Results 61 to 70 of about 29,268 (294)
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
eLife, 2013 Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.
Yu Wang, Andrew P McMahon
doaj +1 more source
Structural basis for Smoothened regulation by its extracellular domains
Nature, 2016 Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the membrane by Frizzled-class G-protein-coupled receptors (GPCRs) composed of both a heptahelical transmembrane domain (TMD) and an extracellular cysteine-rich domain (CRD)
E.X.B. Byrne +13 more
semanticscholar +1 more source
, 2018 The essential Hedgehog signaling component GRK2 functions at the level of and downstream of Smoothened in both flies and vertebrates (Li et al . and Pusapati et al ., in 6 February 2018 issue).
Frederic J. de Sauvage, Hayley J. Sharpe
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling
Scientific Reports, 2017 The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway.
Jieun Kim +8 more
doaj +1 more source
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
eLife, 2019 Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016).
Maia Kinnebrew +12 more
doaj +1 more source
Cellular cholesterol directly activates Smoothened in Hedgehog signaling
Cell, 2016 Summary In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding its extracellular, cysteine-rich domain (CRD).
Pengxiang Huang* +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling
bioRxiv, 2019 In the absence of hedgehog ligand, patched-1 (Ptch1) localizes to cilia and prevents ciliary accumulation and activation of smoothened (Smo). Upon ligand binding, Ptch1 is removed from cilia, Smo is derepressed and accumulates in cilia where it activates
Paurav B. Desai +3 more
semanticscholar +1 more source