Results 21 to 30 of about 41,949 (243)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Secret Life of Smoothened [PDF]
Developmental Cell, 2003 AbstractThe membrane protein Smoothened is the signal-generating component of the Hedgehog pathway. How Smoothened transmits the signal to downstream effectors in the cytoplasm has been a long-standing mystery. Now, with recent reports demonstrating a direct interaction between Smoothened and Costal-2, we appear to be significantly closer to solving ...
Collins, Russell T, Cohen, Stephen M
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Structure and functional motifs of GCR1, the only plant protein with a GPCR fold? [PDF]
, 2013 Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G protein coupled receptors (GPCRs), arises because of their importance in signaling.
Abdalla, Nuradin Y +6 more
core +1 more source
The Role of Smoothened in Cancer [PDF]
International Journal of Molecular Sciences, 2020 Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway ...
Kuo-Shyang Jeng +4 more
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K [PDF]
, 2018 SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric Gi proteins in many cell types, including cardiomyocytes.
Al-Owais, Moza +6 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Sharp inflaton potentials and bi-spectra: Effects of smoothening the discontinuity
, 2014 Sharp shapes in the inflaton potentials often lead to short departures from slow roll which, in turn, result in deviations from scale invariance in the scalar power spectrum.
Hazra, Dhiraj Kumar +2 more
core +2 more sources
Estimation, Analysis and Smoothing of Self-Similar Network Induced Delays in Feedback Control of Nuclear Reactors [PDF]
, 2012 This paper analyzes a nuclear reactor power signal that suffers from network induced random delays in the shared data network while being fed-back to the Reactor Regulating System (RRS).
Das, Saptarshi +5 more
core +2 more sources