Results 41 to 50 of about 29,268 (294)
eLife, 2020 Dynamic trafficking of G protein-coupled receptors (GPCRs) out of cilia is mediated by the BBSome. In concert with its membrane recruitment factor, the small GTPase ARL6/BBS3, the BBSome ferries GPCRs across the transition zone, a diffusion barrier at ...
Shuang Yang +6 more
doaj +1 more source
E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened
Journal of Cell Biology, 2021 At the basal state, the ciliary levels of Smo are kept low through the actions of a ciliary localized E2 ubiquitin–conjugating enzyme, Ube2l3, and an E3 ubiquitin ligase, Wwp1.
Bo Lv +4 more
semanticscholar +1 more source
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
Genes & Development, 2002 The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling.
James K. Chen +3 more
semanticscholar +1 more source
Smoothened agonist sterosome immobilized hybrid scaffold for bone regeneration
Science Advances, 2020 Hybrid scaffold with smoothened agonist sterosomes is engineered as a useful bone graft device for more efficacious bone healing. Biomaterial delivery of bioactive agents and manipulation of stem cell fate are an attractive approach to promote tissue ...
Chung‐Sung Lee +5 more
semanticscholar +1 more source
MGM Journal of Medical Sciences, 2020 Introduction: In recent years, increased cancer incidences and death rates due to it, have turned cancer to be a major problem worldwide. Approximately more than 7 million people globally die from cancer.
Sanika Dhorje +2 more
doaj +1 more source
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. [PDF]
, 2006 Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation and differentiation through activation ...
Meloni, AR +7 more
core +1 more source
, 2003 The membrane protein Smoothened is the signal-generating component of the Hedgehog pathway. How Smoothened transmits the signal to downstream effectors in the cytoplasm has been a long-standing mystery.
Cohen, Stephen M, Collins, Russell T
core +1 more source
eLife, 2016 Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and is increasing in prevalence. The pathomechanisms, however, are poorly understood.
Madlen Matz-Soja +13 more
doaj +1 more source
Developmental Cell, 2020 The mechanisms underlying subcellular targeting of cAMP-generating adenylyl cyclases and processes regulated by their compartmentalization are poorly understood.
B. Somatilaka +6 more
semanticscholar +1 more source
Distribution of Smoothened at hippocampal mossy fiber synapses.
, 2007 The seven-transmembrane receptor Smoothened is essential for hedgehog signal transduction. In adulthood, the highest density of Smoothened mRNA is found in the granule cell layer of the dentate gyrus.
Masdeu, Christelle +4 more
core +1 more source