Results 21 to 30 of about 29,268 (294)

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

Science Advances, 2022
Smoothened (SMO) transduces the Hedgehog (Hh) signal across the plasma membrane in response to accessible cholesterol. Cholesterol binds SMO at two sites: one in the extracellular cysteine-rich domain (CRD) and a second in the transmembrane domain (TMD).
M. Kinnebrew, R. E. Woolley, T. Ansell, E. Byrne, Sara Frigui, G. Luchetti, R. Sircar, S. Nachtergaele, Laurel Mydock-McGrane, K. Krishnan, S. Newstead, M. Sansom, D. Covey, C. Siebold, R. Rohatgi   +14 more
semanticscholar   +1 more source

Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation

Open Biology, 2021
Smoothened is a key receptor of the hedgehog pathway, but the roles of Smoothened in cardiac development remain incompletely understood. In this study, we found that the conditional knockout of Smoothened from the mesoderm impaired the development of the
Chaohui Zhang, Yuxin Li, Jiaheng Cao, Beibei Yu, Kaiyue Zhang, Ke Li, Xinhui Xu, Zhikun Guo, Yinming Liang, Xiao Yang, Zhongzhou Yang, Yunfu Sun, Vesa Kaartinen, Keyue Ding, Jikui Wang   +14 more
doaj   +1 more source

A PKA Inhibitor Motif within SMOOTHENED Controls Hedgehog Signal Transduction

bioRxiv, 2021
The Hedgehog (Hh) cascade is central to development, tissue homeostasis, and cancer. A pivotal step in Hh signal transduction is the activation of GLI transcription factors by the atypical G protein-coupled receptor (GPCR) Smoothened (SMO).
John T. Happ, Corvin D. Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B. Nelson, C. Olivieri, Jingyi Zhang, Danielle S. Hedeen, Ju-Fen Zhu, Jacob L. Capener, Jan W. Bröckel, Lily Vu, C. King, V. Ruiz-Perez, Xuecai Ge, G. Veglia, F. Herberg, Susan S. Taylor, Benjamin R. Myers   +18 more
semanticscholar   +1 more source

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

eLife, 2022
The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.
Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam   +5 more
doaj   +1 more source

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

Cells, 2023
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling.
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian   +8 more
doaj   +1 more source

Sonic Hedgehog Signaling in Cerebellar Development and Cancer

Frontiers in Cell and Developmental Biology, 2022
The sonic hedgehog (SHH) pathway regulates the development of the central nervous system in vertebrates. Aberrant regulation of SHH signaling pathways often causes neurodevelopmental diseases and brain tumors.
Wanchen Wang, Ryo Shiraishi, Ryo Shiraishi, Daisuke Kawauchi   +3 more
doaj   +1 more source

Case Report: Prenatal Diagnosis of Postaxial Polydactyly With Bi-Allelic Variants in Smoothened (SMO)

Frontiers in Genetics, 2022
Postaxial polydactyly is a common congenital malformation which involves complex genetic factors. This retrospective study analyzed the cytogenetic and molecular results of a Chinese fetus diagnosed with postaxial polydactyly of all four limbs.
Lihong Fan, Pengzhen Jin, Yeqing Qian, Guosong Shen, Xueping Shen, Minyue Dong, Minyue Dong   +6 more
doaj   +1 more source

Connexin 43 and Sonic Hedgehog Pathway Interplay in Glioblastoma Cell Proliferation and Migration

Biology, 2021
Glioblastoma (GBM) represents the most common primary brain tumor within the adult population. Current therapeutic options are still limited by high rate of recurrences and signalling axes that promote GBM aggressiveness.
Filippo Torrisi, Cristiana Alberghina, Debora Lo Furno, Agata Zappalà, Samuel Valable, Giovanni Li Volti, Daniele Tibullo, Nunzio Vicario, Rosalba Parenti   +8 more
doaj   +1 more source

Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors

Acta Pharmaceutica, 2022
Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). The significant shift toward the use of these novel therapeutics, administered either alone or in
Fersing Cyril, Mathias Fanny
doaj   +1 more source

Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling

Frontiers in Cell and Developmental Biology, 2022
The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling.
Jianhang Jia, Jin Jiang
doaj   +1 more source