572 (280)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

Cells, 2018
Hedgehog-GLI (HH) signaling was originally identified as a critical morphogenetic pathway in embryonic development. Since its discovery, a multitude of studies have reported that HH signaling also plays key roles in a variety of cancer types and in ...
Silvia Pietrobono, Barbara Stecca
exaly   +3 more sources

Mechanisms of Smoothened Regulation in Hedgehog Signaling

Cells, 2021
The seven-transmembrane protein, Smoothened (SMO), has shown to be critical for the hedgehog (HH) signal transduction on the cell membrane (and the cilium in vertebrates).
Zulong Liu, Jianhang Jia
exaly   +3 more sources

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

eLife, 2021
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +10 more
doaj   +1 more source

Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation

Open Biology, 2021
Smoothened is a key receptor of the hedgehog pathway, but the roles of Smoothened in cardiac development remain incompletely understood. In this study, we found that the conditional knockout of Smoothened from the mesoderm impaired the development of the
Chaohui Zhang, Yuxin Li, Jiaheng Cao, Beibei Yu, Kaiyue Zhang, Ke Li, Xinhui Xu, Zhikun Guo, Yinming Liang, Xiao Yang, Zhongzhou Yang, Yunfu Sun, Vesa Kaartinen, Keyue Ding, Jikui Wang   +14 more
doaj   +1 more source

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

eLife, 2022
The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.
Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam   +5 more
doaj   +1 more source

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

Cells, 2023
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling.
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian   +8 more
doaj   +1 more source

Identification of a potent antagonist of smoothened in hedgehog signaling

Cell & Bioscience, 2021
Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan, Haowen Li, Lun Kuang, Zichen Zhao, Wenyan He, Chen Liu, Yongjun Wang, Steven Y. Cheng, Wei Chen   +8 more
doaj   +1 more source

Sonic Hedgehog Signaling in Cerebellar Development and Cancer

Frontiers in Cell and Developmental Biology, 2022
The sonic hedgehog (SHH) pathway regulates the development of the central nervous system in vertebrates. Aberrant regulation of SHH signaling pathways often causes neurodevelopmental diseases and brain tumors.
Wanchen Wang, Ryo Shiraishi, Ryo Shiraishi, Daisuke Kawauchi   +3 more
doaj   +1 more source

Case Report: Prenatal Diagnosis of Postaxial Polydactyly With Bi-Allelic Variants in Smoothened (SMO)

Frontiers in Genetics, 2022
Postaxial polydactyly is a common congenital malformation which involves complex genetic factors. This retrospective study analyzed the cytogenetic and molecular results of a Chinese fetus diagnosed with postaxial polydactyly of all four limbs.
Lihong Fan, Pengzhen Jin, Yeqing Qian, Guosong Shen, Xueping Shen, Minyue Dong, Minyue Dong   +6 more
doaj   +1 more source

Connexin 43 and Sonic Hedgehog Pathway Interplay in Glioblastoma Cell Proliferation and Migration

Biology, 2021
Glioblastoma (GBM) represents the most common primary brain tumor within the adult population. Current therapeutic options are still limited by high rate of recurrences and signalling axes that promote GBM aggressiveness.
Filippo Torrisi, Cristiana Alberghina, Debora Lo Furno, Agata Zappalà, Samuel Valable, Giovanni Li Volti, Daniele Tibullo, Nunzio Vicario, Rosalba Parenti   +8 more
doaj   +1 more source