Results 41 to 50 of about 22,572 (280)
Developmental and Repairing Production of Myelin: The Role of Hedgehog Signaling
Frontiers in Cellular Neuroscience, 2018 Since the discovery of its role as a morphogen directing ventral patterning of the spinal cord, the secreted protein Sonic Hedgehog (Shh) has been implicated in a wide array of events contributing to the development, maintenance and repair of the central
Yousra Laouarem, Elisabeth Traiffort
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Patched-mediated regulation of Smoothened trafficking and activity by Lipophorin-derived lipids [PDF]
, 2010 Hedgehog is a lipid-linked morphogen that is carried on lipoprotein particles and that regulates both patterning and proliferation in a wide variety of vertebrate and invertebrate tissues.
Khaliullina-Skultety, Helena
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Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway
Cancer ReportsHepatocellular carcinoma (HCC) is the sixth most common malignant tumors and the third leading cause of cancer‐related death worldwide. As an oncogene, Rab23 has been shown to be significantly related to the growth and migration of hepatocellular ...
Si‐Jia Liu +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling
, 2011 It takes two kinases and two phosphatases acting on a single membrane protein Smoothened to interpret the Hedgehog morphogen gradient.
Junzheng Zhang +5 more
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, 2020 Vlk is a secreted tyrosine kinase that plays crucial roles during vertebrate embryonic development including skeletal formation. Genetic studies suggest that Vlk can modulate the Hedgehog signaling pathway during skeletal development.
여창열
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling
Scientific Reports, 2017 The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway.
Jieun Kim +8 more
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ZNF423 knockdown quantitatively alters Smoothened translocation.
, 2016 (A) RT-PCR shows Zfp423 expression in mouse P19 cells [32] and ZNF423 RNA expression in DAOY medulloblastoma cells. GAPDH was used as a positive control. M, size marker.
Chen-Jei Hong (418943) +1 more
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