Results 61 to 70 of about 22,572 (280)
The hedgehog receptor patched is involved in cholesterol transport. [PDF]
PLoS ONE, 2011 Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors,
Michel Bidet +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Automatic segmentation of Phonocardiogram using the occurrence of the cardiac events
Informatics in Medicine Unlocked, 2017 Objective: This paper presents automatic method of segmentation of heart sound using the occurrence of the cardiac rhythmic events. Methods: Noisy heart sound is filtered using the 6th order Chebyshev type I low pass filter to remove the redundant noise.
M. Vishwanath Shervegar, Ganesh V. Bhat
doaj +1 more source
Related Articles from Targeting the Hedgehog Pathway in Cancer: Can the Spines Be Smoothened?
, 2011 Related Articles from Targeting the Hedgehog Pathway in Cancer: Can the Spines Be ...
Laurie Ailles (3431195) +1 more
core +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development [PDF]
, 2013 Background Several studies have indicated that Sonic hedgehog (Shh) regulates the expansion of dopaminergic (DA) progenitors and the subsequent generation of mature DA neurons.
Luo, Sarah +13 more
core +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Friction, 2018 Silicon carbide (SiC) can be tribo-chemically smoothened during a self-mated sliding procedure in the aqueous environment. As well reported in the point-contact tests, this smoothening process works well due to the abundant water as oxidant.
Le Jin +4 more
doaj +1 more source