Results 21 to 30 of about 22,572 (280)
Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle
Current Issues in Molecular Biology, 2022 Liver regeneration is a complicated biological process orchestrated by various liver resident cells. Hepatic cell proliferation and reconstruction of the hepatic architecture involve multiple signaling pathways. It has been reported that the Hh signal is
Jiawang Tao +7 more
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Smoothened Complete Electrode Model [PDF]
SIAM Journal on Applied Mathematics, 2017 This work reformulates the complete electrode model of electrical impedance tomography in order to enable more efficient numerical solution. The model traditionally assumes constant contact conductances on all electrodes, which leads to a discontinuous Robin boundary condition since the gaps between the electrodes can be described by vanishing ...
Mustonen, Lauri, Hyvönen, Nuutti
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Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
Case Reports in Dermatology, 2021 In basal cell carcinoma (BCC) tumorigenesis, interaction between Hedgehog (Hh) and Wnt/β-catenin (Wnt) signaling pathways has been investigated, but not completely elucidated.
Tomoaki Takada
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Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
eLife, 2013 The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich domain (
Sigrid Nachtergaele +9 more
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eLife, 2020 Dynamic trafficking of G protein-coupled receptors (GPCRs) out of cilia is mediated by the BBSome. In concert with its membrane recruitment factor, the small GTPase ARL6/BBS3, the BBSome ferries GPCRs across the transition zone, a diffusion barrier at ...
Shuang Yang +6 more
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Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling
, 2019 Hedgehog proteins are pivotal morphogens acting through a canonical pathway involving first activation of ligand binding to Patched followed by alleviation of Smoothened receptor inhibition, leading to activation of Gli transcription factors ...
Spek, C.A. (C. Arnold) +29 more
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Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling [PDF]
, 2014 Oxysterols bind the seven-spanner transmembrane protein Smoothened and potently activate vertebrate Hedgehog signaling, a pathway essential in embryonic development, adult stem cell maintenance and cancer.
Liu, Jing +4 more
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Grking the Smoothened signal. [PDF]
, 2019 The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal transducer Smoothened. Two
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Signal transduction of the GPCR Smoothened: a key protein in Hedgehog-regulated morphogenesis and oncogenesis [PDF]
, 2022 The Hedgehog signalling pathway is crucial for embryonic development and tissue homeostasis. Misregulation can result in severe developmental defects or oncogenesis, with an estimated 25% of all cancer deaths exhibiting improper Hedgehog signalling.
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MGM Journal of Medical Sciences, 2020 Introduction: In recent years, increased cancer incidences and death rates due to it, have turned cancer to be a major problem worldwide. Approximately more than 7 million people globally die from cancer.
Sanika Dhorje +2 more
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